DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and PIK3CA

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_006209.2	Gene:	PIK3CA / 5290	HGNCID:	8975	Length:	1068	Species:	Homo sapiens

Alignment Length:	649	Identity:	122/649 - (18%)
Similarity:	204/649 - (31%)	Gaps:	231/649 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1743 CLLWDEYWIHSLAHI---------YNTYVSRVSALATDFRPDDHEGKNNRF---NVWRPQLLADL 1795
            ||..:..|..|:...         .|..|||.:..:.     .|.|.:||.   |..|..   |.
Human   472 CLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSY-----SHAGLSNRLARDNELREN---DK 528

  Fly  1796 EALVAVTSRPP---ETTYERSFRKRFDAPIRLTVDALRHRRY----PE---------AW---DKL 1841
            |.|.|:::|.|   .|..|:.|             ...||.|    ||         .|   |::
Human   529 EQLKAISTRDPLSEITEQEKDF-------------LWSHRHYCVTIPEILPKLLLSVKWNSRDEV 580

  Fly  1842 KQLYHILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDG----------------- 1889
            .|:|.:::.           ...|.|        ..:|..||.:.||.
Human   581 AQMYCLVKD-----------WPPIKP--------EQAMELLDCNYPDPMVRGFAVRCLEKYLTDD 626

  Fly  1890 --DQVYIESV-----ESSVCVLPTKTKPKKVAFYGSNGQR--YTFLFKGMEDLHLDERIMQF-LS 1944
              .|..|:.|     |..:..|..:...||..    ..||  :.|.:....::|......:| |.
Human   627 KLSQYLIQLVQVLKYEQYLDNLLVRFLLKKAL----TNQRIGHFFFWHLKSEMHNKTVSQRFGLL 687

  Fly  1945 ISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAG 2009
            :.:...||       |.|..|      |..|...:..:..:|.:....||.:.::.|:.
Human   688 LESYCRAC-------GMYLKH------LNRQVEAMEKLINLTDILKQEKKDETQKVQMK------ 733

  Fly  2010 AVANVPRR--FTDLFYNKLSPLLAKH---NMQVSDPR----------RQWP----ISVLLQVLDE 2055
            .:....||  |.|.....||||...|   |:::.:.|          ..|.    :|.||...:|
Human   734 FLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNE 798

  Fly  2056 LSQETPNDL-----------LARELW-------------------------------------CQ 2072
            :..:..:||           :...:|                                     |:
Human   799 IIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK 863

  Fly  2073 AG-------------------NAAE-WRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSG 2117
            .|                   |..| :..::..|.|..:...:..:::|:||||..|:::. ..|
Human   864 GGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVK-DDG 927

  Fly  2118 DIVHIDYN--VCFEKGRTLRIPEKVPFRLTQNLV-------QAMGITGIEGPFRLGCEYVLKVMR 2173
            .:.|||:.  :..:|.:.....|:|||.|||:.:       |....|.....|:..|......:|
Human   928 QLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIR 992

  Fly  2174 KERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNA-KLQESADGGGAGGLGVGDLKYHKKDKN 2236
            :.....:.|....:...:.:..:.||...:|::|.. |.::.|            |:|..|..|
Human   993 QHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEA------------LEYFMKQMN 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	31/132 (23%)
		PIKKc_SMG1	1894..2196	CDD:270714	72/405 (18%)
		FATC	3189..3217	CDD:280430
PIK3CA	NP_006209.2	PI3K_p85B	32..107	CDD:396665
		PI3K_rbd	173..292	CDD:197540
		C2_PI3K_class_I_alpha	325..484	CDD:176043	4/11 (36%)
		PI3Ka_I	525..696	CDD:238444	40/216 (19%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	69/382 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900