Protein Alignment nonC and PIK3C3

DIOPT Version :9

• Sequence 1: NP_001284967.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_002638.2
• Gene: PIK3C3 / 5289
• HGNCID: 8974
• Length: 887
• Species: Homo sapiens
• Alignment Length: 849
• Identity: 154/849 - (18%)
• Similarity: 269/849 - (31%)
• Gaps: 352/849 - (41%)

  Fly  1426 DSSQPL-------AIPQAERMVARLVHSCLQQ--------------RPNYA-----EALIAYGN- 1463
            |.|.|:       .:|..:..:..||.|...:              :||.|     ..:::|..
Human   241 DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPT 305

  Fly  1464 -----------WCYRWGKKVADSCCVLTQADATAISQAL-----DIPQ-------------PLES 1499
                       |.:|:         .||..: .|:::.|     |:||             |::.
Human   306 KQLTYEEQDLVWKFRY---------YLTNQE-KALTKFLKCVNWDLPQEAKQALELLGKWKPMDV 360

  Fly  1500 EKLDELLQALSTEQPPANCVEVCPDAARAR--DDEAAKNRLRRLTFLADKTPEALDAILQIWRRA 1562
            |...|||.:..| .|......|    ||.|  |||                    |.::.:.:..
Human   361 EDSLELLSSHYT-NPTVRRYAV----ARLRQADDE--------------------DLLMYLLQLV 400

  Fly  1563 IANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQR------ERLHVDDSNLVTTTLRLLRL 1621
            .|..|:.:.|          .|:|..|.|.:.:..||:.      ....:|.|.::|:.|..:.
Human   401 QALKYENFDD----------IKNGLEPTKKDSQSSVSENVSNSGINSAEIDSSQIITSPLPSVS- 454

  Fly  1622 IVKHASGLQEV-----LEQGLHTTPIAP------------WKVIIPQLFSRLNHHEPYVRKSVCD 1669
            ....||..:||     |||.|.|..|:.            |.||:.                 |:
Human   455 SPPPASKTKEVPDGENLEQDLCTFLISRACKNSTLANYLYWYVIVE-----------------CE 502

  Fly  1670 LLCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKL 1734
                               ..:.:|:|         |.|.:  .|..::...|:...:..:.|::
Human   503 -------------------DQDTQQRD---------PKTHE--MYLNVMRRFSQALLKGDKSVRV 537

  Fly  1735 MVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADLEAL- 1798
            |     |..|...:.::..|.|:... |.|.|.        :.:.||.|...    ||.|.|.:
Human   538 M-----RSLLAAQQTFVDRLVHLMKA-VQRESG--------NRKKKNERLQA----LLGDNEKMN 584

  Fly  1799 ---VAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRGSGSTL 1860
               |.:...|.|                           |:                       :
Human   585 LSDVELIPLPLE---------------------------PQ-----------------------V 599

  Fly  1861 KMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTF 1925
            |::.|.|                               .:..:..:...|.::.|...:|.:|..
Human   600 KIRGIIP-------------------------------ETATLFKSALMPAQLFFKTEDGGKYPV 633

  Fly  1926 LFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFA 1990
            :||..:||..|:.|:|.:|:.:.::  |.:   |...:...|.|:....:.|.:.::..| ||
Human   634 IFKHGDDLRQDQLILQIISLMDKLL--RKE---NLDLKLTPYKVLATSTKHGFMQFIQSV-PV-- 690

  Fly  1991 LYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDE 2055
                     ::|...  .|::.|        |:.|.:|
Human   691 ---------AEVLDT--EGSIQN--------FFRKYAP--------------------------- 709

  Fly  2056 LSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIV 2120
             |:..||.:.|              :.:..:|:..:...:|.|::|:|||||||:|:. .:|.:.
Human   710 -SENGPNGISA--------------EVMDTYVKSCAGYCVITYILGVGDRHLDNLLLT-KTGKLF 758

  Fly  2121 HIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIE--GPFRLGCEYVLKVMRKERETLLTLL 2183
            |||:.  :..||..: |...|.:|.:.:|:.||.|..|  ..||..|......:|:....:|.|.
Human   759 HIDFG--YILGRDPK-PLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLF 820

  Fly  2184 EAFV 2187
            ...|
Human   821 SLMV 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	18/110 (16%)
		PIKKc_SMG1	1894..2196	CDD:270714	63/296 (21%)
		FATC	3189..3217	CDD:280430
PIK3C3	NP_002638.2	C2_PI3K_class_III	26..186	CDD:176042
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..170
		PI3Ka_III	283..503	CDD:238442	55/301 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..467		6/20 (30%)
		PI3Kc_III	539..883	CDD:270628	84/453 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900