DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and PIK3C2B

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_001364263.1	Gene:	PIK3C2B / 5287	HGNCID:	8972	Length:	1634	Species:	Homo sapiens

Alignment Length:	1597	Identity:	312/1597 - (19%)
Similarity:	525/1597 - (32%)	Gaps:	535/1597 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1135 SEESCSSMDALG---GVFQQLSLWP-----SNWDE--------SVSSSGLSERASFSSIHM-RQR 1182
            |:...||....|   |..::||..|     |.||.        |.|||.:|:.:..::..: .|.
Human   134 SDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQL 198

  Fly  1183 TEDIVLHKLLEDRCV---PDQAKNLLDTQW---RDSLLNPSFDQRSCKELTLLRHIVQGVSGGQ- 1240
            ...::.|::||:..|   ..|.:.|....:   .|::..  .:.:|..:..:||...:|...|:
Human   199 PGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITR--LNLKSTYDAEMLRDATRGWKEGRG 261

  Fly  1241 ELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAET 1305
            .|.....:||:...|||.:...:..|..|.....|::..||  :...:.||........:.....
Human   262 PLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNATPG--KNRRISAAPVGSRPHTVANGHE 324

  Fly  1306 LLTQFFGQPIGEIAA----LFSLEQG--VQ------------TDNPEMLRGYSEL---VKCLHLQ 1349
            |. :...:...|:||    |..|..|  :|            |.:||.|.....|   |.|..|
Human   325 LF-EVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRL- 387

  Fly  1350 QQQSQTHSGDLSSSID--VCAALCL------NIQKSN-------------NQPAAGA-------- 1385
             |::.|.:.:.||::|  :...||.      |:...:             |:.|.|:
Human   388 -QEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALGSHEYIQYCR 451

  Fly  1386 ----DLLLNLADWIAVRTCNGLTTN--QSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARLV 1444
                |:.|.|.:...||:....|.|  |||..:..|..|.|.|:....|:     ||..::....
Human   452 KFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISR-----QALSLLFDTY 511

  Fly  1445 HSCLQQRPNYAEA-LIAYGNWCYRWGKKVADS----CCVLTQADATAISQALDIPQPLES----- 1499
            |       |..:| |:|.|::..: ..:|..|    |..|...:...|:.||:...|..|
Human   512 H-------NEVDAFLLADGDFPLK-ADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRMQPK 568

  Fly  1500 --------------EKLDELLQALSTEQPPANC------VEVCPDAARARD-DEAAKNRLRRLTF 1543
                          ||:.|.|.|...:.....|      .:.....:|..| .:.|.:..|.|.|
Human   569 IQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARSLAF 633

  Fly  1544 LADKTPEALDAILQIWRRAIANTY-DYYKDAA---------------RSYF-----------QYL 1581
                |..|...|..||    |.:| |:|...:               |::|           |.:
Human   634 ----TVYATHRIPIIW----ATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQI 690

  Fly  1582 SFKSGSG---------------PEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIV---KHASG 1628
            .|.....               |..|.|....:.::|...:....|||.|...|.::   :...|
Human   691 CFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLG 755

  Fly  1629 LQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDLLCRLAKSRPQLVIFPAVVGANRE 1693
            |....::    .|.|.|        |..|.|:                  |..||.......:..
Human   756 LWPATQE----NPSARW--------SAPNFHQ------------------PDSVILQIDFPTSAF 790

  Fly  1694 QQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKE---------LRRVCLLWDE- 1748
            ....|:||.       |.....|..|.|.::....::.:  |.||         .:|   ||::
Human   791 DIKFTSPPG-------DKFSPRYEFGSLREEDQRKLKDI--MQKESLYWLTDADKKR---LWEKR 843

  Fly  1749 YWIHS-------------------LAHIYN-----TYVSRVSAL----ATDFRPDDHEGKNNRFN 1785
            |:.||                   |..||.     |:::...||    ||  .||.   :..|..
Human   844 YYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHAT--FPDQ---EVRRMA 903

  Fly  1786 VWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAP-----IRLTVDALRHRRYPEAWDKLKQLY 1845
            |.....|:|.|.|..:    |:......:....|:|     ::..|..||...|          :
Human   904 VQWIGSLSDAELLDYL----PQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHY----------F 954

  Fly  1846 HILQSNMIRGSGSTLKMQSISPVL---CGIG--------------------RMRISMP----GLD 1883
            ..|..:.::.|..:::.|.:...|   ||.|                    ::|.:.|    |:.
Human   955 FWLLKDGLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGIL 1019

  Fly  1884 AHGPDGDQVYIESVE-----SSVCVLPTKTK-------PKKVAFYGSN--------------GQR 1922
            ..|       :|.|:     :..|.||....       |:..:::.||              |:.
Human  1020 RTG-------LEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGEN 1077

  Fly  1923 YTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWV-DGVT 1986
            ...:||..:||..|...:|.:.|.:.|                               || :|:.
Human  1078 IRVIFKCGDDLRQDMLTLQMIRIMSKI-------------------------------WVQEGLD 1111

  Fly  1987 PVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQ 2051
            ....:::.:...|       |.|.|..:|...|      |..:..:|.:..|...|  |::
Human  1112 MRMVIFRCFSTGR-------GRGMVEMIPNAET------LRKIQVEHGVTGSFKDR--PLA---- 1157

  Fly  2052 VLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGS 2116
              |.|.:..|.:             .|:.::|..|:...:...:..||:|:.|||.||:::.. :
Human  1158 --DWLQKHNPGE-------------DEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKT-T 1206

  Fly  2117 GDIVHIDYNVCFEKGRTLRIP--------EKVPFRLTQNLVQAMGITGIEGP------FRLGCEY 2167
            |.:.|||:      ||.|...        ::.||..|.::  |..|.|.:.|      |...|..
Human  1207 GHMFHIDF------GRFLGHAQMFGNIKRDRAPFVFTSDM--AYVINGGDKPSSRFHDFVDLCCQ 1263

  Fly  2168 VLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQESADGGGAGGLGVGDLKYHK 2232
            ...::||.....|.||...                    |:..:.|.:|        :.||||
Human  1264 AYNLIRKHTHLFLNLLGLM--------------------LSCGIPELSD--------LEDLKY-- 1298

  Fly  2233 KDKNKGKPLDSDVKRQPFLSKLGMLQKYWSTNKTELMPQLEEMEQEVGNLQAAQAKQVVAEEELV 2297
             ..:..:|.|::.....:.::|                    :|..:|::             ..
Human  1299 -VYDALRPQDTEANATTYFTRL--------------------IESSLGSV-------------AT 1329

  Fly  2298 KLNQRSALIAEIKSLGTAIESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQC 2362
            |||.....:|::|..|      |.:..:|..|.|           |..|...||:..:.....:
Human  1330 KLNFFIHNLAQMKFTG------SDDRLTLSFASR-----------THTLKSSGRISDVFLCRHE- 1376

  Fly  2363 LQLYHLLDLQGQLVKLQMESNSE------NAREFSALTEALQL----SGLDSMRSQLNELLGRM- 2416
             :::|.......:||:..|:..|      ...||..|...|:|    |.|.|..|:.  ::||.
Human  1377 -KIFHPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRF--VIGRSR 1438

  Fly  2417 -DMVAQKSSKHLQEYA-GVMNFYPEQSHRQNLFVRFH 2451
             :.||::..:.|..|. .:::..||.:....::..||
Human  1439 GEAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFH 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	1/4 (25%)
		Rapamycin_bind	1738..1845	CDD:285924	30/149 (20%)
		PIKKc_SMG1	1894..2196	CDD:270714	66/342 (19%)
		FATC	3189..3217	CDD:280430
PIK3C2B	NP_001364263.1	Interaction with GRB2. /evidence=ECO:0000269\|PubMed:11533253	2..298		38/165 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..188		16/53 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..315		14/57 (25%)
		PI3K_rbd	364..466	CDD:395642	22/103 (21%)
		C2A_PI3K_class_II	622..794	CDD:175979	37/209 (18%)
		PI3Ka_II	813..981	CDD:238441	36/191 (19%)
		PI3Kc_C2_beta	987..1340	CDD:119421	85/497 (17%)
		PX_PI3K_C2_beta	1369..1477	CDD:132823	24/111 (22%)
		C2B_PI3K_class_II	1505..1627	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900