DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonC and Pi3K92E

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	136/721 - (18%)
Similarity:	239/721 - (33%)	Gaps:	212/721 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1630 QEVLEQGLHTTPIAPW----KVIIPQLFSRLNHHEPYVRKSVC--------------------DL 1670
            :::|..|.||  :..|    .:...::|..|...||..||..|                    ::
  Fly   464 KDILRTGRHT--LYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEV 526

  Fly  1671 LCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYL--LGELSKQAPEAVQH-- 1731
            :.:.|..|.|:         ||.|:....|....:...|....|..|  :.|:..|...|:..
  Fly   527 VLQYAADREQV---------NRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERR 582

  Fly  1732 ---VKLMVKELRRV--CLLWDE------------YW--------IHSLAHIY-NTYVSRVSALAT 1770
               ::.:.:||..:  |:.|.|            .|        :..|.:.| :..|.|.:....
  Fly   583 NDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCL 647

  Fly  1771 DFRPDD--------------HEG---------------KNNR---FNVWRPQLLADLEALVAVTS 1803
            .|..|:              ||.               :|.|   :..|  .|.::::.
  Fly   648 HFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFW--HLRSEMQT------ 704

  Fly  1804 RPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHIL----QSNMIRGSGSTLKMQS 1864
                    .|.:.||...:.:.:...:|...|     |::..|:|    |.::|...||..|:::
  Fly   705 --------PSMQTRFGLLLEVYLKGCKHHVAP-----LRKQLHVLEKLKQGSLIAKKGSKEKVKT 756

  Fly  1865 ISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVC-VLPTKTKPKKVAFYGS--NGQRYTFL 1926
            :....  :...|.|....:...|.........|....| |:.:|.:|..|.|..:  |......:
  Fly   757 MLQDF--LRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHII 819

  Fly  1927 FKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFAL 1991
            ||..:||..|...:|.|.:.:.:.  :.|...   :|.:.|:.|.:....|:|..|
  Fly   820 FKNGDDLRQDMLTLQMLRVMDQLW--KRDGMD---FRMNIYNCISMEKSLGMIEVV--------- 870

  Fly  1992 YKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDEL 2056
                          ..|..:||:.:.              |.....:.|.::   ..||..|.|
  Fly   871 --------------RHAETIANIQKE--------------KGMFSATSPFKK---GSLLSWLKE- 903

  Fly  2057 SQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVH 2121
             ...|.|.|              .:::..|....:...:..||:|:.|||.||:::. .:|.:.|
  Fly   904 -HNKPADKL--------------NKAINEFTLSCAGYCVATYVLGVADRHSDNIMVK-RNGQLFH 952

  Fly  2122 IDYNVC---FEKGRTLRIPEKVPFRLTQNLVQAM--GITGIEGP----FRLGCEYVLKVMRKERE 2177
            ||:...   |::...:| .|:|||.||.:.|..:  |....|..    |:..||....|:||...
  Fly   953 IDFGHILGHFKEKLGVR-RERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGC 1016

  Fly  2178 TLLTLLEAFVYDPLVDWTTNDDAQALRRSL-------------NAKLQESADGGGAGGLGVGDLK 2229
            .:|:|....:...|.:.::..|...||.:|             .||..|:........|......
  Fly  1017 LILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHN 1081

  Fly  2230 YHKKDK 2235
            :.|.:|
  Fly  1082 FSKNNK 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	24/161 (15%)
		PIKKc_SMG1	1894..2196	CDD:270714	67/313 (21%)
		FATC	3189..3217	CDD:280430
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	12/54 (22%)
		PI3Ka_I	552..723	CDD:238444	27/186 (15%)
		PI3Kc_I	727..1084	CDD:270709	87/426 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900