DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and pik3cg

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_021330656.1	Gene:	pik3cg / 406598	ZFINID:	ZDB-GENE-040426-2532	Length:	1113	Species:	Danio rerio

Alignment Length:	1380	Identity:	263/1380 - (19%)
Similarity:	423/1380 - (30%)	Gaps:	494/1380 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1056 ALAGYRTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQR 1120
            |.||:.|::.|::...:..|..|:                   .|.|:::      |.:..|...
Zfish     7 ATAGFNTLVMEQQASDDEPPVVRR-------------------EENKRRR------RRMKAFTSA 46

  Fly  1121 SNVEVN--ALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRT 1183
            |.|.:.  |:|.:|..:.::..::|.|     ||.: ..||........|..||..|.:
Zfish    47 SAVSMEHIAVEFVLPTTNKNSKTLDTL-----QLDV-TGNWTVEQVKVQLWHRAVTSKL------ 99

  Fly  1184 EDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPVS 1248
                        |                   |.|.|:...:..:|  :.|......|:
Zfish   100 ------------C-------------------PEFYQKYSPDYCIL--LYQKKGNWYEI------ 125

  Fly  1249 SGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAETLLTQFFGQ 1313
                .::.:...:   :.|:.:.:.||:..  |....:.....|    |.:||. :..|....|.
Zfish   126 ----YDKQQVFQT---LDCIRYWKALRKDV--GKIHLVVRQQPA----EDSLQY-QRFLNHLIGY 176

  Fly  1314 PIGEIA---------------------------ALFSLEQGV-QTDNPEMLR---GYSELVKCLH 1347
            .:.:::                           .|:|::..: .|..||.|.   ..:.::..:|
Zfish   177 DVTDVSNVHDDELEFTRRKLLTPRKIELSDRDPNLYSMDPWMTTTPMPEYLLSKISNNHILMVIH 241

  Fly  1348 LQQQQSQTHSGDLSSSIDVCAALCLN--IQKSNNQPAAGADLLLNLADWIA-----VRTCNG--- 1402
                 .:|.|..:..|||......|.  ..|..|:.|     ||.:::.::     :|.|..
Zfish   242 -----KETTSQTIKVSIDDTPVQVLQSFFAKITNKRA-----LLGISEDVSESDFVLRVCGREEY 296

  Fly  1403 LTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYR 1467
            |..|.:   |:....:.:|           :...|.     :|..|:..||..:.::...:|
Zfish   297 LYGNNA---IKDFHWIRQC-----------LKNGEE-----IHLVLEHPPNPEQDVVQKEDW--- 339

  Fly  1468 WGKKVADSC---------CVLTQADATAISQ---------------ALDIP-QPLESEKL----- 1502
               ...|.|         ..:|:.|...:..               .:||| .|..||.:
Zfish   340 ---SQVDDCTGVAGTHEQLTITEKDHEKVFTISLWDCNRKFRVKILGIDIPVLPRNSELIVFVEA 401

  Fly  1503 -----DELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRA 1562
                 .:||                     |::..::|             |...:.|...|...
Zfish   402 SIFHGQQLL---------------------AQERTSSK-------------PFTEEVIWNTWLEF 432

  Fly  1563 IANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVKHAS 1627
            .....|..|.|..|    |....|....:...|.....:.||      |....|    |:|.|.|
Zfish   433 NIKIKDLPKGARLS----LQVSCGKAQTQTSKETECKNKSRL------LYYVNL----LLVDHRS 483

  Fly  1628 GLQEVLEQG---LHTTPIAPWK----------VIIPQLFSRLNHHEPYVRKSVC-----DLLC-- 1672
                :|.||   ||.     ||          |...:|.|..|   |....|:.     |..|
Zfish   484 ----LLRQGEFILHM-----WKMPEKSEDNSSVNADKLTSATN---PDKNNSMAVAILLDKYCYP 536

  Fly  1673 -RLAKSRPQLVIFPAVVGANR------------EQQDATAP--PATA----------RPTTEDAC 1712
             .|.||:..    |.:.|...            ||..||.|  |.|:          :....|..
Zfish   537 VALPKSKDS----PDIEGERGQREMPNHLRKQFEQIIATDPLHPLTSEDKELLWHFRQECMRDPK 597

  Fly  1713 CYGYLLGEL--SKQAPEAVQHVKL--------MVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSA 1767
            .|...|..:  .||...|:.|..|        .|.::..|..|.|       .|..:..|..::.
Zfish   598 AYPKFLSSVKWGKQEAVAITHYLLERSTIWDRSVLDVGLVLQLLD-------CHFSDENVRTIAV 655

  Fly  1768 LATDFRPDDHEGKNNRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHR 1832
            ...:...||             .:|..|..||......|   |..|...||     |...|||.:
Zfish   656 RKLETLGDD-------------DVLRYLLQLVQAVKFEP---YHDSALARF-----LLKRALRSK 699

  Fly  1833 RYPE--AW---------DKLKQLYHILQSNMIRGSGSTL-----KMQSISPVLCGIGR------- 1874
            |...  .|         ...:|.|.::....:||.|..:     |...|:..|..:.|
Zfish   700 RIGHFLFWFLRSEIAQSMHYQQRYAVILEAYLRGCGEEMLQDFRKQVEITEALQKVAREIKQISA 764

  Fly  1875 ------------MRISMPGLDAHG-PDGDQV-YIESVESSV-----C-VLPTKTKPKKVAFYGS- 1918
                        :|..:.||...| ||..:| |...:.:..     | |:.:|.||..:.|..:
Zfish   765 EKYDISAQVVFQLRQKLEGLQVLGLPDSFKVPYDPGLRAGALVIEQCKVMASKKKPLWLQFKRAD 829

  Fly  1919 ----NGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRS-D---APGNGCYRAHHYSVIPLGPQ 1975
                :......:||..:||..|..|:|.|.|..:|....| |   .|         |..|..|.:
Zfish   830 PTTLSSDTIGIIFKDGDDLRQDMLILQILLIMESIWELESLDLSLLP---------YGCISTGNK 885

  Fly  1976 SGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDP 2040
            .|:|..|...|.:..:       :....||.||         |.|
Zfish   886 IGMIEIVKDATTIANI-------QQSTVGNTGA---------FKD-------------------- 914

  Fly  2041 RRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDR 2105
                  .:|.|.|.|                :..|..:.:|:|.|||.......:..||:|:|||
Zfish   915 ------EILSQWLRE----------------KCVNEDKHQQAVDRFVFSCGGYCVATYVLGIGDR 957

  Fly  2106 HLDNVLINLGSGDIVHIDYNVCFEKGRT-LRI-PEKVPFRLTQNLVQAMGITGIEG-----PFRL 2163
            |.||::|. .:|::.|||:.......:: |.| .|:|||.||.:.:..||.||.:.     .|:.
Zfish   958 HNDNIMIT-ETGNLFHIDFGHILGNYKSFLGISKERVPFVLTPDFLYLMGTTGKKSSPNFLQFQN 1021

  Fly  2164 GCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQESADGGGAGGLGVGDL 2228
            .|......:|.....|:.|....:...:...|:.:|.:.:|.:|..            |....:.
Zfish  1022 VCLKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIREALTV------------GRSEDEA 1074

  Fly  2229 KYHKKD-----KNKG 2238
            |.|..|     ::||
Zfish  1075 KQHFLDQIEICRDKG 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	16/85 (19%)
		Rapamycin_bind	1738..1845	CDD:285924	23/117 (20%)
		PIKKc_SMG1	1894..2196	CDD:270714	73/323 (23%)
		FATC	3189..3217	CDD:280430
pik3cg	XP_021330656.1	PI3K_rbd	221..327	CDD:307097	25/134 (19%)
		C2_PI3K_class_I_gamma	366..537	CDD:176044	43/230 (19%)
		PI3Ka_I	559..735	CDD:238444	42/203 (21%)
		PI3Kc_IB_gamma	739..1105	CDD:270627	95/431 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900