DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and Pik3cd

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_038966422.1	Gene:	Pik3cd / 366508	RGDID:	1310990	Length:	1048	Species:	Rattus norvegicus

Alignment Length:	1357	Identity:	257/1357 - (18%)
Similarity:	424/1357 - (31%)	Gaps:	519/1357 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1033 GKSCKSYKWLKYAADQAA--------------GKRESALAGYRTILAEKELQSELEP--HTRQFV 1081
            |..|....|.|..:...|              ..|.:.|:..:.:|..:   ::.||  |.....
  Rat     4 GVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLSTIKQVLWHR---AQYEPFFHMLSDP 65

  Fly  1082 VSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALG 1146
            .:.:..|:....:..:| |.:|:::.     ::.|||        .:.||:|:..:....:
  Rat    66 EAYVFTCVNQTAEQQEL-EDEQRRLC-----DIQPFL--------PVLRLVAREGDRVKKL---- 112

  Fly  1147 GVFQQLSLWPSNWDESVSSSGLSERASFSSIH----------MRQRTEDIVLHKLLEDRCVPDQA 1201
             :..|:||        :...||.|   |.|:.          |||..|:...|:
  Rat   113 -INSQISL--------LIGKGLHE---FDSLRDPEVNDFRTKMRQFCEEAAAHR----------- 154

  Fly  1202 KNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKFISSAILMR 1266
            :.|...:|    |..||..:           ::..:.|....||.||:.......||
  Rat   155 QQLGWVEW----LQYSFPLQ-----------LEPSARGWRAGLLHVSNRPLLVNVKF-------- 196

  Fly  1267 CLAWTQLLRQHCAPGSWETLCLDA----------AAAAREEGNLQLAETLLTQFFGQPIGEIAAL 1321
                         .||.|:.....          |.|.|::..:          |.||:.|....
  Rat   197 -------------EGSEESFTFQVSTKDMPLALMACALRKKATV----------FRQPLVERPEE 238

  Fly  1322 FSLEQGVQTDNPEMLRG------YSELVKCLH--LQQQQSQTHSGDLSSSIDVCAALCLNIQKSN 1378
            ::|:   .....|.|.|      :..:..|||  |....:..||..:.:..|..:.....:||..
  Rat   239 YALQ---VNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR 300

  Fly  1379 NQPAA--------------------------------------------GADLLLNLADWIAVRT 1399
            .:|..                                            |.::|........|..
  Rat   301 VKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVNV 365

  Fly  1400 CNGLTTNQSPVLIQLLD------QLPECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEAL 1458
            |:      .||..|.|:      .||.....|.:...: :.:|::  ||    ..:::...|:..
  Rat   366 CS------EPVWKQRLEFDISICDLPRMARLCFALYAV-VEKAKK--AR----STKKKSKKADCP 417

  Fly  1459 IAYGN---WCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVE 1520
            ||:.|   :.|:...|..:.|..:               .|...::..||:.       ||..|.
  Rat   418 IAWANLMLFDYKDQLKTGERCLYM---------------WPSVPDEKGELMN-------PAGTVR 460

  Fly  1521 VCPDAARARDDEAAKNRLRRLTFLADKTPE-----ALDAILQIWRRAIANTYDYYKDAARSYFQY 1580
            ..|:...|    ||     .:.:|.:..|.     ||:.||::.|
  Rat   461 GNPNTESA----AA-----LVIYLPEVAPHPVYFPALEKILELGR-------------------- 496

  Fly  1581 LSFKSGSGPEKPEGE-GVVSQRERLHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAP 1644
                        .|| |.:::.|:            |:|..::.:..||  |:.|   |...:.
  Rat   497 ------------HGERGRITEEEQ------------LQLREILERRGSG--ELYE---HEKDLV- 531

  Fly  1645 WKV------IIPQLFSRL------NHHEPYVRKS-VCDLLCRLAKSRPQLVIFPAVVGANREQQD 1696
            ||:      ..|:..:||      |.||...:.| :..|||    |.|:|.:..|:     |..|
  Rat   532 WKMRHEVQEHFPEALARLLLVTKWNKHEDVAQLSQMLYLLC----SWPELPVLSAL-----ELLD 587

  Fly  1697 ATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHI---- 1757
            .:.|.           ||   :|..:             :|.||:  |..||.:.:.|..:
  Rat   588 FSFPD-----------CY---VGSFA-------------IKSLRK--LTDDELFQYLLQLVQVLK 623

  Fly  1758 YNTYVS-------RVSALATDFRPDDHEGKNNRFNVW--RPQLLADLEALVAVTSRPPETTYERS 1813
            |.:|:.       ...|||        ..|...|..|  |.::.....||
  Rat   624 YESYLDCELTKFLLGRALA--------NRKIGHFLFWHLRSEMHVPSVAL--------------- 665

  Fly  1814 FRKRFDAPIRLTVDALRHR-----RYPEAWDKLKQLYHILQSNMIRGSGSTLKMQSISPV-LCGI 1872
               ||...:........|.     :..||..|||.|...::::    |..|.|.|:...: :|
  Rat   666 ---RFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKAS----SQKTTKPQTKEMMHMC-- 721

  Fly  1873 GRMRISMPGLDAHGPDGDQVYIESVE------------SSVC------VLPTKTKP-------KK 1912
              ||             .:.|:|::.            ..||      .:.:|.||       :|
  Rat   722 --MR-------------QETYMEALSHLQSPLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYSSEK 771

  Fly  1913 VAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRS-DAPGNGCYRAHHYSVIPLGPQS 1976
            ....||.|    .:||..:||..|...:|.:.:.:.:..... |      .|...|..:|.|.::
  Rat   772 AGGAGSVG----IIFKNGDDLRQDMLTLQMIQLMDFLWKQEGLD------LRMTPYGCLPTGDRT 826

  Fly  1977 GLISWV---DGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVS 2038
            |||..|   |.:..:       |..:|.:|..|.               :||
  Rat   827 GLIEVVLHSDTIANI-------QLNKSNMAATAA---------------FNK------------- 856

  Fly  2039 DPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLG 2103
            |....|           |..:.|.:.|.|              ::..|....:...:..||:|:|
  Rat   857 DALLNW-----------LKSKNPGEALDR--------------AIEEFTLSCAGYCVATYVLGIG 896

  Fly  2104 DRHLDNVLINLGSGDIVHIDYNVCFEKGRTL----RIPEKVPFRLTQNLVQAM--GITGIEGP-- 2160
            |||.||::|. .||.:.|||:.......:|.    |  |:|||.||.:.|..:  |.|.....
  Rat   897 DRHSDNIMIR-ESGQLFHIDFGHFLGNFKTKFGINR--ERVPFILTYDFVHVIQQGKTNNSEKFE 958

  Fly  2161 -FRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLN-AKLQESA 2215
             ||..||....::|:.....|.|........|.:.:.:.|.|.|:.||. .|.:|.|
  Rat   959 RFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEA 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	21/122 (17%)
		Rapamycin_bind	1738..1845	CDD:285924	25/124 (20%)
		PIKKc_SMG1	1894..2196	CDD:270714	73/339 (22%)
		FATC	3189..3217	CDD:280430
Pik3cd	XP_038966422.1	PI3K_p85B	32..107	CDD:396665	16/91 (18%)
		PI3K_rbd	182..281	CDD:395642	26/132 (20%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	32/210 (15%)
		PI3Ka	504..687	CDD:214537	51/264 (19%)
		PI3Kc_IA_delta	679..1046	CDD:270718	96/431 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900