DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nonC and Pik3c2a

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_001101970.1 Gene:Pik3c2a / 361632 RGDID:1310389 Length:1687 Species:Rattus norvegicus


Alignment Length:1607 Identity:298/1607 - (18%)
Similarity:522/1607 - (32%) Gaps:537/1607 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1135 SEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDI---------VLHK 1190
            |.:.....|.:....:.|....:..|..:::|    :||..::.:..::|||         .|.|
  Rat   220 SPDMAKLFDKIASTSEFLKNGKARTDLEIANS----KASVCNLQISPKSEDINKFDWLDLDPLSK 280

  Fly  1191 LLEDRCV-----PDQAKN---LLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPV 1247
            ...| ||     .::.||   |.:..| |::|   .::||    ...||:.:.|:|   .||   
  Rat   281 PKID-CVEVLEHEEEKKNPVLLAEDPW-DAVL---LEERS----PTSRHLERKVNG---KSL--- 330

  Fly  1248 SSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAETLLTQFFG 1312
             ||....||:    ::::|....|:...|........|..|...::..:|..:|..|...   |.
  Rat   331 -SGATVTRSQ----SLIVRTTQVTKAQSQVSQKDPNGTSSLATGSSLLQEFEVQNEEVAA---FC 387

  Fly  1313 QPIGEIAALFSLEQGVQTD---NPEMLRGYSELVKCLHLQQ------------------QQSQTH 1356
            |.|.::...|.     .||   ||    ||  |:..:.:|:                  ||..|.
  Rat   388 QSIMKLKTKFP-----YTDHCTNP----GY--LLSPVTVQRNMCGENASVKVSIEIEGFQQPVTF 441

  Fly  1357 SGDLSSSID--VCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLP 1419
            :.|:||::|  :..|||. :....||...|:.:|         :.|......|:...:...:.:.
  Rat   442 TCDVSSTVDIIIMQALCW-VHDDLNQVDVGSYIL---------KVCGQEEVLQNNHCLGSHEHIQ 496

  Fly  1420 ECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADA 1484
            .| ...|:...|.:.....|...|..:....     ||.:....:.|:..|...:   |:|:   
  Rat   497 NC-RKWDTEIKLQLLTFSAMCQNLARTAEDD-----EAPVDLNKYLYQIEKPYKE---VMTR--- 549

  Fly  1485 TAISQALDIPQPLESEKLD----ELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLA 1545
                      .|:| |.||    ::..||.||           :..||.|.  ....:|::....
  Rat   550 ----------HPVE-ELLDSYHYQVELALQTE-----------NQHRAIDQ--VIKAVRKICSAL 590

  Fly  1546 D--KTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVDD 1608
            |  :||...:|:.:: :||:        :..|:....::..||....|....|.::....:.|..
  Rat   591 DGVETPAVTEAVKKL-KRAV--------NLPRNKSADVTSLSGGDTSKNSTRGSLNLENPVQVSM 646

  Fly  1609 SNLVTTTLRLLRLIVKHASGLQE--VLEQGLHTTPIAPWKVIIPQLF----------SRLNHHEP 1661
            .:|......||||   |.:..:.  |..||......| |.......|          :.::::|.
  Rat   647 DHLTAAIYDLLRL---HTNSCKSSTVCPQGSRNIKEA-WTATEQLQFTVYAAHGISSNWVSNYEK 707

  Fly  1662 YVRKSVCDLLCRLAKS-----RP-------------------QLVIFPAVVG------------- 1689
            |.      |:|.|:.:     :|                   :|:|||..:.             
  Rat   708 YY------LICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLF 766

  Fly  1690 ANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKELRR-------VCLLWD 1747
            ....|...::|.:..:                 ::.|||:..|.|.:.:.:|       :..||.
  Rat   767 GVLNQSSGSSPDSNKQ-----------------RKGPEALGKVSLTLFDFKRFLTCGTKLLYLWT 814

  Fly  1748 EYWIHSL--AHIYNTYVSRVSALATDFRPDDHEGKNNRFNV--WRPQLLAD------LEALVAVT 1802
            ....:|:  |....:||.....|..||       .:..|::  ..||:..:      ||||    
  Rat   815 SSHTNSIPGAIPQKSYVMERIVLQVDF-------PSPAFDIIYTSPQIDRNIIQQYKLEAL---- 868

  Fly  1803 SRPPETTYERSFR-KRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSN---MIRGSGSTLKMQ 1863
                    |...: |..|...|.:...|........|:  |:.|.:...|   .|..|....|..
  Rat   869 --------ENEIKGKLLDIVHRDSSFGLSKEDKAFLWE--KRYYCLKHPNCLPKILASAPNWKWA 923

  Fly  1864 SIS---------PVLCGIGRMRISMPGLDAHGPDGD-----QVYIESV--ESSVCVLPTKTKPKK 1912
            :::         |.||.:..:.:    |||...|.:     ..:||::  :....:||...:..|
  Rat   924 NLAKTYSLLHQWPPLCPLAALEL----LDAKFADQEVRSLAVSWIEAISDDELTDLLPQFVQALK 984

  Fly  1913 VAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVI------- 1970
            ...| .|.....||.         .|.:..:.|::::.....||..:..:.:.:..|:       
  Rat   985 YEIY-LNSSLVRFLL---------SRALGNIQIAHSLYWLLKDALHDTRFGSRYEHVLGALLSVG 1039

  Fly  1971 ------PLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFY-NK--- 2025
                  .|..|..|:..:.||.          ::..|.:|:|....:.....|....|. ||   
  Rat  1040 GKGLREELSKQMKLVQLLGGVA----------EKVRQASGSARQVVLQKSMERVQSFFLRNKCRV 1094

  Fly  2026 -LSPLLAKHNMQV-------------------SDPRRQWPISVLLQVLDELSQETPNDLLARE-- 2068
             |.|.|....:.:                   :||..: .|:|:.:|.::|.|    |:||.:  
  Rat  1095 PLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGE-EINVMFKVGEDLRQ----DMLALQMI 1154

  Fly  2069 -----LWCQAG---------------------------------------------NAAEW---- 2079
                 :|.:.|                                             ..|||    
  Rat  1155 KIMDKIWLKEGLDLRMVIFKCLSTGRDQGMVELVPASDTLRKIQVEYGVTGSFKDKPLAEWLRKY 1219

  Fly  2080 -------RQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNV---------CF 2128
                   .::...|:...:...:..||:|:.|||.||:::. .:|.:.|||:..         .|
  Rat  1220 NPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLR-STGHMFHIDFGKFLGHAQMFGSF 1283

  Fly  2129 EKGRTLRIPEKVPFRLTQNLVQAMGITGIEGP---FRLG---CEYVLKVMRKERETLLTLLEAFV 2187
            ::       ::.||.||.::  |..|.|.|.|   |:|.   |.....::||:....|.||...:
  Rat  1284 KR-------DRAPFVLTSDM--AYVINGGEKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMI 1339

  Fly  2188 YDPLVDWTTNDDAQALRRSLN------------AKLQESADGGGAGGL-----GVGDLKYHKKDK 2235
            ...|.:.|:..|.:.:|.:|.            .:|.||:.|..|...     .:..|::     
  Rat  1340 PSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATKFNFFIHNLAQLRF----- 1399

  Fly  2236 NKGKPLDSDVKRQPFLSKLGMLQKYWSTNKTELMPQLEEMEQEVGNLQAAQAKQVVAEEELVKLN 2300
             .|.|.:.    :|.||               ..|:.....|:      .:.|:|.......|.|
  Rat  1400 -SGLPSND----EPILS---------------FSPKTYSFRQD------GRIKEVSVFTYHKKYN 1438

  Fly  2301 QRSALIAEIKSLGTAIESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQL 2365
            .....|..::.|                  |.||.|          |.|     :.|::.:..:|
  Rat  1439 PDKHYIYVVRIL------------------REGHLE----------PSF-----VFRTFDEFQEL 1470

  Fly  2366 YHLLDLQGQLVKLQMESNSENAREFSALTEALQLSGLDSMRSQLNELLGRMDM--VAQKSSKHLQ 2428
            ::.|.:...|.||....|                          ..:|||..:  ||.|....|.
  Rat  1471 HNKLSIIFPLWKLPGFPN--------------------------RMVLGRTHIKDVAAKRKIELN 1509

  Fly  2429 EY-AGVMNFYPEQSHRQNLFVRFHDSFATYIQNGYTADSTTNTNSPS 2474
            .| ..:||...:.:....:...||.........|....:.|:..||:
  Rat  1510 SYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGIARSTGTSPFSPT 1556

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 1/4 (25%)
Rapamycin_bind 1738..1845 CDD:285924 24/124 (19%)
PIKKc_SMG1 1894..2196 CDD:270714 76/418 (18%)
FATC 3189..3217 CDD:280430
Pik3c2aNP_001101970.1 PI3K_rbd 411..514 CDD:279173 20/113 (18%)
C2A_PI3K_class_II 678..850 CDD:175979 31/202 (15%)
PI3Ka_II 871..1039 CDD:238441 32/183 (17%)
PI3Kc_C2_alpha 1044..1396 CDD:270720 71/376 (19%)
PX_PI3K_C2_alpha 1427..1535 CDD:132822 30/166 (18%)
C2B_PI3K_class_II 1561..1682 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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