Protein Alignment nonC and mei-41

DIOPT Version :9

• Sequence 1: NP_001284967.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_523369.2
• Gene: mei-41 / 32608
• FlyBaseID: FBgn0004367
• Length: 2517
• Species: Drosophila melanogaster
• Alignment Length: 2350
• Identity: 440/2350 - (18%)
• Similarity: 772/2350 - (32%)
• Gaps: 855/2350 - (36%)

  Fly   136 RRLINENNPTVSLELCSK----------------LDQAVRTPINMGYMTCSFVWILDNMLTLYKQ 184
            |.|:.:.....:.|:|:.                ||..||..:|        |::||.:.....
  Fly   755 RSLVAQEAVLAATEMCASQGLQTIHLWNWYKRDALDLTVRLALN--------VYLLDGVRFTRS- 810

  Fly   185 CPPPVLEECSKTLGLIGFINRKSYPIYEEFIVKNYK----------------------SSKRMQK 227
                 |...:|.||         :...:||..|.::                      .:|:|||
  Fly   811 -----LRALTKMLG---------FTCVQEFTCKYHRLLTAMVLPHCIVNPLCKGVLVLIAKQMQK 861

  Fly   228 YMIMALRATLSCDTKCELHMYA-------------DKIMLLLKDFLENAESADIFIVVSNTLVQF 279
            ::     .||...:...::.:.             :.::...:..|:...:||:...|:..|:.|
  Fly   862 HI-----GTLFSISFLRIYTHVFLTEEPELANSCIELVVSCTQSSLQQLMNADVKQTVAELLIYF 921

  Fly   280 AASYAETFECH-FTDVVDIVIGWQLEAGQPTDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVED 343
            ..:  .||... |..::      ||..|...:|.:..|..            :|:..:.::|:..
  Fly   922 NRN--PTFVMRSFQSLL------QLSIGSLEELSSQTANA------------EFANFIAERFLGV 966

  Fly   344 ITTLEE--GEPA-------NTAERVG---AFVGA----------------FNTLLK------CLA 374
            ||..|.  .||:       .|...:|   .|||:                .:||.:      ||.
  Fly   967 ITYFESCLSEPSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEPRLQRICLK 1031

  Fly   375 RMQIFVGMPTCECIVKMAVDHLIKIMPTLHLNTEALVNINELICICLLNNFTGLDPILLEQVLLD 439
            ...||:.:...: .:..::..::..:..|..:.|::..:|:|....:|.|.:.|...:.:...||
  Fly  1032 IWHIFLHVVNVQ-ELGPSLGRIVATLQPLLADNESVKQVNDLYEFIILRNASMLGTFITDLYFLD 1095

  Fly   440 QVKRMISLTELQRQSVLYLLLCTVRRLRARL-TPSLVHFIFQSNPYMTKVRLRSPGETSYKLLLR 503
            :::.:  ...:|:        | :||..|.| ...|.....||.|.:.::|
  Fly  1096 RMENV--SPSIQK--------C-IRRHTAHLDLKGLAEEENQSPPLVDQLR-------------- 1135

  Fly   504 TCQETLLIRNVPLLQQAYKYLVDDIDACLEKLLITAPRSKARKASVLLVFHLSAL--AALAKQTS 566
                        .||   |::.|:   ||:             ..|..:.||..|  ....|..|
  Fly  1136 ------------FLQ---KHITDE---CLQ-------------VRVYALQHLGDLFGRRRPKLNS 1169

  Fly   567 SIIGMYACKP---SILELLLTNCRAHELKFWSKYPAAQQAIFGLL----VVHCQANHNFRTN--- 621
            :|:.....:|   .|:.:|:..|:..:    |:...|.....|.|    ..:..:|:||.:.
  Fly  1170 TILSELPLEPMLEQIVNVLMAGCQHDD----SQLQMASAKCLGELGAIDASYLPSNYNFASPQHL 1230

  Fly   622 --------------SSLLRDQELSAENTSPTANSFASILRFLDSVLGQAHQLAPQNLRVLLQWIQ 672
                          :||.|..:.. :||. ..:||:..::...::.|    ::|:..:.:..| |
  Fly  1231 PLNILSDDFAVLALTSLCRGYQFQ-QNTK-HVDSFSLAIQETLAICG----ISPKEQKKVQLW-Q 1288

  Fly   673 MLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACIQTVLDYG---------------L 722
            .|....|:.::.::..      |.......|        .|:|..| :|               .
  Fly  1289 SLPARMRQLMEPMLHS------CYTCVHRPS--------TCLQQPL-FGSHYSHNYYEEWAFLWA 1338

  Fly   723 ERLEKY-PK-----LLILYRDTALQQLQMLSTNYHAPYFQIYAQLPL------HL------TLTG 769
            .||..| |.     ||..|:....:...||||.|  ||..::|.|..      |:      .|..
  Fly  1339 SRLIDYLPSSGRRHLLSSYKPCIKRDSNMLSTFY--PYILLHALLECTTEQRNHIQEEFMAVLQA 1401

  Fly   770 GESSMPGMASRRVSVWQQRISQYSAVRDNVFRDFFDRVQ----KPEQDSLIHCLRELFVRSCQVA 830
            .|.|...:..|:         :..|:::|.|:.|..|..    ||...:|:
  Fly  1402 NEESSSSVRGRQ---------ELGAIKENAFKQFESRKYAAGIKPLASTLV-------------- 1443

  Fly   831 PQDERQMNLSQCTKRCQRLAIAWLQFEAARYCVD-QRL--RTTVGKPQETFLGFEAIIMRHARLL 892
              .:|:.:.|:..:...:|....|.| ..|:..: ||:  |:|.|||.||
  Fly  1444 --SDRKEDSSRVPRLAGKLCAELLDF-LQRWLREWQRIHGRSTGGKPPET--------------- 1490

  Fly   893 SGCAKEIERSALDDLSLEELLSMQSNLSLLLGFLDALEKLI-----YNAAEGSAFALRPPEKQVA 952
                                  :.||...:..||:.:.||:     ||..|.:.
  Fly  1491 ----------------------IDSNYRKIHEFLNLIPKLLVSRASYNCGEYAR----------- 1522

  Fly   953 AFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILVNSKTQDPTYSQAIVYMAWSLVS 1017
                                             .:.|.:..|...:.:.....:...::.....|
  Fly  1523 ---------------------------------ALSYLESYLEEGEDKSQRLLEQFTFLVEVYGS 1554

  Fly  1018 CQEADSLRGLRLWARGKSCKSYKWLKYAAD----QAAGKRESALAGYRTILAEKELQSELEP-HT 1077
            .::.||:.|      ....:||. :....|    :...:::..:..|..:|:..:   :::| |.
  Fly  1555 LRDPDSVEG------AVQVRSYD-MSVTQDILVNRLVERQQDMITSYEQLLSSTD---QMQPDHV 1609

  Fly  1078 RQFV------VSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSE 1136
            |..:      ..:..|.:.| |.|.:|.:....|.......||             |.||
  Fly  1610 RAMIDAYLRDTPKTAQLIAD-GLWQRLSDRYSDQCFAECKSEL-------------LWRL----- 1655

  Fly  1137 ESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPDQA 1201
                      |.:.::....|||....|...|..|        |..|..|....||:.
  Fly  1656 ----------GSYDEMEELQSNWPAQCSQGCLKLR--------RPLTTRIEFDSLLDG------- 1695

  Fly  1202 KNLLDTQWRDSLLNPSFDQRSCK-----------ELTLLRHIVQGVSGGQELSLLPVSSGRCQNR 1255
                   .|:|:|.   :.|||.           :..|..|:|      .||
  Fly  1696 -------MRESVLE---ELRSCSAVQQHSYANAYDAVLKLHLV------HEL------------- 1731

  Fly  1256 SKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAETLLTQFFG-------- 1312
                                 ||:....|.|..|     |:|.|   .|.|:..:|.
  Fly  1732 ---------------------HCSQELVEKLEQD-----RDEDN---QEKLMKNYFDDWQYRLQI 1767

  Fly  1313 -QPIGEI-AALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLN-- 1373
             ||...| .:::|..:.:..:....|...:.|:.  ||:.:               .|.:.||
  Fly  1768 VQPQVRIQESIYSFRRNILAELQRRLTDRNHLLP--HLKTE---------------LARIWLNSA 1815

  Fly  1374 -IQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLAIPQAE 1437
             |.::..|.......:|..|::    ..:||...::.:|.|..||:            :|:...|
  Fly  1816 QINRNAGQLQRAQLYILKAAEY----QPSGLFIERAKLLWQKGDQV------------MAMNYLE 1864

  Fly  1438 RMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKL 1502
            ..::.:...|    ....:.|.|.....:..||
  Fly  1865 EQLSIMRSGC----QGNVKQLAAEQRHLFFRGK-------------------------------- 1893

  Fly  1503 DELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTY 1567
              .|||:.:    |..:.:|                             .||:|:.::.|||
  Fly  1894 --YLQAVYS----AESMHLC-----------------------------ADAVLKYFQEAIA--- 1920

  Fly  1568 DYYKDAARSYFQYLSF-------KSGSGPEKPEGEG-------VVSQRERLHVDDSNLVTTTLRL 1618
             .::.:...:.|...|       :.| |..:|.||.       :|:..:.|.....::..:..||
  Fly  1921 -VHRQSESCHVQMAQFLEKILEARQG-GKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRL 1983

  Fly  1619 LRLIV---------KHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDLLCRL 1674
            :.|.:         :....:.::|.......|.|.:..:..|:.|||.|....|...:.:::.:|
  Fly  1984 ISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKL 2048

  Fly  1675 AKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKEL 1739
            .::.||..::                               .||..........::..||::.:.
  Fly  2049 VEAYPQQSLW-------------------------------MLLPHFKSAKAHRIKRCKLVLTDS 2082

  Fly  1740 RRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQLLADLEALVAVTSR 1804
            |     ........|...:|:...|:..|.           |....:.|...|:||:..::...:
  Fly  2083 R-----LQNSTFQKLLQDFNSLTERLMDLT-----------NKEVTLDRTYKLSDLDTRLSKLCK 2131

  Fly  1805 PPE-TTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRGSGSTLKMQSIS-- 1866
            .|| :.....|.|.....:.|..|                      ||...||.......:::
  Fly  2132 QPEFSQILLPFEKYMQPTLPLNSD----------------------SNSSEGSHLPANQSTVNWF 2174

  Fly  1867 PVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGME 1931
            |.                     .|:||...:.||.:|.:..||||:....|:|:.|..|.|..:
  Fly  2175 PY---------------------QQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKD 2218

  Fly  1932 DLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHH---YSVIPLGPQSGLISWVDGVTPVFALYK 1993
            ||..|.|:|:|..:....:  ..|||..  .|..|   |:|:|...:.||:.|:    |..|.|:
  Fly  2219 DLRRDARLMEFNGLVKRYL--HQDAPAR--QRRLHIRTYAVLPFNEECGLVEWL----PNLASYR 2275

  Fly  1994 K-----WQQRRSQVAGNAGAGAVANVP-----RRFTDLFYNKLSPLLAKHNMQVSDPR--RQWPI 2046
            .     :.||| .|.......::| ||     .|..::|..:|.|         :.|.  ::|
  Fly  2276 SICMNLYAQRR-LVMSTRQLQSLA-VPLHESIERKREVFTKQLVP---------AHPPVFQEW-- 2327

  Fly  2047 SVLLQVLDELSQE--TPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDN 2109
                     |.|.  ||:.      |.:|.|.         ::|.::||||:||::||||||.:|
  Fly  2328 ---------LRQRFATPHS------WYEARNT---------YIRTVAVMSMVGYILGLGDRHGEN 2368

  Fly  2110 VLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRK 2174
            :|...|:||.||:|:|..|.:|..|..||.||||||.|::.|||..|:||.||..||..|:::::
  Fly  2369 ILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQ 2433

  Fly  2175 ERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKL----QESADGGGAGGLGVGDLKYH-KKD 2234
            |.:||:::|..||||.        .||..:.:..||:    |..||          .|:.| |:.
  Fly  2434 ESKTLMSILRPFVYDV--------GAQTRKGAATAKITKDVQRIAD----------RLQGHVKRQ 2480

  Fly  2235 KNKGKPLDSD 2244
            :....||.::
  Fly  2481 QANSIPLSTE 2490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	108/648 (17%)
		Rapamycin_bind	1738..1845	CDD:285924	16/107 (15%)
		PIKKc_SMG1	1894..2196	CDD:270714	106/318 (33%)
		FATC	3189..3217	CDD:280430
mei-41	NP_523369.2	UME	955..1060	CDD:214825	18/105 (17%)
		FAT	1653..1985	CDD:280429	86/528 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	104/311 (33%)
		FATC	2486..2517	CDD:280430	2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464453
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11139
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930