DRSC/TRiP Functional Genomics Resources

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Protein Alignment nonC and Pi4KIIIalpha

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster


Alignment Length:2269 Identity:408/2269 - (17%)
Similarity:706/2269 - (31%) Gaps:840/2269 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   247 MYADKIMLLLKDFLE--NAESADIFIVVSNTLVQFAA----SYAETFECHFTDVVDIVIGWQLEA 305
            ::|....||.||.||  :.:::|||     :|.|...    |::||.......::..::..|::.
  Fly   330 IFAVSKKLLTKDTLEHLDEQASDIF-----SLHQIKGYCYKSFSETLNLVLVTLLRELLQHQVDL 389

  Fly   306 GQPTDLKTHCAQVLEQL-----TPFFSKQID------------------------------FSYG 335
              ||.......:.:::|     |...:||.|                              ..:.
  Fly   390 --PTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMANAACVDLLVWA 452

  Fly   336 LLDQFVE---DITTLEEGEPANTAERVGAFVGAFNTLLKCLARMQIFVGMPTCECIVKMAVDHLI 397
            :.|:.|:   ::.:|:.|......:......|..:..|             ..|...|:.:||  
  Fly   453 IRDETVDVDYNVPSLQNGLQFLLKKEADKLCGRLSQKL-------------NLELSHKIVMDH-- 502

  Fly   398 KIMPTLHLNTEALVNINELI------CICLLNNF-TGLDPILLEQVLLDQVKRMISLTELQRQSV 455
              ||.|.:..|.|..:....      .|..|.:| ....|||.:  |.|..  |.||.:.:::..
  Fly   503 --MPLLMVCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGK--LHDHA--MQSLAQQKKEKE 561

  Fly   456 LYLLLCTVRRLRARLTPSLVHFIFQSNPYMTKVRLRSPGETSYKLLLRTCQETLLIRNVPLLQQA 520
            |......|:...:| |..:::...|..|.....|   .|..:::.|.....|.|.|    .|:.|
  Fly   562 LTPFKIAVQHSDSR-TAVVIYGDNQKPPGSGTGR---SGHAAFESLRDAAIENLSI----ALRAA 618

  Fly   521 Y---KYLVDDIDACLEKLLITAPRS---------KARKASVLLVFHLSALAALAKQTS----SII 569
            :   ::.|..:.|.:...|.||.:|         |:...|:.::..|..:|...|.||    :|:
  Fly   619 HTLDQFCVPALVANVSNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNIL 683

  Fly   570 GMYA---CK-PS-----ILE----LLLTNCRAHE----LKFWSKYPAAQQAIFGL---------- 607
            ..:.   || ||     |::    ::::.|..|.    :|.:|:. ..|.|....          
  Fly   684 QFFIQRFCKVPSEQNALIVDQLGCMIISQCETHVFDEIMKMFSRV-TVQSASLAYTSDPEHRKQF 747

  Fly   608 -----LVVHCQAN--HNFRTNSSLLR--------------DQELSAENTSPTANSFASILRFLDS 651
                 .||:...|  .|.:.::.:|.              |.|.|.:|| |.|...:|       
  Fly   748 HHVSDAVVNALGNIAANIQGDAEMLELLGKLLELFVQIGLDGERSYDNT-PGAQKASS------- 804

  Fly   652 VLGQAHQLAPQNLRVLLQWIQMLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACIQT 716
                    ...||.:|:..|.:|:|                           :|.|:::..    
  Fly   805 --------RAGNLGMLIPVIAVLVR---------------------------RLPPIKNPR---- 830

  Fly   717 VLDYGLERLEKYPKLLILYRDTALQQLQMLSTN---YHAPYF----QIYAQLPLHLTLTGGESSM 774
                  :||.|      |::|.....:.|..||   :.|.::    ||.|:.||.::.|..:|.|
  Fly   831 ------QRLHK------LFKDFWAYCVVMGFTNARLWPADWYQGVQQIAAKSPLLISQTAHKSDM 883

  Fly   775 PGMASRRVSVWQQRISQYSAVRDNVFRDFFDRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNL 839
                        :.::...|::.       |.|.:.....|:     |...|.........:::.
  Fly   884 ------------RELNYTLAIKS-------DSVNELRSQILV-----LLEHSSDNVATAINKLSF 924

  Fly   840 SQCTKRCQRLAIAWLQF---EAA---------RYCVD---QRLRTTVGK-----PQETFLGFEAI 884
            :|||   ..|::.||:.   |.|         .|..|   ||.:|.:.:     ..:.|..|..:
  Fly   925 AQCT---YLLSVYWLEMLRVENADEPSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNV 986

  Fly   885 IMRHARLLSGCAKEIERSALDDLSLEELLSMQSNLSLLLGFLDALEKLIYNAAEGSAFALRPPEK 949
            :..|        .||....|           :|..:|||.:.:.:.|.|...|:           
  Fly   987 LYAH--------DEIREKVL-----------ESQATLLLVYFNHIHKPIQMVAD----------- 1021

  Fly   950 QVAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILVNSKTQDPTYSQAIVYMAWS 1014
            |..:|.....|.. .|..|:...::.|.              |:|..|.:.||......:.:..:
  Fly  1022 QYLSFLVDRFPHL-LWNRRVLWCMLDIL--------------QLLAYSLSLDPNEETPTLRVVST 1071

  Fly  1015 LVSCQEADSL--RGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSELEPHT 1077
            ..:.|..|||  |.||             ||..||:..|....|:.     .|.:..:|.|:.:.
  Fly  1072 PYTLQLMDSLPARELR-------------LKDFADRCQGIVNEAMK-----WAPRSTRSHLQEYP 1118

  Fly  1078 RQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEVNALERLLAKSEE----- 1137
            .|..                                 .|.|...:....|.:.:::.|.:     
  Fly  1119 NQIP---------------------------------TPVLAHHSGLALAFDSVVSSSAQHTGTM 1150

  Fly  1138 ----SCSSMDALGGVFQQLSLWPSNWDESVSS--SGLSERASFSSIHMRQRTEDIVLHKLLEDRC 1196
                ||.:.|.  ..|..:....|.:...:|.  |.|||:....                |.||.
  Fly  1151 SKRPSCVNSDT--PRFVSVLCLRSKYAGEISGLLSVLSEKDKAG----------------LADRL 1197

  Fly  1197 VPD---QAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKF 1258
            |.|   ......|.:.|.:|...:.....|.|::  |.::..|:..| |.|             |
  Fly  1198 VSDVWEACAEKSDARHRGALWRATAYLIICSEIS--RKLLHAVASSQ-LEL-------------F 1246

  Fly  1259 ISSAI--LMRCLAWTQLLRQH---C----APGSWETLCLDAAAAAREEGNLQLAETLLTQFFGQP 1314
            ..||:  .:.|..|....||.   |    ...:|:|.                        |.:.
  Fly  1247 TESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTT------------------------FEKR 1287

  Fly  1315 IGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNN 1379
            :|    ||:.|..|                          ||                       
  Fly  1288 MG----LFAWETEV--------------------------TH----------------------- 1299

  Fly  1380 QPAAGADLLLNLADWIAVRTCNGLTTNQSPVLI-------QLLDQLPECPLTCDSSQPLAIPQAE 1437
             |.|..:               |......|:||       |||.::.:....|:..:       .
  Fly  1300 -PLAAYE---------------GCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDK-------V 1341

  Fly  1438 RMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCC--VLTQADATAISQALDIPQPLESE 1500
            .|...|:|.||....:..:            .::|:...|  .|.|. ..::.|...||:.|...
  Fly  1342 EMFCLLLHRCLPVLKSSKQ------------NRQVSTVGCRFKLLQC-GLSLLQGNTIPKSLSRN 1393

  Fly  1501 KLDELLQALSTEQ---PPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTPEALDAILQIWRR- 1561
            .|.|.:.:.:.:.   ||     .||:.:|                  ::..|.:..:|:.|:. 
  Fly  1394 ILRERIYSNALDYFCGPP-----TCPNQSR------------------EQLLEDIMILLKFWQTM 1435

  Fly  1562 -------AIANTYDY-YKDAARSYFQYLSFKSGSGPEKP---EGEGVVSQRERLHVDDSNLV--- 1612
                   ..:...|| ..:|:.|..|.|:.:  :.||..   .|.|:|:...|......|.|   
  Fly  1436 RSEKKHLVTSEVGDYDLTNASVSSTQMLAVR--NNPETASLISGGGLVNDYTRSMSASGNAVGMG 1498

  Fly  1613 -------------------TTTL-----RLLRL----------IVKHASGLQEVLEQGL------ 1637
                               |:||     |..||          .:|..:.:.|:|...|      
  Fly  1499 MGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITW 1563

  Fly  1638 ---HTTP---------IAPWK------------------------VIIPQLFSRLNHHEPYVRKS 1666
               ::.|         |..|:                        |.:||........:..|.:.
  Fly  1564 YNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRL 1628

  Fly  1667 VCD-------------LLC---RLAKSRPQLV-------IFPAVVGANREQQDATAPPATARPTT 1708
            ||.             .||   .|.:..|.||       :.|....|...:| ..:.|.||:   
  Fly  1629 VCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQ-YPSHPLTAQ--- 1689

  Fly  1709 EDACCYGYLLGELSKQAPEAV-QHVKLMVKELRRVCLLWDEYWIHSL-------AH--IYNTYVS 1763
                   |.:..||....|:| .::..:|:.||...:.:...:|.::       ||  |:|...:
  Fly  1690 -------YAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTN 1747

  Fly  1764 RVSALATDFRPDDHEGKNNRFNVWRPQLLADL----EALVAVTSRPPETTYERSFRKRFDAPIRL 1824
            .       :..:|.:.|:       |.|...|    ::::|..|...:..|||    .||...::
  Fly  1748 M-------YMDEDQQHKD-------PNLYEALDQLSQSIIASFSGAAKRFYER----EFDFFGKI 1794

  Fly  1825 TVDALRHRRYPEAWDKLKQLYHILQSNMIRG------------------SGSTLKMQSISPVLCG 1871
            |..:...|.:.:..::.......|....::|                  ||:.::..:.:|.|  
  Fly  1795 TAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYL-- 1857

  Fly  1872 IGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLD 1936
             .|.|:...|:         ..:|:....|...|...:..|:.....:.|  ..:||..:|:..|
  Fly  1858 -ARFRVYRCGI---------TELETRAMEVSNNPNSQEDAKMTLGVESWQ--AAIFKVGDDVRQD 1910

  Fly  1937 ERIMQFLSI-SNAIMACRSDA---PGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQ 1997
            ...:|.::| .|.......|.   |         |.|:...|..|:|..|...           :
  Fly  1911 MLALQVITIFKNIFQQVGLDLFLFP---------YRVVATAPGCGVIECVPNA-----------K 1955

  Fly  1998 RRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPN 2062
            .|.|:.....:|                                           |.|..|....
  Fly  1956 SRDQLGRQTDSG-------------------------------------------LSEYFQHQYG 1977

  Fly  2063 DLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVC 2127
            |..::|.  ||..|        .||:.|:..|:|||::.:.|||..|::|: ..|.|:|||:...
  Fly  1978 DESSKEF--QAARA--------NFVKSMAAYSLIGYLLQIKDRHNGNIMID-KDGHIIHIDFGFM 2031

  Fly  2128 FEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLK---VMRKERETLLTLL 2183
            ||......|..:...:||..:|..||.......|:..||..::   .:|..::.:::|:
  Fly  2032 FESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLV 2090

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 114/654 (17%)
Rapamycin_bind 1738..1845 CDD:285924 21/119 (18%)
PIKKc_SMG1 1894..2196 CDD:270714 61/297 (21%)
FATC 3189..3217 CDD:280430
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 36/199 (18%)
PI4Kc_III_alpha 1836..2153 CDD:270711 68/343 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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