DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and Pik3c2b

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_006249816.1	Gene:	Pik3c2b / 289021	RGDID:	1306541	Length:	1633	Species:	Rattus norvegicus

Alignment Length:	1877	Identity:	337/1877 - (17%)
Similarity:	578/1877 - (30%)	Gaps:	699/1877 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   897 KEIERSALD--DLSLEELLSMQSNLSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAAFFRLNN 959
            |.:|...:.  :|::.|.|.|:         .|||.:|.::..|..|       ||      ...
  Rat    12 KSLESVGISRKELAMAEALQME---------YDALSRLRHHKEESRA-------KQ------NTE 54

  Fly   960 PTCQSWFNRIRIGVVIIAMHVQQPELVI-------RYAQQILVNSKTQDPTYSQAIVYMAWSLVS 1017
            |:..||               .:|.|..       |...::|......|||.:...:.....|.:
  Rat    55 PSLISW---------------DEPALDFYSKPAGRRTELKLLRGLSGSDPTLNYNSISPPEELPN 104

  Fly  1018 CQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRE-SALAGYRTILAEKELQSELEPHTRQFV 1081
            ....|...|...|.:|.....|   .|..|.:.|:.. |.::|......:|.....|.|.
  Rat   105 STSQDPQPGTDPWPKGSQSGDY---LYIFDGSDGRCSLSPVSGDTDGSCKKLSPPPLPPR----- 161

  Fly  1082 VSQMMQCLQDLGQWS--QLVELK----QQQMTRPEDRELNPFLQRSNVEVNALERLLAKSEESCS 1140
                      :..|.  .|...|    ..::::|:|  :|.|   |.|| ...::||...:....
  Rat   162 ----------VSIWDAPPLPPRKGSPSPSKISQPDD--INSF---SLVE-QPSDKLLGAQDPGEG 210

  Fly  1141 SMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLL 1205
            .:...||....|.        ||...|:::  :.:.::::...:..:|         .|..:.
  Rat   211 ELPNGGGQRHVLG--------SVDYDGIND--AITRLNLKSTYDSEIL---------SDATRG-- 254

  Fly  1206 DTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKFISSAILMRCLAW 1270
               |::                          |...|.....:||:...|||.:...:..|....
  Rat   255 ---WKE--------------------------GRGPLDFSKDTSGKPVARSKTMPPQVPPRTYTP 290

  Fly  1271 TQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAETLLTQFFGQPIGEIAA----LFSLEQGVQTD 1331
            ....|::..||  :...:.||..:.....:.....|. :...:...|:||    |..|..|..|.
  Rat   291 RYANRKNATPG--KNRRISAAPVSSRTHTVTNGHELF-EVSEERDEEVAAFCHMLDILRTGSDTQ 352

  Fly  1332 NPEMLRGYSELVKCLHLQQQQSQTHSGD----------------------LSSSID--VCAALCL 1372
            :      || |..|:......|..|.||                      .||::|  :...||.
  Rat   353 D------YS-LTGCVWSTVTPSPEHLGDEVNLKVTVLCDSLREPLTFTCNCSSTVDLLIYQTLCY 410

  Fly  1373 NIQKSNN--------QPAAGADLLLN---LADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCD 1426
            ...:...        :|....:.|.|   |.....::.|.....|   :.:||::|.   .:..|
  Rat   411 THDELREVDVGDFVLKPCGLEEFLQNKHALGSHEYIQHCRKFDIN---IRLQLMEQK---AIRSD 469

  Fly  1427 SSQPLAIPQAERMVARLVHSCLQQRP------------------NYAEA-LIAYGNWCYRWGKKV 1472
            .::.:...|:...:..|:|  ||:||                  |..:| |:|.|::..:
  Rat   470 LARTVNDDQSPSTLNYLIH--LQERPVKQTISRQALSLLFDTYHNEVDAFLLAEGDFPLK----- 527

  Fly  1473 ADSCCVLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAAR---ARDDEAA 1534
            ||......:|...|:: |::.|         |:..||: :.||      ||...:   .:|....
  Rat   528 ADRVVQSVKAICNALA-AVETP---------EITSALN-QLPP------CPSRMQPKIQKDPSVL 575

  Fly  1535 KNRLRRLTFLADKTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVS 1599
            ..|..|     :|..|||.|       ||.:..:.|.....:.||               ..|..
  Rat   576 TVRENR-----EKVVEALTA-------AILDLVELYCSTFNADFQ---------------TAVPG 613

  Fly  1600 QRERLHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVR 1664
            .|:...|.::              .|.||.......|.|..||. |..         ::.|.|:.
  Rat   614 SRKHDLVQEA--------------CHFSGALAFTVYGTHRIPII-WAT---------SYEEFYLS 654

  Fly  1665 KSVCDL------LCRLAKSR--------------PQLVIFPAVVGANREQQD----AT------A 1699
               |.|      ||...::|              .|.:.||  |..||..::    ||      .
  Rat   655 ---CSLSHGGKELCSPLQTRRAHFSKYLFHLIIWDQQICFP--VQVNRLPRETLLCATLYALPIP 714

  Fly  1700 PPATARPTTEDACCYGYLLGELSKQAPEAVQHVKLMVKELRRVCL-------LW-------DEYW 1750
            ||.::....:            .|:.|||:..|...:...|:|..       ||       ...|
  Rat   715 PPGSSSEANK------------QKRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENSSARW 767

  Fly  1751 IHSLAHIYNTYVSRV----SALATDFR--PDDHEGKNNRFNVWRPQLLADLEALVAVTSRPPETT 1809
            .....|..::.:.::    ||....|.  |.|.......|...|.:   |...|..:|.:  |:.
  Rat   768 SAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREE---DQRKLKDITQK--ESL 827

  Fly  1810 Y-------ERSFRKRF-------DAPIRLT-------------------------VDA--LRHRR 1833
            |       ::.:.||:       ..|:.|.                         .||  |.|..
  Rat   828 YWLSDADKKQLWEKRYYCHTEVSSLPLVLASAPSWEWACLPDIYALLQQWTHMNHQDALGLLHAT 892

  Fly  1834 YPE--------AW----------DKLKQLYHILQ------------------------------- 1849
            :|:        .|          |.|.||...|:
  Rat   893 FPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAISDLRVTHYFFWLL 957

  Fly  1850 SNMIRGSGSTLKMQSISPVL---CGIG--------------------RMRISMP----GLDAHGP 1887
            .:.::.|..:::.|.:...|   ||.|                    ::|.:.|    |:...|
  Rat   958 KDSLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNTLAKLAQQVREATPSARQGILRAG- 1021

  Fly  1888 DGDQVYIESVE-----SSVCVLPTKTK-------PKKVAFYGSN--------------GQRYTFL 1926
                  :|.|.     :..|.||....       |:..:::.||              |:....:
  Rat  1022 ------LEEVRQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVI 1080

  Fly  1927 FKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWV-DGVTPVFA 1990
            ||..:||..|...:|.:.|.:.|                               || :|:.....
  Rat  1081 FKCGDDLRQDMLTLQMIRIMSKI-------------------------------WVQEGLDMRMV 1114

  Fly  1991 LYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDE 2055
            :::.:...|       |.|.|..:|...|      |..:..:|.:..|...|  |::      |.
  Rat  1115 IFRCFSTGR-------GKGMVEMIPNAET------LRKIQVEHGVTGSFKDR--PLA------DW 1158

  Fly  2056 LSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIV 2120
            |.:..|.:             .|:.::|..|:...:...:..|::|:.|||.||:::.. :|.:.
  Rat  1159 LQKHNPGE-------------DEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKT-TGHMF 1209

  Fly  2121 HIDYNVCFEKGRTLRIP--------EKVPFRLTQNLVQAMGITGIEGP------FRLGCEYVLKV 2171
            |||:      ||.|...        ::.||..|.::  |..|.|.:.|      |...|.....:
  Rat  1210 HIDF------GRFLGHAQMFGNIKRDRAPFVFTSDM--AYVINGGDKPSSRFHDFVDLCCQAYNL 1266

  Fly  2172 MRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQESADGGGAGGLGVGDLKYHKKDKN 2236
            :||.....|.||...                    |:..:.|.:|        :.||||   ..:
  Rat  1267 IRKHTHLFLNLLGLM--------------------LSCGIPELSD--------LEDLKY---VYD 1300

  Fly  2237 KGKPLDSDVKRQPFLSKLGMLQKYWSTNKTELMPQLEEMEQEVGNLQAAQAKQVVAEEELVKLNQ 2301
            ..:|.|::.....:.::|                    :|..:|::             ..|||.
  Rat  1301 ALRPQDTEANATTYFTRL--------------------IESSLGSV-------------ATKLNF 1332

  Fly  2302 RSALIAEIKSLGTAIESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQLY 2366
            ....:|::|..|      |.:..:|..|.|           |..|...||::.:.....:  :::
  Rat  1333 FIHNLAQMKFTG------SDDRLTLSFAPR-----------THTLKSSGRIRDVFLCRHE--KVF 1378

  Fly  2367 HLLDLQGQLVKLQMESNSENA-------REFSALTEALQL----SGLDSMRSQLNELLGRM--DM 2418
            |.......:||: |..|:..|       .||..|...|:|    |.|.|..|:.  ::||.  :.
  Rat  1379 HPSKGYIYVVKV-MRENAHEATYIQRTFEEFQELHNKLRLLFPSSFLPSFPSRF--VIGRSRGEA 1440

  Fly  2419 VAQKSSKHLQEYA-GVMNFYPEQSHRQNLFVRFHDSFATYIQNGYTADSTTNTNSPS 2474
            ||::..:.|..|. .:::..||.:....::..||.         ...|..|:..||:
  Rat  1441 VAERRKEELNGYIWHLIHAAPEVAECDLVYTFFHP---------LPRDEKTSGPSPA 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	50/258 (19%)
		Rapamycin_bind	1738..1845	CDD:285924	31/185 (17%)
		PIKKc_SMG1	1894..2196	CDD:270714	65/342 (19%)
		FATC	3189..3217	CDD:280430
Pik3c2b	XP_006249816.1	PI3K_rbd	363..465	CDD:395642	18/107 (17%)
		C2A_PI3K_class_II	621..793	CDD:175979	38/212 (18%)
		PI3Ka_II	812..980	CDD:238441	23/172 (13%)
		PI3Kc_C2_beta	986..1339	CDD:119421	84/497 (17%)
		PX_PI3K_C2_beta	1368..1476	CDD:132823	25/121 (21%)
		C2B_PI3K_class_II	1504..1626	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900