DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nonC and Atr

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_063917.1 Gene:Atr / 245000 MGIID:108028 Length:2641 Species:Mus musculus


Alignment Length:2603 Identity:511/2603 - (19%)
Similarity:890/2603 - (34%) Gaps:867/2603 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 DVAQAFANAL-LLRNMNHVVGKGQPVVQNHRK----AYQCKGDTINPMANGEDL--RLSKIIRRL 138
            ::.:|..:|| :.:::.:::|.....::...|    ..||:....|...|.:::  :..|:...|
Mouse   377 NICRALVDALGVQKHVGYLLGPFYAALKMESKEIIERIQCQAQQENLSGNNDEVSPKRRKLSSSL 441

  Fly   139 INENNPTVSLELCSKLD---------------QAVRTPINMGYMTCSFVWILDNMLTLYKQCPPP 188
            .:...|:...|....:|               ::::..:..|.:..|....|:. :|:..|....
Mouse   442 SSYKKPSRQPEEIIHVDMDKKSILWNVLKQKAESLQISLECGTLKNSVAEALEG-ITVVLQLTAL 505

  Fly   189 VLEECSKTLGLIGFINRKSYPIYEEFIVKNYKSSKRMQKYMIMALRATLSCDTKCELHMYADKIM 253
            ....||                :::....|.|..:...|.....:...:|.|       :..|::
Mouse   506 CTVHCS----------------HQDMDGHNVKDHQHKYKKKPPVVVTWMSLD-------FYTKVL 547

  Fly   254 LLLKDFLENAESADIFIVVSNTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQPTDLKTHCAQV 318
            ...:..||:.:..::.:|: :::|:               :.|.::..|::    :..|.|   |
Mouse   548 KSCRSLLESVQKLELELVI-DSMVR---------------ICDALMYMQVK----SSFKDH---V 589

  Fly   319 LEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVGAFVGAFNTLLKCLAR--MQIFVG 381
            ||:|....|....:||       .|..:|:              :..|.|.|..|::  ...:..
Mouse   590 LEELCGMLSLPWIYSY-------SDDNSLK--------------MTTFATNLLPLSQRVWDSYSP 633

  Fly   382 MPTCECIVKMAVDHLIKIMPT---LHLNTE----ALVNINELICICLLNNFTGLDPILLEQ---- 435
            ....:|:      .|:.:.|.   |...|.    ||.:.:|:|....:..|.    |||.|    
Mouse   634 QAQSKCV------FLLTLFPRRIFLEWRTAVYNWALKSSHEVIRASCVKGFF----ILLHQQNSC 688

  Fly   436 -----VLLDQVKRMISLTELQRQSVLYLLLCTVR---RLRARLTPSLVHF-IFQSNPYMTKVRLR 491
                 :|:|:||....:.:.:..|||..|:||:.   .|.:.:.|...|. :|..|     ::..
Mouse   689 NQIPKMLVDRVKDDSDMVKKEFASVLGQLVCTLHGMFYLSSSVEPCFEHMDLFSKN-----LKAT 748

  Fly   492 SPGE-TSYKLLLRTCQE--TLLIRNVP------------------------------------LL 517
            |..| :|.::...||:.  .||.:|.|                                    |:
Mouse   749 SQHECSSSQVKASTCKPFLFLLTKNTPSPVKLAFIDNLHHLCKHLDFQEDEREVKAVLGTLLNLM 813

  Fly   518 QQA-----------YKYLVDDI---DACLEKL-------------------------LITAPRSK 543
            :..           .||:::.:   |..:::|                         |.|....:
Mouse   814 EDPDKDVRIAFSGNIKYILESLNSEDGFVKELFVLRMKEAYTHAQIARNNELKDTLILTTGDIGR 878

  Fly   544 ARKASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELK---FWSKY--PAAQQA 603
            |.|..::....|..|..|..:::|:.|  |....|..|:    .|..:|   |:|:|  |..|..
Mouse   879 AAKGDLIPFALLHLLHCLLSKSASVSG--AAYTEIRALV----AAKSVKLQNFFSQYKKPICQFL 937

  Fly   604 IFGLLVVHCQANHNFRTNSSLLRDQELS-----AENT-SPTAN--SFASILRFLDSVL------- 653
            :..|......|..:....||.:|.|:::     |.|| |..||  .|..:.|||...|       
Mouse   938 VESLHSSQMTALPSAPCQSSEIRKQDVAHHREMALNTLSEIANVFDFPDLNRFLTRTLQVLLPDL 1002

  Fly   654 -GQAHQLAPQNLRVLLQWIQMLLRE----------------CRE--------------KIDL--L 685
             .:|...|...:|.|.:.:.:..||                |.:              :|:|  |
Mouse  1003 AAKASPAASALIRTLGKQLNVSRREILINNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSL 1067

  Fly   686 MEQENFRGICRN------------------IAATASKLVPLESAACI---QTVLDYGLERLEKYP 729
            :.|: |:|:...                  :|:.||...|.:....|   :.:.||      ..|
Mouse  1068 LRQD-FQGLHNELLLRIGEHYQQVFNGLSILASFASSDDPYQGPRDITSPELMADY------LQP 1125

  Fly   730 KLL-ILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQQRISQYS 793
            ||| ||    |...:|:||::....        ...:.||...|.|..|..:.||  ..|:...:
Mouse  1126 KLLGIL----AFFNMQLLSSSVGIE--------DKKMALTSLMSLMKLMGPKHVS--SVRVKMMT 1176

  Fly   794 AVRDNV-FRDFFDRVQKPEQDSLIHCLRELF------------------------------VRSC 827
            .:|..: |:|.|..:.....|..:.||...:                              :...
Mouse  1177 TLRTGLRFKDDFPELCCRAWDCFVRCLDHAYLGPLLSHVIVALLPLIHMQPKETAAIFHYLIIEN 1241

  Fly   828 QVAPQD----------------------ERQMNLSQCT--KRCQRLAIAWLQFEAARYCVDQR-- 866
            :.|.||                      |.:...|:.|  :...:|::..:|.|.    ||.|  
Mouse  1242 RDAVQDFLHEIYFLPDHPELEKIKAVLQEYRKETSETTDLQTTLQLSMKAIQHEN----VDVRIH 1302

  Fly   867 ----LRTTVGKPQETFLGF-------EAIIMR--------------HARLLSG-CAKEIERSALD 905
                |:.|:.|.||..:.:       |.:|.:              .||||.| |..|:  .|:|
Mouse  1303 ALTSLKETLYKNQEKLIKYATDSETVEPVISQLVTVILKGCQDANSQARLLCGECLGEL--GAID 1365

  Fly   906 ----DLSLEE-------LLSMQSNLSLLLGFLDALEK--LIY----NAAEGSAFALRPPEKQVAA 953
                |.|..|       .::...:||...|.|..|.:  |.|    .|.:.:|:|:    :::.:
Mouse  1366 PGRLDFSTTETQGKDFTFVTGVEDLSFAYGLLMELTRAYLAYADNSRAQDSAAYAI----QELLS 1426

  Fly   954 FF-----RLNNPTCQSWFNRIRIGVVIIAMHVQ---QPELVIRYAQQILVNSKTQD------PTY 1004
            .:     :.|.|..|.|..        ...||:   :|.|..||..    :.|:.|      |.|
Mouse  1427 IYDCREMQSNGPGYQLWKR--------FPEHVREILEPHLNTRYKS----SQKSTDWSGVTKPIY 1479

  Fly  1005 SQAI--VYMAWS---------------------------------------------LVSCQEAD 1022
            ...:  .:..||                                             |:.|.:.|
Mouse  1480 LSKLGNNFAEWSSSWAGYLITKVRDNLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQED 1544

  Fly  1023 SLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSELEPHTRQFVVSQMMQ 1087
            ...                 .||...|..|.:...|     ::.::..|:|...:.|.|.|    
Mouse  1545 QQE-----------------VYAEIMAVLKHDEQHA-----ISTQDSASDLCQLSTQTVFS---- 1583

  Fly  1088 CLQDLGQWS----QLVELKQQQMTRPEDRELNPFLQRSNVE-VNALERLLAKSEESCSSMDALGG 1147
            .|..|.||:    |.:..::....:|:..::|..|...|.| ..::.|.|              .
Mouse  1584 VLDHLTQWARHKFQALNAEKLAQNKPKGGKVNKILSNVNFEDYQSVTRFL--------------D 1634

  Fly  1148 VFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLH-----KLLEDRCVPD-----QAK 1202
            :..|.:|..:::.....:..:....||    :.::.::|..|     ||......||     .|.
Mouse  1635 LIPQDTLAVASFRSKAYTRAVMHFESF----ITEKKQNIQKHLGFLQKLYAAMHEPDGVAGVSAI 1695

  Fly  1203 NLLDTQWRDSLLNPSF-----DQRSCKELTL------LRH---IVQGVSG-GQELSLLPVSSGRC 1252
            ...:...::.:|....     |..:|.:..:      :.|   :|:.:.| ||..:::...:|..
Mouse  1696 RKAEPSLKEQILEHESIGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLGLGQLSTVITQVNGVH 1760

  Fly  1253 QNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLD------AAAAAREEGNLQLAETLL---- 1307
            .|||:            ||..|..:....:|:....|      ||.......:::|.:.||    
Mouse  1761 ANRSE------------WTDELNTYRVEAAWKLSQWDLVENYLAADGKSTTWSVRLGQLLLSAKK 1813

  Fly  1308 ---TQFF-------GQPIGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSS 1362
               |.|:       .:.|..::|. |.|:|      ...|||..:|:...|.:.:.........|
Mouse  1814 RDTTTFYDTLKLVRAEQIVPLSAA-SFERG------SYQRGYEFIVRLHMLCELEHSLKPLFRKS 1871

  Fly  1363 SIDVCAALCLN----IQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPL 1423
            ..|.|....||    ::.:.|...|...:|       |:|... |:.|:.|   ...:.:.||.|
Mouse  1872 PGDSCNEDSLNWGARLEMTQNSYRAKEPIL-------ALRRAL-LSLNKRP---DYNEMVGECWL 1925

  Fly  1424 TCDSSQPLAIPQAERMVARLVHSCLQQRPN---------YAEALIAYGNWCYRWGKKVADSCCVL 1479
                       |:.|:..:..|.  |...|         .||..:....|.  |.|.......::
Mouse  1926 -----------QSARVARKAGHH--QTAYNALLNAGESRLAELYVERAKWL--WSKGDVHQALIV 1975

  Fly  1480 TQADATAISQALDIPQ---PLESEKLDELLQALST------EQPPANCVEVCPDAARARDDEAAK 1535
            .|...     .|..|:   |.||:.:  |:...:|      .:..||.           :..|..
Mouse  1976 LQKGV-----ELCFPENKSPSESKHM--LIHGRATLLVGRFMEETANF-----------ESNAVM 2022

  Fly  1536 NRLRRLT-FLADKTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVS 1599
            .:.:.:| ||    ||        |.       |.:...|:.|.:.:...:.:..|| :|:    
Mouse  2023 KKYKDVTLFL----PE--------WE-------DGHFYLAKYYDKLMPMVTDNKMEK-QGD---- 2063

  Fly  1600 QRERLHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSR-LNHHEPYV 1663
                              |:|.||.|                           |.| |.:...::
Mouse  2064 ------------------LIRYIVLH---------------------------FGRSLQYGNQFI 2083

  Fly  1664 RKSVCDLLCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQAPEA 1728
            .:|:           |:::......||...:.:........:...:.|.....|....::.||  
Mouse  2084 YQSM-----------PRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDLAKINSVLTEHTNRLAP-- 2135

  Fly  1729 VQHVKLMVKELRRVCLLWDEYWI---HSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQ 1790
            .|.:....:.:.|:|...||.::   ..:|.::..|..:...:.|......:..:.||..     
Mouse  2136 YQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCK----- 2195

  Fly  1791 LLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQLYHILQSNMIRG 1855
                 |.|.....      .::|..|......|||             |||.:|.    :..:.|
Mouse  2196 -----EILTKAIH------MKKSLEKFVGDATRLT-------------DKLLELC----NKSVDG 2232

  Fly  1856 SGSTLKMQ-------------SISPVLCGIGRMRI----SMPGLDA-HGP-DGDQVYIESVESSV 1901
            |.|||.|.             :.|.:|..:..:.|    |:.|..| |.| .|...|:...:..|
Mouse  2233 SNSTLSMSTHFKMLKRLVEDPTFSEILIPLQSVMIPTLPSVLGAHANHDPFPGHWAYLAGFDDVV 2297

  Fly  1902 CVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGCYRAHH 1966
            .:|.:..||||::..||:|:.|..:.|..:||..|.|:|:|.|:.|  .:.|.||...  .|..|
Mouse  2298 EILSSLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLIN--KSLRKDAESR--RRELH 2358

  Fly  1967 ---YSVIPLGPQSGLISWVD---GVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNK 2025
               |:||||..:.|:|.||:   |:.|:                             .|.::..|
Mouse  2359 IRTYAVIPLNDECGIIEWVNNTAGLRPI-----------------------------LTKIYKEK 2394

  Fly  2026 LSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLAR------ELWCQA-GNAAEWRQSV 2083
            ...:..|...|...|:.. .:|..|:|..||       ||.|      |.:.:. .:...|..|.
Mouse  2395 GVYMTGKELRQCMLPKSA-ALSEKLKVFQEL-------LLPRHPPVFHEWFLRTFPDPTSWYSSR 2451

  Fly  2084 RRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNL 2148
            ..:.|..:||||:||::||||||.:|:|.:..:|:.||:|:|..|.||.|..:||.||||||.|:
Mouse  2452 SAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNM 2516

  Fly  2149 VQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQE 2213
            |..||..|.||.||..||..|::||.:||.|:::|:.|::||||:|     ::.::....|.|.|
Mouse  2517 VNGMGPMGTEGLFRRACEVTLRLMRDQREPLMSVLKTFLHDPLVEW-----SKPVKGHSKAPLNE 2576

  Fly  2214 SAD 2216
            :.:
Mouse  2577 TGE 2579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 154/809 (19%)
Rapamycin_bind 1738..1845 CDD:285924 19/109 (17%)
PIKKc_SMG1 1894..2196 CDD:270714 107/314 (34%)
FATC 3189..3217 CDD:280430
AtrNP_063917.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..447 3/23 (13%)
HEAT repeat 690..720 CDD:293787 8/29 (28%)
HEAT repeat 729..788 CDD:293787 13/63 (21%)
HEAT 1 799..835 3/35 (9%)
HEAT repeat 802..837 CDD:293787 3/34 (9%)
UME 1119..1225 CDD:214825 27/125 (22%)
HEAT 2 1329..1365 10/37 (27%)
NR_LBD 1529..>1607 CDD:299703 18/103 (17%)
FAT 1771..2092 CDD:280429 78/451 (17%)
TEL1 <2123..2641 CDD:227365 150/538 (28%)
PIKKc_ATR 2290..2564 CDD:270625 107/319 (34%)
FATC 2610..2641 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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