DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and Smg1

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_001026984.1	Gene:	Smg1 / 233789	MGIID:	1919742	Length:	3658	Species:	Mus musculus

Alignment Length:	3885	Identity:	992/3885 - (25%)
Similarity:	1579/3885 - (40%)	Gaps:	953/3885 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IHPENCNGAGTEEEASSAFHAEIDRVLLNNNGNHGDSSNEGGGGNGSGRGGATGSGNIAGLGGS- 68
            :.|.|......:....:..||:|     .|:...|.|.|.|.|.|..||         ..||..
Mouse    56 LQPSNSAVVSRQRHDDTRGHADI-----QNDEKGGYSVNGGSGENTYGR---------KSLGQEL 106

  Fly    69 --ESMWSPGGGKSHDVAQAFANALLLRNMNHVVGKGQPVVQNHRKAYQCKGDTINPMANGEDLRL 131
              .::.||    .....|..:.||..::|              ||:.:      ..|:..::.||
Mouse   107 RINNVTSP----EFTSVQHGSRALATKDM--------------RKSQE------RSMSYSDESRL 147

  Fly   132 SKIIRRLINENNPTVSLELCSKLDQAVRTPINMGYMTCSFVWILDNMLTLYKQCPPPVLEECSK- 195
            |.::||:..|::....|....:|.:.::.|.|    ....|..|||:|.....    ||.|.||
Mouse   148 SNLLRRITREDDRDRRLATVKQLKEFIQQPEN----KLVLVKQLDNILAAVHD----VLNESSKL 204

  Fly   196 ----------TLGLI-GFINRKSYPIYEEFIVKNYKSSKRMQK--YMIMALRATLSCDTKCELHM 247
                      .|||: ..::.::..|::....|...|:|...|  |:....||..:...|.....
Mouse   205 LQELRQEGACCLGLLCASLSYEAEKIFKWIFSKFSSSAKDEVKLLYLCATYRALETVGEKKAFSS 269

  Fly   248 YADKIMLLLKDFLENAESADIFIVVSNTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQPTDLK 312
            ....:|..|:..|||.::.::.......::..|..|...|..:|.|.|||::||.::..|...|.
Mouse   270 VMQLVMTSLQSILENVDTPELLCKCVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKPSLT 334

  Fly   313 THCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEE-------GE--------PANTAERVGAF 362
            ...:..|:.|.||:...:.||..||.||:||:....|       ||        |:.:..::.|.
Mouse   335 QQVSGWLQSLEPFWVADLAFSTTLLGQFLEDMEAYAEDLSHVASGESVDEDVPPPSVSLPKLAAL 399

  Fly   363 VGAFNTLLKCLA-RMQIFVGMPTCECIVKMAVDHLIKIM------PTLHLNTEALVNINELICIC 420
            :..|:|:::.:. |.....|.|..|..|   .|.|.::|      ..:..:...|...||.:.:.
Mouse   400 LRVFSTVVRSIGERFSPIRGPPITEAYV---TDVLYRVMRCVTAANQVFFSEAVLTAANECVGVL 461

  Fly   421 LLNNFTGLDP---ILLEQVL---LDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIF 479
            |    ..|||   |..:.|:   |||::...:.......|||.||...|.::..:|..|.|..:|
Mouse   462 L----GSLDPSMTIHCDMVITYGLDQLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLF 522

  Fly   480 QSNPYMTKVRLRSPGETSYKLLLRTCQETLLIRNVPLLQQAYKYLVDDIDACLEKLL--ITAPRS 542
            ..:..:..:|.....|. ..:.....|..|.::|:|:|:.|||.::.::...|..||  :..|.:
Mouse   523 IPSSKLLFLRYHKEKEV-VAVAHAVYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPDA 586

  Fly   543 KAR--------------KASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRAHELKF 593
            .:.              .|:.:::|.||||..:....:|:|||:|..|::..||..|........
Mouse   587 CSEIKHEAFQNHVFNIDNANFVVIFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDL 651

  Fly   594 WSKYPAAQQAIFGLLVVHCQANHNF-----RTNSSLLRDQELSAENTSPTANSFASILRFLDSVL 653
            ...:||.|.|:...|..||..:.:|     .::|..|.|..:.:..|:.|...|:.||..| .:|
Mouse   652 AVHFPAIQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSIILNLL-GIL 715

  Fly   654 GQAHQLAPQNLRVLLQW---IQMLLRECREKIDLLMEQENFRGICRNIAATASKLVPLESAACIQ 715
            .:...|.....::|:.|   :.:|::: .|....|....:|....:.:  .|:.||. :...|:|
Mouse   716 LKKDNLNQDTRKLLMTWALEVAVLMKK-SETYAPLFSLPSFHKFSKGL--LANTLVE-DVNICLQ 776

  Fly   716 ----------TVLDYGLERLEKYPKLLILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGG 770
                      ::.|..|:|.....::.:::..|.::|          .:.::...:||.:.|:..
Mouse   777 ACSSLHALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQ----------AFGKLLKSIPLDVVLSNN 831

  Fly   771 ---ESSMPGMASRRVSVWQQRISQYSAVRDNVF--RDFFDRVQ-----KPEQDSLIHCLRELFVR 825
               |.....:|.|         |..|....|.|  :||.|.:.     ...:....:.|..||.
Mouse   832 NHTEIQEISLALR---------SHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFY- 886

  Fly   826 SCQVAPQDER-QMNLSQCTKRCQRLAIAWLQFEAARYCVDQRLRTTVGKPQETFLGFEAIIMRHA 889
            |||  ..|:| |..:.:...:...:...|..:|||::.|..:|||.:|:.|:||...|.||...|
Mouse   887 SCQ--RLDKRDQSTIPRNLLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLA 949

  Fly   890 RLLSGCAKEIERSALDDLSLEELLSMQSNLSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAAF 954
            .......:::.:....| :.|...|.|..|.|||.:|:.||||:|||.||.|.||..|.|.:..|
Mouse   950 AHTLNPDQDVSQWTTAD-NDEGHGSNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTF 1013

  Fly   955 FRLNNPTCQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILVNSKTQDPTYSQAI------VYMAW 1013
            |..|..|||.|..|||:.::.:.:...||.:.:|:...:|...||...|....:      |..|.
Mouse  1014 FYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTNSLTQGSELEVTIMMVVEAL 1078

  Fly  1014 SLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGY------------------ 1060
            ..:.|.||  ::|:.:|:.....|:..|:...|.||.|:.|.|...|
Mouse  1079 CELHCPEA--IQGIAVWSSSAVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSFD 1141

  Fly  1061 -------------------------RTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWS---- 1096
                                     :|:|: |.:.|  .|....::.::..:|...:..|:
Mouse  1142 KSVLTLANAGRNSASPKHSLNGESRKTVLS-KSIDS--SPEVISYLGNKACECYISIADWAAVQE 1203

  Fly  1097 -----------------------------------QLVELKQQ---------------------- 1104
                                               :.||..:|
Mouse  1204 WQNAVHDLKKNSSSTSLNLKADFNYIKSLSSFESGEFVECTEQLELLPGENINLLAGGSKEKIDM 1268

  Fly  1105 -----QMTRPEDRELNPFLQRSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVS 1164
                 .|..|:.|||     :.::||    :||..|....::::.:    :|...|.|..:..|.
Mouse  1269 KKLLPNMLSPDPREL-----QKSIEV----QLLRSSVFLATALNHM----EQDQKWQSLTENVVK 1320

  Fly  1165 SSGLSERASFSSIHMRQRT--EDIVLHKLLEDRC---VPDQAKNLLDTQWRDSLLNPSFDQ--RS 1222
            ....:.|.:...:.:...|  :.:.:...|:..|   :.:...|.|.|:  |.|: |.|..  ||
Mouse  1321 YLKQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTE--DCLI-PLFSDALRS 1382

  Fly  1223 CKE------LTLLRHIVQGVSGGQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPG 1281
            ||:      :..||:.:.                  ||:       :|.:....|..:|.|..
Mouse  1383 CKQHDVRPWMQALRYTMY------------------QNQ-------LLEKIKEQTVPIRSHLM-- 1420

  Fly  1282 SWETLCLDAAAAAREEGNLQLAETLLTQFFGQPIGEIAALFSLEQGV-------QTD---NPEML 1336
               .|.|.||..||:.||:.||..||.|.....:|:......|.|..       |.|   .||:
Mouse  1421 ---ELGLTAAKFARKRGNVSLATRLLAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPEL- 1481

  Fly  1337 RGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAALCLNIQKSNNQPAAGADLLLNLADWIAV---- 1397
                ::.|...|......||:.::.||   ||   ::..||.....|.|..:|.||.|:..
Mouse  1482 ----DIEKTKLLYTAGQSTHAMEMLSS---CA---ISFCKSAKAEYAVAKSILTLAKWVQAEWKE 1536

  Fly  1398 --------------RTCNGLTTNQSPVLIQLLDQLP-------ECP-LTCDSSQPLAIPQAERMV 1440
                          :..:||:|....:|  .|.:||       |.| :..:|:..:.:.:.:.::
Mouse  1537 ISGQLRQVYRAQQQQNLSGLSTLSRNIL--ALIELPSANTVGEEHPRIESESTVHIGVGEPDFIL 1599

  Fly  1441 ARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADATAISQALDIPQPLESEKLDEL 1505
            .:|.|....|.|..|::..|..:|.||||:||.|:.   :|.:...:       .|.|..::..|
Mouse  1600 GQLYHLSSVQAPEVAKSWAALASWAYRWGRKVVDNA---SQGEGVRL-------LPREKSEVQNL 1654

  Fly  1506 LQALSTEQPPANCV-----EVCPDAARARDD------EAAKNR------------LRRLTFLADK 1547
            |....||:......     .||..|....:|      |:..|.            :....:|::.
Mouse  1655 LPDTITEEEKERIYGILGQAVCRPAGIQDEDITLQITESEDNEDDDMVDVIWRQLISSCPWLSEL 1719

  Fly  1548 TPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRE--RLHVD--- 1607
            ...|.:.::::||:.:...:..||.:..:||.:|...:|.         |:...:  |||:.
Mouse  1720 DENATEGVIKVWRKVVDRIFSLYKLSCSAYFTFLKLNAGQ---------VLLDEDDPRLHLSHRA 1775

  Fly  1608 ----DSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVC 1668
                |..:|..|||||||:||||..|::.||.||.|||.|||:.|||||||||||.|.|||:|:|
Mouse  1776 EQSTDDVIVMATLRLLRLLVKHAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSIC 1840

  Fly  1669 DLLCRLAKSRPQLVIFPAVVGA---NREQQ---------------------------DATAPPAT 1703
            :||||:|:..|.|:::||:||.   :.|.|                           :..:|||:
Mouse  1841 NLLCRVAQDSPHLILYPAIVGTISLSSESQASGNKYSSAIPTLLGNIQGEELLVSECEGGSPPAS 1905

  Fly  1704 A-----RPTT---EDAC----CYGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAH 1756
            .     .|.:   ||..    ||..::.:||...|..|..|:::|.|||||.:||||.|:..|..
Mouse  1906 QDSNKDEPKSGLNEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQ 1970

  Fly  1757 IYNTYVSRVSALATDFRPDDHEG---KNNRFNVWRPQ-------LLADLEALVAVTSRPPETTYE 1811
            .:...:.|:..|..:.:...:..   |..:..:.|.:       ::..||.:.::|:.|.||.:|
Mouse  1971 QHMYVLRRIQQLEDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHE 2035

  Fly  1812 RSFRKRFDAPIRLTVDALRHRRYP----EAWDKLKQLYHILQSNMIRGSGSTLKMQSISPVLCGI 1872
            :.|:..:...|...::.|:....|    .:|...|::...||....:.:...|::..|||.|..:
Mouse  2036 KWFQDNYGDAIDNALEKLKTPSNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLDEISPWLAAM 2100

  Fly  1873 GRMRISMPG-LDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLD 1936
            ....|::|| :.|.    |.|.|.||..::.:|||||||||:.|.||:|:.|.:||||:||||||
Mouse  2101 TNTEIALPGEVSAR----DTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLD 2161

  Fly  1937 ERIMQFLSISNAIMAC--RSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRR 1999
            |||||||||.|.:.|.  |.:.|.   :.|.||||.|||.:||||.||||.||:|.|||:||||.
Mouse  2162 ERIMQFLSIVNTMFATINRQETPR---FHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQRE 2223

  Fly  2000 SQVAGNAGAGAVAN------VPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQ 2058
            :.:.......:...      |||. ::|:|:|:.|.|....:.:...||.||:.|:..||:||.:
Mouse  2224 AALQAQKAQDSYQTPQNPSIVPRP-SELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELME 2287

  Fly  2059 ETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHID 2123
            .||.:|||:|||.......||.:..:.:.|..:||||:||:|||||||||||||::.:|::||||
Mouse  2288 ATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHID 2352

  Fly  2124 YNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVY 2188
            ||||||||::||:|||||||:|||:..|:|:||:||.|||.||.||.:||:.|||||||||||||
Mouse  2353 YNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVY 2417

  Fly  2189 DPLVDWTTNDDAQALRRSLNAKLQESADGGGAGGL--GVGDLKYHKKDKNKGKPLDSDVKRQPFL 2251
            |||||||...:|                 |.||.:  |.|.....|:.|   :.::.::.|..|.
Mouse  2418 DPLVDWTAGGEA-----------------GFAGAVYGGGGQQAESKQSK---REMEREITRSLFS 2462

  Fly  2252 SKLGMLQKYWSTNKTEL---MPQLEEMEQEVGNLQAAQAKQVVAEEELVKLNQRSALIAEIKSL- 2312
            |::..::..|..|:.|:   :|:|:....|..:||    :|:...|:|     :..|:.||:.|
Mouse  2463 SRVAEIKVNWFKNRDEMLVVLPKLDSSLDEYLSLQ----EQLTDVEKL-----QGKLLEEIEFLE 2518

  Fly  2313 GTAIESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQLYHLL--DLQG-Q 2374
            |.....|..:|...|      :||...|.:.:|... ..:|..|..:.|.:..|...  :|:. |
Mouse  2519 GAEGVDHPSHTLQHR------YSEHTQLQTQQRAVQ-EAIQVKLNEFEQWITHYQAAFNNLEATQ 2576

  Fly  2375 LVKLQMESNSE---NAREFSALTEALQLSGLDSMRSQLNELLGRMDMVAQKSS-------KHLQE 2429
            |..|..|.:::   ....:...|..||.:|...:.||..:|.|.:..:.|:..       :.|..
Mouse  2577 LASLLQEISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHH 2641

  Fly  2430 YAGVMNFYPE---QSHR--------------------QNLFVRFHDSFA-----TYIQ------- 2459
            ||.|...||:   |.||                    |.|:.::...:|     |..|
Mouse  2642 YATVALQYPKAIFQKHRIEQWKAWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFITATEM 2706

  Fly  2460 --NGYTADSTTNTNSPSSSIICKADVVGVAEAMEYSWER-LGCQLHE-------------ASKLY 2508
              ..|.||..:........:..:|..|.|.|......|| :...|||             .|.|.
Mouse  2707 TLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSLASVIISALC 2771

  Fly  2509 AANQAQALTLGAPTTA---LLSMIVQSG-------CS---------QLLLKASLV-RTLD----- 2548
            ...:...:..||.::|   |:.:..:.|       ||         |||.:..|| :.||
Mouse  2772 TLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQCHLVPQDLDIPNPV 2836

  Fly  2549 -------RAGGAFAAYEQVALASHDDGLLHHQLLFIHLVRTMLQGVLV---MTKEEDQHLAQ--- 2600
                   .|.|.:.:.::  |.|:     ..|::|...:|.:::|...   |..|.|..:.|
Mouse  2837 EASEAVHLANGVYTSLQE--LNSN-----FRQIIFPEALRCLMKGECTLESMLHELDSLIEQTTD 2894

  Fly  2601 -------LESLLSALSHLKKMFEYDLPA---NLYRLL------LLQPNLGKLSALCHLSASSLAQ 2649
                   :|||.:.|.:.....|.:..|   ::.|:|      |:||..|.:.....:||   .|
Mouse  2895 GVPLQTLVESLQAYLRNTAMGLEEETHAHYIDVARMLHAQYGELIQPRNGSVDETPKMSA---GQ 2956

  Fly  2650 LFLEA--------------TMENGHKPPDQFPVERR----------------------------- 2671
            :.|.|              .:|..:|.  :.||..|
Mouse  2957 MLLVAFDGMFAQVETAFGLLVEKLNKM--EIPVAWRKIDIIREARSTQVNFFDDDNHRQVLEEIF 3019

  Fly  2672 FLLTLQPVYDQFLLASTSLDSLVSSMQSMLEDVHDVQ-TQQIMELGLMRSCHTELNDECFFGLVS 2735
            ||..||.:.:.|.|..|...:|..|  |.|||.:.|. ..||:.:      .|...:.||    |
Mouse  3020 FLKRLQTIKEFFRLCGTFSKTLSGS--SSLEDQNTVNGPVQIVNV------KTLFRNSCF----S 3072

  Fly  2736 EALESSRTCDVREMARPMLGFIHRLQVEKLAGL----LPILTRNFYTAVGPQCLPTASCGD---- 2792
            |          .:||:|:..|......:.|.||    |.:...:|.:|:|...:......|
Mouse  3073 E----------DQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQVEAKDFGAE 3127

  Fly  2793 -PAQADHLCESLF---ISLQSDGALLQQQAEIALLS-------------------------QQVD 2828
             ....|.||:...   |.:.....|:..:|.:...|                         |:|.
Mouse  3128 SKVSVDDLCKKAVEHNIQVGKFSQLVMNRATVLASSYDTAWKKHDLVRRLETSISSCKTSLQRVQ 3192

  Fly  2829 LHTLAASAQY-WAYSEALGSQLRCGPHIVSRPK---LTAAIGECWLELDQKLTALQQLQ------ 2883
            ||.    |.: |.:.:.|          :|||:   :|.........:.:||.||.|::
Mouse  3193 LHI----AMFQWQHEDLL----------ISRPQAMSVTPPRSAILTSMKKKLHALSQIETSIGTV 3243

  Fly  2884 ----AGLESQLSQ-------------------------------LQTQRSNWNRNHIDNLLRMEQ 2913
                |.||:.:.|                               .::||:|.......|::..|.
Mouse  3244 QEKLAALEASIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRANQVTFLCSNIIHFES 3308

  Fly  2914 CNKQRTMSHVAL----------LQKMTDGA----GAVARLEQNAIVVGEEGQALVDH---LEQW- 2960
            . :.||...::|          .|:|...|    .:|:.||...:   :.....::|   ..:|
Mouse  3309 L-RTRTAEALSLDAALFELIKRCQQMCSFASQFNSSVSELELRLL---QRVDTTLEHPIGSSEWL 3369

  Fly  2961 LAAHGQWQASSSRISAVE--------------QSMVELLDPEGAIDHYWLENVQGLLEEQTCKVH 3011
            |:||.|.....|...||:              ||:|:.:.......:..|.:|:.||:...  ..
Mouse  3370 LSAHKQLTQDMSTQRAVQTEKEQQIETVCETIQSLVDSVKTVLTGHNRQLGDVKHLLKAMA--KD 3432

  Fly  3012 REIAAIEGEQQSKHRFICTLLKETLRLLENMPRFHVQS-LCSEAQAQGQGKMEYANVQLLSD--- 3072
            .|.|..:.|.......:...|.|.....:|     :|: |.:..||.||.:.: .:|::|.:
Mouse  3433 EEAALADAEDIPYESSVRQFLAEYKSWQDN-----IQTVLFTLVQAMGQVRSQ-EHVEMLQEITP 3491

  Fly  3073 HLREGQGLMQSLYMRLQELRKDICSD----------RRVLQPSMLQNWRHQLEMILTLAKQEVNE 3127
            .|:|.:...||:|..|......:.:|          ....|||.             .|....|.
Mouse  3492 TLKELKTQSQSIYNNLVSFASPLVTDAANECSSPTSSATYQPSF-------------AAAVRSNT 3543

  Fly  3128 FFKGLEDFM-QHAGETDSYEIFTHA-------KGSGN---------VHE-------QKRNAYGVS 3168
            ..|...|.| |:|.:.....:.|.|       .|:|.         |.:       |:||:|.||
Mouse  3544 GQKTQPDVMSQNAKKLIQKNLATSADTPPSTIPGTGKSIACSPKKAVRDPKTGKAVQERNSYAVS 3608

  Fly  3169 VWKKIRMKLEGRDPDSNQRSTVAEQVDYVIREACNPENLAVLYEGWTPWV 3218
            |||:::.||||||.|.|:|.:|||||||||:||.|.:|||.||||||.||
Mouse  3609 VWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV 3658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	155/712 (22%)
		Rapamycin_bind	1738..1845	CDD:285924	28/120 (23%)
		PIKKc_SMG1	1894..2196	CDD:270714	172/309 (56%)
		FATC	3189..3217	CDD:280430	21/27 (78%)
Smg1	NP_001026984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..142		7/45 (16%)
		SMG1	629..1240	CDD:292413	142/643 (22%)
		HEAT	1815..1850		25/34 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1896..1917		4/20 (20%)
		PIKKc_SMG1	2119..2424	CDD:270714	171/308 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3565..3588		4/22 (18%)
		FATC	3628..3657	CDD:280430	21/28 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849414
Domainoid	1	1.000	321	1.000	Domainoid score	I1227
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	897	1.000	Inparanoid score	I385
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45627
OrthoDB	1	1.010	-	-		D26975at2759
OrthoFinder	1	1.000	-	-		FOG0007362
OrthoInspector	1	1.000	-	-		oto92673
orthoMCL	1	0.900	-	-		OOG6_104562
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2799
SonicParanoid	1	1.000	-	-		X6240
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.700