DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonC and Pik3c3

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_852079.2	Gene:	Pik3c3 / 225326	MGIID:	2445019	Length:	887	Species:	Mus musculus

Alignment Length:	364	Identity:	74/364 - (20%)
Similarity:	136/364 - (37%)	Gaps:	109/364 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1843 QLYHILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTK 1907
            :|.|:::: :.|.||:..|.......|.|                |.:::.:..||.....|..:
Mouse   551 RLVHLMKA-VQRESGNRKKKNERLQALLG----------------DNEKMNLSDVELIPLPLEPQ 598

  Fly  1908 TK-----------------PKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSD 1955
            .|                 |.::.|...:|.:|..:||..:||..|:.|:|.:|:.:.::  |.:
Mouse   599 VKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLL--RKE 661

  Fly  1956 APGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTD 2020
               |...:...|.|:....:.|.:.::..| ||           ::|...  .|::.|..|::.
Mouse   662 ---NLDLKLTPYKVLATSTKHGFMQFIQSV-PV-----------AEVLDT--EGSIQNFFRKYA- 708

  Fly  2021 LFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRR 2085
                               |....|..:..:|:|                              .
Mouse   709 -------------------PSETGPYGISAEVMD------------------------------T 724

  Fly  2086 FVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQ 2150
            :|:..:...:|.|::|:|||||||:|:. .:|.:.|||:.  :..||..: |...|.:|.:.:|:
Mouse   725 YVKSCAGYCVITYILGVGDRHLDNLLLT-KTGKLFHIDFG--YILGRDPK-PLPPPMKLNKEMVE 785

  Fly  2151 AMGITGIE--GPFRLGCEYVLKVMRKERETLLTLLEAFV 2187
            .||.|..|  ..||..|......:|:....:|.|....|
Mouse   786 GMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMV 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	0/1 (0%)
		PIKKc_SMG1	1894..2196	CDD:270714	65/313 (21%)
		FATC	3189..3217	CDD:280430
Pik3c3	NP_852079.2	C2_PI3K_class_III	26..186	CDD:176042
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..170
		PI3Ka_III	283..503	CDD:238442
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..466
		PI3Kc_III	539..883	CDD:270628	74/364 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900