DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nonC and Prkdc

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_035289.2 Gene:Prkdc / 19090 MGIID:104779 Length:4128 Species:Mus musculus


Alignment Length:2859 Identity:514/2859 - (17%)
Similarity:912/2859 - (31%) Gaps:1068/2859 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 GGGKSHDVAQAFANALLLRNMNHVVGKGQPVVQ-NHRK-AYQCKGDTIN-PMANGEDLRLSKIIR 136
            ||...|.|:....:|:|   ....:|..|..:. :|.: .|....:.|| .:....|:.:|:::.
Mouse  1520 GGLCDHLVSLLLNSAML---STQYLGSSQRNISFSHGEYFYSLFSEVINSELLKNLDIAVSRLME 1581

  Fly   137 RLINENNP-TVSLELCSKLDQAVR-------------TPINMGYMTCSFVWILDNMLTLYKQCPP 187
            .  :.:|| .||..|...||.:.|             |.|...:..|...|..|:.    .:...
Mouse  1582 S--SSDNPKMVSTVLNGMLDTSFRDRAVQKHQGLKLATAILQNWRKCDSWWAPDSA----PESKT 1640

  Fly   188 PVLEECSKTLGLIGFINRKSYPIYEEFIVKNYKSSKRMQKYMIMALRATLSCDTKCELHMYADKI 252
            .||...:|.|.:...::..:          |:.|...     |....|:|..|||..||:....|
Mouse  1641 TVLSLLAKMLQIDSALSFDT----------NHSSFSE-----IFTTYASLLADTKLGLHLKGQAI 1690

  Fly   253 MLL-------------LKDFLENAESADIFIVVSNTLVQFAASYAETFEC--HFTDVVDIVIGWQ 302
            :||             ||..||.....: |.:.|:.....:..|....:|  .|.|.        
Mouse  1691 ILLPFFTSLREGSLENLKHILEKLIVCN-FPMKSDEFPPDSLKYNNYVDCMKKFLDA-------- 1746

  Fly   303 LEAGQPTDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVGAFVGAFN 367
            ||..|               :|           :|.|.:.||...|:   .:..|.:      |.
Mouse  1747 LELSQ---------------SP-----------MLFQLMTDILCREQ---RHIMEEL------FQ 1776

  Fly   368 TLLKCLARMQIFVGMPTCECIVKMAVDHLIKIMPTLHLNTEALVNINELICI--CLLNNFTGLDP 430
            |..|.:||..        .|:.::   :|::.:.|:....:...|:.....:  .||.       
Mouse  1777 TTFKRIARQS--------PCVTQL---NLLESVYTMFRKADLPSNVTRQAFVDRSLLT------- 1823

  Fly   431 ILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIFQSNPYMTKVRLRSPGE 495
             ||....||.:|...|          .:::..:..|::|.| .|..|.|.:.  :||        
Mouse  1824 -LLWHCDLDTLKEFFS----------RIVVDAIDVLKSRFT-KLNEFTFDTQ--ITK-------- 1866

  Fly   496 TSYKLLLRTCQETLLIRNVPLLQQAYKY---LVDDIDACLEKLLITAPRSKARKASVLLVFHLSA 557
                   :.|...:|         |..|   |.||:              .:::|.:...||.|.
Mouse  1867 -------KMCYYKML---------AVMYSRLLKDDV--------------HSKEAKINQAFHGSR 1901

  Fly   558 LA---ALAKQ---------TSSIIG---------MYACKPSILELLLTNCRAHELKFWSKY---- 597
            :|   .|.|.         |.:::|         :|.|......:.|.:|..:||||:..:    
Mouse  1902 VAEGNELTKTLLKLCHDAFTENMVGESQLLEKRRLYHCAAYNCAISLISCVFNELKFYQGFLFNE 1966

  Fly   598 -PAAQQAIFGLLV---------------------------------------VHCQANHNFRTNS 622
             |.....||..|:                                       .|..::.::.|:|
Mouse  1967 KPEKNLFIFENLIDLKRCYTFPIEVEVPMERKKKYIEIRKEARDAANGASGSPHYMSSLSYLTDS 2031

  Fly   623 SL------------LRDQELSAENTSPTANSF--------------------------------- 642
            ||            ::....|:::..||...|                                 
Mouse  2032 SLSEEMSQFDFSTGVQSYSYSSQDRKPTTGHFQRREHQDSMTQDDIMELEMDELNQHECMAPMIA 2096

  Fly   643 ----------------ASI-------LRFLDSVLGQAHQLAPQNLRVLL---------------- 668
                            .||       ::||...||.|.  ...|:|:.|                
Mouse  2097 LIKHMQRNVIAPKGEEGSIPKDLPPWMKFLHDKLGNAS--VSLNIRLFLAKLVINTEEVFRPYAK 2159

  Fly   669 QWIQMLLR--EC---REKIDLLMEQENFRGICRNIAATASKLVPLESAACI-------------- 714
            .|:..||:  .|   ||.|..:|.:         |.||......|.:...:              
Mouse  2160 HWLSPLLQLAVCENNREGIHYMMVE---------IVATILSWTGLATPTGVPKDEVLANRLLRFL 2215

  Fly   715 --------QTVLDYGLERLEKYPK-----LLILYR----------------DTALQQLQMLSTNY 750
                    :.|..:.||.::...:     |.|.||                ...:|.|.::..|.
Mouse  2216 MKHVFHPKRAVFRHNLEIIKTLVECWKECLSIPYRLIFEKFSHKDPNSKDNSVGIQLLGIVIANN 2280

  Fly   751 HAP------------------------YFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQQRISQ 791
            ..|                        |.::||.....|.|                     |.|
Mouse  2281 LPPYDPNCDITSAMYFEALVNNMSFVKYKEVYAAAAEVLGL---------------------ILQ 2324

  Fly   792 YSAVRDNVFRDF--------FDRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNL--------- 839
            |...|.:|..:.        ..:.|...:|..|.||.::   :....|..:|.:|.         
Mouse  2325 YITERKHVIAELVCELVIKQLKQHQNTMEDKFIVCLNKI---AKGFPPLADRFLNALFFLLPKFH 2386

  Fly   840 ----SQCTK----RCQRLAIAWLQ------FEAARYCVDQRLRTTVGKPQETFLGFEAIIMRHAR 890
                :.|.:    |.:.:...:||      .:..|:..|:|.:..:....:.....:.|.:|  .
Mouse  2387 GVMKTLCLEVVLCRAEEITGLYLQLKSKDFLQVMRHRDDERQKVCLDIVYKMVAKLKPIELR--E 2449

  Fly   891 LLS-----------GCAKEI------------ERSALDDLSLEELLSMQSNLSLLLGFLD---AL 929
            ||:           .|.:::            ::.:.:|...:|:..:..:: |:.|.:|   .|
Mouse  2450 LLNPVVEFVSHPSPTCREQMYNILMWIHDNYRDQESQNDEDSQEIFKLAKDV-LIQGLIDENVGL 2513

  Fly   930 EKLIYN----------------AAEGSAFALRPPEKQV-----AAFFRLN---------NP---- 960
            :.:|.|                .|..|.::   |:.:|     |..|.|.         ||    
Mouse  2514 QLIIRNFWSHETRLPSNTLDRLLALNSLYS---PKIEVHFLSLATNFLLEMTRMSPDYLNPIFEH 2575

  Fly   961 ---TCQ--------SWFNRIRIGVVIIAMHVQ---QPELVIRYAQQILVNSKTQDP--------- 1002
               .|:        .|  |.| ..|:..|.::   .|.::....|:..::.:.|.|         
Mouse  2576 PLSECEFQEYTIDPDW--RFR-STVLTPMFIETQASPSILHTQTQEGPLSDQRQKPGQVRATQQQ 2637

  Fly  1003 ---TYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTIL 1064
               |.:||.|..:                         |:.||       .|.....||.: |:.
Mouse  2638 YDFTPTQASVERS-------------------------SFDWL-------TGSSIDLLADH-TVF 2669

  Fly  1065 AEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQ--RSNVEVNA 1127
            :.:.|.|.|....::...||.|.| :.:|.     :...:::..|:|...|....  .|..::..
Mouse  2670 SSETLSSSLLFSHKRTEKSQRMSC-KSVGP-----DFGTKKLGLPDDEVDNQVKSGTPSQADILR 2728

  Fly  1128 LERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLL 1192
            |.|...|..|..|.:.|..|:.:|                ..|:...|...|:|..: :||::..
Mouse  2729 LRRRFLKDREKLSLLYAKRGLMEQ----------------KLEKDIKSEFKMKQDAQ-VVLYRSY 2776

  Fly  1193 EDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGG--QELSLLPVSSGR---- 1251
            ....:|       |.|.:.|.|.......:.|:..:.:.:...:..|  :|::....:|.:    
Mouse  2777 RHGDLP-------DIQIQHSGLITPLQAVAQKDPIIAKQLFSSLFSGILKEMNKFKTTSEKNIIT 2834

  Fly  1252 ---CQNRSKFISSAIL-----MRCLAWTQLLRQH-----CAPGSWETLCLDAAAAAREEGNLQLA 1303
               .|:.::|:::..|     :.|:  .::..||     ..|.|....||   |:.::.|.::|.
Mouse  2835 QNLLQDFNRFLNTTFLFFPPFVSCI--QEISCQHPDFLTLDPASVRVGCL---ASLQQPGGIRLL 2894

  Fly  1304 ETLLTQFFGQ--PIGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSI-- 1364
            |..|.:...:  |...:       :|.....|::|| :.||.| |:....:.....|..||.:  
Mouse  2895 EEALLRLMPKEPPTKRV-------RGKTCLPPDVLR-WMELAK-LYRSIGEYDVLRGIFSSELGT 2950

  Fly  1365 --------------DVCAALCL------NIQKSNNQPA---------AGADLLLNLADWIAVRTC 1400
                          |.|.|..|      .::..:.:|.         |..|...||:.|..:..|
Mouse  2951 TQDTQNALLAEARSDYCQAAKLYDEALNKLEWVDGEPTEAEKEFWELASLDCYNNLSKWKELEYC 3015

  Fly  1401 NGLTT--------------------------------------NQSPVLIQLLD-----QLPECP 1422
            :.:..                                      |||  |:..:|     :|.:..
Mouse  3016 STVNIVSENSLDLSKMWSEPFYQETYLPYVIRSKLKLLLQGEGNQS--LLTFVDEAMNKELQKTV 3078

  Fly  1423 LTCDSSQPLA--------IPQAERMVARLVHSCLQQRPNYA-----------------------E 1456
            |....||.|:        |.:|...:...:...:|   ||:                       |
Mouse  3079 LELQYSQELSLLYILQDDIDRATYYIKNGIQIFMQ---NYSSIDVLLYRSRLAKLQSVQTLAEIE 3140

  Fly  1457 ALIAY-----------------GNWCYR-----------WGKKVADSCCVLTQADATAISQALDI 1493
            ..:::                 ..|..|           |...:.:.|..|::     |.:.|..
Mouse  3141 EFLSFICKHGDLSSLGPLRRLLKTWTSRYPDVVTDPMHIWDDIITNRCFFLSK-----IEERLTA 3200

  Fly  1494 PQPLESEKLDELLQALSTE----QPPANC-VEVCPDAARARDDEAA---KNRLRRLTFLADKTPE 1550
            |....|..:||..:::..|    :....| ::.|....:.:..|:|   .|....:..|.:...|
Mouse  3201 PSGDHSMSVDEDEESIDREVYEPKEDVRCMLQSCRFTMKMKMIESAWKQSNFSLSMKLLKEMHKE 3265

  Fly  1551 ALDAILQIWRRAIANTYDYYKDAARSYFQ------YLSFKSGSGPEKPEGEGVVSQRERLHVDDS 1609
            :  ...:|||....::|... :..||:.|      ....|:.:..::.:....:::..:...|.|
Mouse  3266 S--KTREIWRVQWLHSYSQL-NHCRSHTQSPREQVLNMLKTITLLDESDISNYLNKNIQASCDQS 3327

  Fly  1610 NLVTTTLRLLRLIVKHASGLQEVLEQG-------LHTTPIAPWKVIIPQLFSRLNHHEPYVRKSV 1667
            .|:.||.|::...:.........||:.       |..:.....:.:|..|:.|..||   :.|:|
Mouse  3328 ILLGTTCRIMADALSREPACLSDLEENKVNSILTLSGSNAENTETVITGLYQRAFHH---LSKAV 3389

  Fly  1668 CDLLCRLAKSRPQLVIFPAVVGANR-----------EQQDATAPPATARPTTEDACCYGYLLGEL 1721
                 :.|:...||..:.....|.|           :||......:.::.|:.:...|..|:.|.
Mouse  3390 -----QSAEEETQLSCWGHEAAAERAHAYMTLVGFCDQQLRKVEESASQKTSAEMEAYPALVVEK 3449

  Fly  1722 SKQA------------PEAVQHVK--------LMVKELRRV-CLLWDEY-WI------------- 1751
            ..:|            |..:|.::        :|.||:..: |  |... ||             
Mouse  3450 MLRALKLNSSEARLKFPRLLQIIEQYSEETLNIMTKEISSIPC--WQFIGWISHMMALLDKEEAI 3512

  Fly  1752 ---HSLAHIYNTYVSR------VSALATDFRPDDHEGKNNRFNVWR------------------- 1788
               |::..|.:.|...      :|:.:..|: :...|.||:..|.|                   
Mouse  3513 AVQHTVEEIADNYPQAIIYPFIISSESYSFK-NTSSGHNNKAFVERIKSKLDHGEVIHSFINALD 3576

  Fly  1789 ----PQLL-----ADLEALVA---VTSRPPETTYERSFRKRFD------APIRLTVDALRHRRYP 1835
                |.||     :|.:..:.   |..:..|..|||.:....|      .|.|        ||:.
Mouse  3577 QLSNPDLLFKDWVSDTKDELGKNPVNKKNIEKLYERMYAALGDLRAPGLGPFR--------RRFI 3633

  Fly  1836 EAWDKLKQLYHILQSNMIRGSGS------TLKMQSISPVLCGI-GRMRISM------PG-LDAHG 1886
            :|:.|          ..::..|:      |:|:..    .|.| |.:.:.|      || |..:.
Mouse  3634 QAFGK----------EFVKSFGNGGSKLLTMKVDD----FCKITGSLLVRMKKDSKLPGNLKEYS 3684

  Fly  1887 P--------------------DGD-------QVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYT 1924
            |                    ||.       .|.|...:..|.|:.:..|||::...|.:.:.|.
Mouse  3685 PWMSEFKAQFLKNELEIPGQYDGKSKPLPEYHVRISGFDERVKVMLSLRKPKRIVIRGHDEKEYP 3749

  Fly  1925 FLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGC----YRAHHYSVIPLGPQSGLISWVDGV 1985
            ||.||.|||..|:||.|...:.|||::  .||   .|    .:...|.|:|:..:.|||.|::..
Mouse  3750 FLVKGGEDLRQDQRIEQIFEVMNAILS--QDA---ACSQRNMQLRTYRVVPMTSRLGLIEWIENT 3809

  Fly  1986 TPVFAL-----------------------YKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLS 2027
            ..:..|                       ||.|..:   |:|.:.|||..        |.|::.:
Mouse  3810 MTLKDLLLSNMSQEEKVANNSDPKAPIRDYKDWLMK---VSGKSDAGAYV--------LMYSRAN 3863

  Fly  2028 PLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVR-RFVRCMS 2091
                :....|:..||:              .:.|.|||.| .:.:...:.|...::| .|....:
Mouse  3864 ----RTETVVAFRRRE--------------SQVPPDLLKR-AFVKMSTSPEAFLALRSHFASSHA 3909

  Fly  2092 VMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKG-RTLRIPEKVPFRLTQ---NLVQAM 2152
            ::.:..:::|:|||||:|.::.:.:|.::.||:...|... :.|.:||.:|||||:   :|:..|
Mouse  3910 LLCISHWLLGIGDRHLNNFMVAMETGSVIGIDFGHAFGSATQFLPVPELMPFRLTRQFVSLMLPM 3974

  Fly  2153 GITGIEGPFRLGCEYVLKVMRKERET--LLT-LLEAFVYDPLVDWTTNDDAQALRRSLNAKLQE 2213
            ..||      |.|..::..:|..|..  ||| .:|.||.:|..||.:.:  |.:.|...:.:||
Mouse  3975 KETG------LMCTVMVHALRAFRSCAGLLTDTMEIFVKEPSFDWKSFE--QTMLRKGGSWIQE 4030

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 138/887 (16%)
Rapamycin_bind 1738..1845 CDD:285924 31/167 (19%)
PIKKc_SMG1 1894..2196 CDD:270714 90/336 (27%)
FATC 3189..3217 CDD:280430
PrkdcNP_035289.2 HEAT 1 288..323
HEAT 2 1001..1037
HEAT 3 1050..1086
Interaction with C1D. /evidence=ECO:0000250 1501..1536 5/15 (33%)
Leucine-zipper 1501..1536 5/15 (33%)
TPR 1 1720..1753 8/55 (15%)
ArAE_1_C <1766..1822 CDD:288564 11/75 (15%)
NUC194 1812..2198 CDD:285387 75/455 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2049..2071 4/21 (19%)
KIP-binding. /evidence=ECO:0000250 2432..3213 143/876 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2614..2635 3/20 (15%)
FAT 3024..3470 CDD:280429 72/466 (15%)
PIKKc_DNA-PK 3719..4014 CDD:270716 89/335 (27%)
FATC 4097..4128 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D26975at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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