Protein Alignment nonC and Y75B8A.24

DIOPT Version :9

• Sequence 1: NP_001284967.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_499596.2
• Gene: Y75B8A.24 / 176653
• WormBaseID: WBGene00013557
• Length: 2106
• Species: Caenorhabditis elegans
• Alignment Length: 2276
• Identity: 429/2276 - (18%)
• Similarity: 762/2276 - (33%)
• Gaps: 753/2276 - (33%)

  Fly   415 ELICICLLNNFTGLDPILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIF 479
            :.:.||:..|         |...|.|:..:::|.:.:.|                         |
 Worm    13 QCLAICIAQN---------ENTKLSQIFNLLALDDKEEQ-------------------------F 43

  Fly   480 QSNPYMTKVR----------LRSPGETSYKLLLRTCQETLLIRNVPLLQQA------YKYLVDDI 528
            ::.|....||          |.|.|:.:.:|             ||:|.:|      .|::.|.:
 Worm    44 EAQPLSHNVRCSLIAIANYLLHSHGQHADEL-------------VPMLLRALIALPHMKWIDDGL 95

  Fly   529 DACLEKLLITAPRSKARKASVL-LVFHL--------SALA-ALAKQTSSIIGMYACKPS------ 577
            ....:|:.|....|.....|:. |..||        ||.| |||...|||..:...:.|
 Worm    96 LNKSDKIPIQEQFSFCFNTSLSDLAAHLPRFRQQIVSAQADALACAVSSIYDVLEDQESLEHNYS 160

  Fly   578 -ILELLLTNCRAHEL-----KFWSKYPAAQ-QAIFGLLV---VHCQ----ANHNFRTNS-SLLRD 627
             :::|:   |.|..|     :|.:.|.... ..||.|.|   ..|:    |:...|.:| ....|
 Worm   161 HVIKLM---CYALGLLRSIGRFSADYDTPLISLIFPLPVDETKKCKGAGGADIKHRISSDEFTFD 222

  Fly   628 QELSAENTSP---TANSFASILRFLDSVLGQAHQL-----------APQNLRVLLQWIQMLL-RE 677
            ....|.::.|   |.:..:.::|..:. ||.:..|           :.::|..|...:|.|: .:
 Worm   223 TSCDASSSDPLLLTDSKSSRLIRMYNK-LGASFLLNNYTGGLKLTMSSEDLEKLFDSVQRLMDSK 286

  Fly   678 CREKIDLLMEQ--ENFRGICRNIAATASKLVPLESAACIQTVL-DYGLER--------------- 724
            ..|.:|.:..:  ....|:.||...:.|::..|.....::.|| .|.::.
 Worm   287 FLESLDEISGEIFSGGSGVKRNPYKSMSEITNLCCLTLLKDVLGPYSVKNSDKNQENCGNSLQEA 351

  Fly   725 ------LEKYPKLLILYRDTALQQLQM-LSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRR- 781
                  .||:.|.:.::..|||.:|.. ||:..|:                 .|||:....||:
 Worm   352 SPSSPISEKFAKEISIFSKTALSKLDAELSSLQHS-----------------SESSLSTEVSRQK 399

  Fly   782 -----VSVWQQRISQYSAVRDNVFRDFFDRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNLSQ 841
                 .:|..|.|: ::|:.|              .|:...| .|:.||  ..|.|.::.: :||
 Worm   400 LNIQSATVCLQLIA-WAAIDD--------------MDADAIC-TEIIVR--LFANQTQKTI-ISQ 445

  Fly   842 C---TKRCQRLAIAWLQFEA-ARYCVDQRLRTTVGKPQETFLGFEAIIMRHARLLSGCAKEIERS 902
            .   .|....:|....:|.| |...|.|.|:..:.:|....          .:|.|....|..:|
 Worm   446 LPLYLKAISSMATLAEKFPAVATTAVIQNLQRFLLEPAPML----------TKLASDSTLERGKS 500

  Fly   903 ALDDLSLEELLSMQSNLSLLLGFLDAL--EKLIYNAAEGSAFALRPPEKQVAAFFRLNNPTCQSW 965
            |.|.:.    .|..||     ..:||:  .||..:|...|  |::...:.:.:..|:.:.:.|..
 Worm   501 AGDVIQ----HSKSSN-----NLIDAITKRKLSLDALRNS--AIKAICRALKSSIRMESDSVQQC 554

  Fly   966 F-----------------------NRIR----IGVVII-AMHVQQPELVIRYAQQILVNSKTQ-D 1001
            .                       |.|:    |||.:: :..|:.||:|::...|...|..:| |
 Worm   555 LAGLSTKLFVCSNANNFVVSLVCENAIQTLGGIGVGLVDSTAVEVPEMVVQIYLQRFANPPSQLD 619

  Fly  1002 PTYSQAIVYM-----------AWSLVS--CQEADSLRGLRLWARG---KSCKSYKWLKYAADQAA 1050
            .|..:.:..|           .|.|.:  |.|:.:    |::::|   .:.:.|..:..|.|.|.
 Worm   620 VTMIRCLAEMWIAGARSIYENVWKLFTQICIESSN----RVYSQGNNESNDQRYTHVSLAVDVAM 680

  Fly  1051 GKRESALAGYRTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELN 1115
            .:..:.:|               ....:..::.::::....||               .|.|.:.
 Worm   681 SRMAAGVA---------------NEDDKMTLLVRLLELFVQLG---------------IEGRRVG 715

  Fly  1116 PFLQRSNVEVNA---------------LERLLAKSEES-------------CSSMDALGGVFQQL 1152
            ..:.:|.|:::.               |.|:...||.:             |:   .||...:..
 Worm   716 EKVSKSTVKMSTSAGNLGVLMPKIASLLRRMQPISEPTTKLRSLFRDFWFYCT---VLGFDVESS 777

  Fly  1153 SLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRD------ 1211
            ||||..|..:|..:........::.::|....|..  .:..|...|.:.:.:.:|...:
 Worm   778 SLWPEEWYNAVCETATKTPVLIATENLRSELIDNA--AIRSDSISPQELQEMRNTVLAELSHQAE 840

  Fly  1212 --SLLNPSFDQRSCKELTLLRHIVQGVSGGQELSLLPVSS-GRCQNRSKFISSAILMRCLA--WT 1271
              .|:| .||..:|..|..:..:       :.:.|:..:. ....:..|:|....:.:..:  ||
 Worm   841 AVPLIN-RFDFANCTYLLSVHRM-------ETMRLIHANHVDAFSSFFKYIEDKTMRKDKSGLWT 897

  Fly  1272 QLLRQHCAPGSWETLCLDAAAAAREEGNLQLAETLL--TQF----FGQPIGEI------------ 1318
            .:|.  .||..:...|  .....|.:.:....|.|:  .||    |...:.|:
 Worm   898 CMLA--AAPRIFLEWC--EKMMKRRDNDEPTEEALVWHAQFLLFKFNHHLREVRKVADACLSQLV 958

  Fly  1319 -----------------AALFSLEQGVQTD----NPEM---------------LRGYSELVKCLH 1347
                             ..|..||..:|.|    .|:.               :.|...:||...
 Worm   959 KAFPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVVKDFS 1023

  Fly  1348 LQQQQ----------SQTHSGDL------SSSIDVCAALCLNIQKSNNQPAAGADLLLNL----- 1391
            ::.:|          :.|||..|      .|..|  ||:.|.|..::.........|.:|
 Worm  1024 MRVKQILKEALRWAPASTHSNLLEYVSKFGSERD--AAMQLAIDATSEGSGKSGSYLTSLYKRSN 1086

  Fly  1392 ----ADWIAVRTCNGLTTNQSPVLIQLLDQL-PECPLTCDSSQPLAIPQA--------------- 1436
                ...:...|.:| ..:|.....||:|:| .:....|.|.:.:.:.||
 Worm  1087 YLGQVKGMLATTLSG-DIDQVTAENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRSLN 1150

  Fly  1437 ERMVARLVHSCLQQRPNYAEALIAYGNWCYRW---GKKVADSCCVLTQADATAISQALDIPQPLE 1498
            ||:::.||.:.|.   |:.|:.::.....:.|   .:..|.|..:..||.|.|.|....:.. .|
 Worm  1151 ERILSLLVRTPLL---NFTESTVSLCTMAWNWLLSARPEAHSLFLHEQARAFADSSRFGLGL-FE 1211

  Fly  1499 SEKL--DELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRR--LTFLADK-------TPEAL 1552
            .|.:  ..|.|.|  |:||                .:|..|..|  :.|:.::       :.|.|
 Worm  1212 KEVVGGSPLCQKL--ERPP----------------PSANFRPHREWIEFIGERCDVASYSSREQL 1258

  Fly  1553 DAILQIWRRAIA---NTYDYYKDAARSYFQYLSFKSGSGPEKPE-------GEGVVSQRERL--- 1604
            |.:..::.:.::   .|...:...|.|     :..|.:||.:.|       |...|..|.||
 Worm  1259 DVLEMMFSQTLSAHIGTGHLHGSTACS-----NPASLAGPSRKETINQVTRGIEAVGVRFRLLSC 1318

  Fly  1605 ----HVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQ------------LF 1653
                ...|:.|:..|..|:|         |.|.....|...|||.....|:            .|
 Worm  1319 VLGMVQQDACLLRPTNVLIR---------QRVYSCAFHYFTIAPQGPTQPEERLREDIRLLTRFF 1374

  Fly  1654 SRLNHHEPYVRKSVCDLLCRLAKSRPQLVIFPAV--VGANREQQ---DATAPPATARPTTEDACC 1713
            ..|.:.:.|::|..      |||:...||:...:  :..|.|:.   ..|...|||..|...:..
 Worm  1375 EHLKNDKHYMQKEA------LAKTDKNLVMSSTMSQMQTNFEKSLLISGTPVTATAAGTPNTSLM 1433

  Fly  1714 ------YGYLLGELSKQAPEAVQ---------HVKLMVKELRRV-----------CLLWDEY--- 1749
                  |...|...|:::..|..         ..||.::|.||:           .|:.:|.
 Worm  1434 LPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMKQRNMLMLLVANEIERL 1498

  Fly  1750 --WIHSLAHIYNTYVSRVSALA-TDFRPDDHEGKNNRF----------NVWR--PQLLADL--EA 1797
              |:|.|            ||| .|...|..|.....|          |:||  .||..|:  |.
 Worm  1499 SAWLHPL------------ALAQEDCALDSEEFLRGAFTQAKATGGEKNIWREQAQLAWDISPEL 1551

  Fly  1798 LVAVTSR---PPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWD----------KLKQLYHILQ 1849
            .:.:.||   .||..      |..|..:|...:.:.|  .|||..          :...:.|:|.
 Worm  1552 AIQLPSRFRGSPELV------KYVDVLVRGQPEPVAH--IPEALPLFLGNGSTVFETSDMSHVLT 1608

  Fly  1850 ----SNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKP 1910
                |.::..|..|.::..:.|:     .|:.::..|.::..|...:||..:..:|.........
 Worm  1609 WARCSPVMALSLLTPRIYPMHPI-----SMQYAVRVLRSYSADELLLYIPQIVQAVRYDTMGYIS 1668

  Fly  1911 KKVAFYGSNGQ----------------------RYTFLFKGMEDLHLDERIM------------- 1940
            :.:.:...:.|                      :...||:.:.|:.  ::|:
 Worm  1669 ELIIWLAGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEALNDIM--QKILSQLEGAARRFHEA 1731

  Fly  1941 ------QFLSISNAIMAC-RSDAPGNGCYRA------HHYSVIPLGPQSGL--ISWVDGVTPVFA 1990
                  |..:||..|... :.||....|.:|      ...:.:|..|::.|  :.:..| ||:.:
 Worm  1732 EFKLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETITYLPSNPEAVLLDLDYSSG-TPMQS 1795

  Fly  1991 LYK-----KWQQRRSQV--AGNAGAGAVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISV 2048
            ..|     :::.:|..|  ..:.|..|.:....:.|:....:|.        :|.|.|..|. :.
 Worm  1796 AAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELK--------KVQDSRVCWQ-AA 1851

  Fly  2049 LLQVLDELSQETPNDLLAREL-------WCQAG-------------------------------- 2074
            :.:|.|::.|    |:||.:|       |...|
 Worm  1852 IFKVGDDVRQ----DMLALQLMQLMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSKSRDQL 1912

  Fly  2075 ------------------NAAEWRQSVRR-FVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIV 2120
                              .::|..|..|| |||.|:..|:..:::.:.|||..|::|:| .|.|:
 Worm  1913 GRQTDFGLYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFSFLLQIKDRHNGNIMIDL-DGHII 1976

  Fly  2121 HIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLG---CEYVLKVMRKERETLLTL 2182
            |||:...||......:..:..|:|::.:|..||......|||..   |.:....:|...::.::|
 Worm  1977 HIDFGFMFESSPGGNLGFEPDFKLSEEMVAIMGGKMEAAPFRQFASLCVHAYLAVRPYHKSFVSL 2041

  Fly  2183 L 2183
            :
 Worm  2042 V 2042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	129/714 (18%)
		Rapamycin_bind	1738..1845	CDD:285924	33/150 (22%)
		PIKKc_SMG1	1894..2196	CDD:270714	74/408 (18%)
		FATC	3189..3217	CDD:280430
Y75B8A.24	NP_499596.2	PI4Ka	1544..1720	CDD:238443	30/190 (16%)
		PI4Kc_III_alpha	1781..2105	CDD:270711	57/277 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900