Protein Alignment nonC and age-1

DIOPT Version :9

• Sequence 1: NP_001284967.1
• Gene: nonC / 31625
• FlyBaseID: FBgn0263968
• Length: 3218
• Species: Drosophila melanogaster
• Sequence 2: NP_496462.2
• Gene: age-1 / 174762
• WormBaseID: WBGene00000090
• Length: 1182
• Species: Caenorhabditis elegans
• Alignment Length: 653
• Identity: 130/653 - (19%)
• Similarity: 237/653 - (36%)
• Gaps: 168/653 - (25%)

  Fly  1617 RLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDLLCRLAKSRPQL 1681
            :|..|:.||.||:  |||:. ....:..|:              .|::|...|||..|::.
 Worm   614 KLQMLVKKHESGI--VLEED-EQRHVWMWR--------------RYIQKQEPDLLIVLSEL---- 657

  Fly  1682 VIFPAVVGANRE-------QQDATAPPATARPTT------EDACCYGYLLGELSKQ--------- 1724
                |.|..:||       ..:...||:.|...|      .|.....:.:.:|::|
 Worm   658 ----AFVWTDRENFSELYVMLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLNEQLSPVTFHLF 718

  Fly  1725 ----------APEAVQHVKLMVKELRRVCLLWDEYWI-HSLAHIYNTYVSRVSALATDFRPDDHE 1778
                      .|.|...|.:|:. .|.:|    :|.| |.|..:....::|:.  ..|.:.:::
 Worm   719 ILPLIQALKYEPRAQSEVGMMLL-TRALC----DYRIGHRLFWLLRAEIARLR--DCDLKSEEY- 775

  Fly  1779 GKNNRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDKLKQ 1843
               .|.::.....|...|..:.:.:|..:...|.:........:...|..::.|      |:|:.
 Worm   776 ---RRISLLMEAYLRGNEEHIKIITRQVDMVDELTRISTLVKGMPKDVATMKLR------DELRS 831

  Fly  1844 LYHILQSNMIRGSGSTLKMQSI-SPVLCGIGRMRISMPGLDAHGPDGDQVYI--ESVESSVCVLP 1905
            :.|              ||::: ||:                     |.||.  |.:.....||.
 Worm   832 ISH--------------KMENMDSPL---------------------DPVYKLGEMIIDKAIVLG 861

  Fly  1906 TKTKPKKVAFYGSNGQR------YTFLFKGMEDLHLDERIMQFLSI-SNAIMACRSDAPGNGCYR 1963
            :..:|..:.:...|.:.      ...:||..:||..|..::|.|.: .|...|...|.    |
 Worm   862 SAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDMLVLQVLEVMDNIWKAANIDC----C-- 920

  Fly  1964 AHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLSP 2028
            .:.|:|:|:|...|:|..|.....:|.:             ..|.|.:....|.....|.||
 Worm   921 LNPYAVLPMGEMIGIIEVVPNCKTIFEI-------------QVGTGFMNTAVRSIDPSFMNK--- 969

  Fly  2029 LLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVM 2093
             ..:....:.|.:::           .....|.|.:..:....||  ..::.:||.||:......
 Worm   970 -WIRKQCGIEDEKKK-----------SKKDSTKNPIEKKIDNTQA--MKKYFESVDRFLYSCVGY 1020

  Fly  2094 SMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRT-LRIP-EKVPFRLTQNLVQAM-GIT 2155
            |:..|::|:.|||.||:::. ..|...|||:......|:| |.|. ::.||.||::.:..: ...
 Worm  1021 SVATYIMGIKDRHSDNLMLT-EDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVIRSGK 1084

  Fly  2156 GIEG------PFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSL--NAKLQ 2212
            .::|      .|:..|....:||...|:..::|....:...|.:.:|..|...|:::|  |.:.:
 Worm  1085 SVDGNSHELQKFKTLCVEAYEVMWNNRDLFVSLFTLMLGMELPELSTKADLDHLKKTLFCNGESK 1149

  Fly  2213 ESA 2215
            |.|
 Worm  1150 EEA 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	17/107 (16%)
		PIKKc_SMG1	1894..2196	CDD:270714	67/319 (21%)
		FATC	3189..3217	CDD:280430
age-1	NP_496462.2	PI3K_p85B	98..177	CDD:197539
		PI3K_rbd	241..360	CDD:197540
		C2_PI3K_like	420..574	CDD:176026
		PI3Ka	606..798	CDD:214537	42/219 (19%)
		PKc_like	793..1181	CDD:304357	88/438 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900