DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nonC and smg-1

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_001361976.1 Gene:smg-1 / 172418 WormBaseID:WBGene00004879 Length:2324 Species:Caenorhabditis elegans


Alignment Length:2562 Identity:603/2562 - (23%)
Similarity:1034/2562 - (40%) Gaps:607/2562 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 LCSKLDQAVRTPINMGYMTCSFVWILDNMLTLYKQCPPPVLEE--------CSKTLGLIGFI--N 204
            :.:::::.::|..|:..:...:.::|||:      |.|.:.:.        ..|.:.|:|.:  :
 Worm    29 ILARIEEILQTTKNVESLCVKWTYLLDNL------CWPSLTKHDRNDMKTLAGKVIRLVGVLLFD 87

  Fly   205 RKSYPIYEEFIVKNYKS-SKRMQK---------YMIMAL------RATLSCDTKCELHMYADKIM 253
            .:|||.:..::...|:| :|:.::         |.|:.:      ...::.||: .:....|.|:
 Worm    88 TESYPEFLIYLGTLYQSVTKKSEETRADIVFSVYFIVGVISQKTENRLIATDTE-NVEKSLDWII 151

  Fly   254 LLLKDFLENAESADI-------FIVVSNTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQPTDL 311
            .:|.:     .|..:       |::|:||   |...||..||                    :.|
 Worm   152 KVLPN-----SSISVYNHCLKGFVLVANT---FPNVYAAMFE--------------------STL 188

  Fly   312 KTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVGAF--------VGAFNT 368
            :.    :|..|..|.|.:.:|.. |:|..:.....|.| :|....|.|...        :|....
 Worm   189 RA----ILTNLPDFNSHEKNFEL-LIDTVMRFSDQLNE-KPHLAEEMVRIIRPDIKKNGLGNMRE 247

  Fly   369 LLKCLARMQIFVGMPTCECIVKMA-----VDHLIKIMPTLHLNTE---------ALVNI-----N 414
            |.|   ||::.:      .:||||     ::...:::..:.:..|         :|:.|     |
 Worm   248 LKK---RMKLTM------ALVKMAKSQKMLEETNQMISEMSIELEENGGKWSSASLITIVCDVFN 303

  Fly   415 ELICICLLNNFTGLDPILL----EQVLLDQVK--RMISLTELQRQSVLYLLLCTVRRLRAR-LTP 472
            ||:.:       |.|.:.|    |:.|.:.:|  .:.:.:.:::|:....|...|::|.|. ...
 Worm   304 ELLIL-------GKDDVKLQKGVEESLCNVLKDLNLSNQSTMEKQAFFNSLAKIVKQLPAESQVK 361

  Fly   473 SLVHFIFQSNPYMTKVRLRSPGETS---------YKLLLRTCQETLLIRNVPLLQQAY----KYL 524
            :.||.|.    :.|:..|.:|....         ||.|:......|...::..||..|    |.:
 Worm   362 TRVHQIV----FNTETGLFTPKNRDNRMFGHNMIYKDLINLVSVLLTPTSLNHLQATYTDLRKIM 422

  Fly   525 VDDIDACLEKLLITAPRSKAR-KASVLLVFHLSALAALAKQTSSIIGMYACKPSILELLLTNCRA 588
            :|.:.. |::...|......| ..|:||:| .|:|.:::...||:|.|...:|||.|...:....
 Worm   423 IDSMSR-LKQSEDTPYSDNIRWNESILLLF-FSSLQSISCAKSSLIVMMGIRPSIFEFFSSELPL 485

  Fly   589 HELKFWSKYPAAQQAIFGLLVVHCQANHNFRTNSSLLRDQELSAENTSPTANSFA--SILRFLDS 651
            .|....|.:|........:.|.|.:|:..:...|..:...:...::...|...:|  .::.....
 Worm   486 TEYWLASNHPEVYHLFITIFVGHLKAHDFYIVQSDYIVRGDSIGQSIGQTKRDYARKQVVALQKI 550

  Fly   652 VLGQAHQLAPQNLRVLLQWIQMLL-RECREKI--DLLMEQE--------------NFRGICRN-- 697
            :.....:|..:...::..|:..|: ..|..:|  |...::|              .:...|.|  
 Worm   551 INNFGDKLWKKTRLMISSWLHSLIATACEHQIGSDSFSQREWVRLRNTVIHQSVLTWNNECVNQA 615

  Fly   698 --IAATASKLVPL------------------------ESAAC-------IQTVLDYGLERLEKYP 729
              |.:||:|...|                        ||..|       :.||.....||     
 Worm   616 LTILSTATKWSELTSDIHRDIADKTKKAKWKEATTIWESGDCNTYIRQSMSTVYQMSQER----- 675

  Fly   730 KLLILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQQRISQYSA 794
                       ||..:.||::.|..|.|.....|........:|..|..|     |...:.:   
 Worm   676 -----------QQKTITSTSFGAEEFIIITNFLLKQATPTTFNSRKGQNS-----WMDEVLE--- 721

  Fly   795 VRDNVFRDFFDRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNLSQCTKRCQRLAIAWLQFEAA 859
                .|......::||  ||.:   .|.|:....                        |:..:.|
 Worm   722 ----TFTQGCRTLEKP--DSYV---PETFIEKWD------------------------WIINQTA 753

  Fly   860 RYCVDQRLRTTVGKPQETFLGFEAIIMRHAR---LLSGCAKEIERSALDDLSLEELL--SMQ-SN 918
            .:|:..:::|.:|||.:||..||..|.|.|:   :.....|::.:|:.:|.:....|  |:| ..
 Worm   754 NFCIVNKMKTPLGKPMQTFAAFENEIKRLAKEVIVRKNSDKKLNKSSTEDPNQSPPLKYSVQWLR 818

  Fly   919 LSLLLGFLDALEKLIYNAAEGSAFALRPPEKQVAA--FFRLNNPTCQSWFNRIRIGVVIIAMHVQ 981
            :.|||..:..||||:.:|..|.:......|..|::  ||.:|..:|:.|.||:....:::|....
 Worm   819 VHLLLKLIVVLEKLMNSAIHGGSSVFNLTEIPVSSRQFFTVNAASCEVWLNRVYYPALLVAYFNG 883

  Fly   982 QPELVIRYAQQILVN-SKTQDPTYSQAIV-------YMAWSLVSCQEADSLRGLRLWAR------ 1032
            ...||||:....|.: ::.:|....:.||       .|:.|:....|...:.|||...|      
 Worm   884 YYGLVIRFGSNALSHFARQKDGDNDKKIVNGVCTASLMSLSMAVLGEPMEIVGLRRKVREEFGTD 948

  Fly  1033 -GKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSELEPHTRQFVVSQMM---------- 1086
             |:|.     ::...:.|..:.|:||.....:|......:|    |.:.::...|          
 Worm   949 MGQSL-----MEALGEMANARYETALVALEAVLVTDAATNE----TLKMIIQLAMVDILNRIRLP 1004

  Fly  1087 ------------------QCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNVEV--NALERL 1131
                              ...:|......|.:.::...|..|.|::..:..|...:.  :|..:.
 Worm  1005 QATDYYKVVLFGEESNDSTITEDFRSVELLTKFEKLNNTVNEKRQVVDWSARERFQFVESAFSQT 1069

  Fly  1132 LAKSE-----ESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERAS---FSSIHMRQRTEDIVL 1188
            :.::|     :..|:|.||                     .||..:|   :|.|    .:..:::
 Worm  1070 MRRTELLDIQKDFSAMGAL---------------------ALSADSSCKLYSDI----SSTSLII 1109

  Fly  1189 HKLLEDRCVPDQAKN-LLDTQWRDSLLNPSFDQRS----------CKELTLL-RHIV----QGVS 1237
            ..|:.......|.|| |.||:        .||:..          |::|... ||..    |..:
 Worm  1110 ANLVNKMTGVSQWKNKLTDTE--------IFDRNEEGNDGDKLAICRKLMHWGRHTKSNRGQSCA 1166

  Fly  1238 GGQELSLLPVSSGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQL 1302
            ...|:..|...:..|:.....|:|||....||            :|:.|.:       |...|:|
 Worm  1167 AHSEIIRLSRKTSNCELAFFHINSAIRGEKLA------------AWQRLEV-------ERQRLKL 1212

  Fly  1303 AET----LLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSS 1363
            .:|    :..:...:..|.:|.:|:....:::|. :|:.|   ::|    ::..|:.::.|::..
 Worm  1213 VKTQNLDVRIREMNEVFGSLAEVFTTSCQLKSDF-QMVDG---MIK----EKMISEGYNEDIAKR 1269

  Fly  1364 IDVCAALCLNIQKSNNQPAAGADLLLNLADWIAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSS 1428
            .:..:...:.:          ||...:|.:     ..|.|..|..|.:|     ..|.....||.
 Worm  1270 EEHMSRASIQL----------ADFFQSLPE-----LENVLAPNLFPTII-----WSELQRRSDSL 1314

  Fly  1429 QPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNWC----------------YRWGKKVADSCC 1477
            .    .....:|..|.|...:..|:.|:|.:....|.                |::||...::..
 Worm  1315 S----AGYHGIVGSLFHLASEMCPSLAKAHLKMARWAYEIAKIKNFPAENLSFYKFGKDETENEE 1375

  Fly  1478 VLTQADATAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLT 1542
            :|...:||::            ..|::|::|..:                  ||..|.|.|    
 Worm  1376 LLKSLEATSL------------VNLEKLVRAAIS------------------DDLRANNIL---- 1406

  Fly  1543 FLADKTPEALDAILQIWRRAIANTYDYYKDAARSYFQYLSFKSGSGPEKPEGEGVVSQRERLHVD 1607
                 .|.:  ..:.||:....:...:...|..||||::...||.....|     .|::|.    
 Worm  1407 -----APNS--HFMHIWKMVRDHRTKFLSIAVTSYFQFIQNMSGDCDNLP-----YSKKEE---- 1455

  Fly  1608 DSNLVTT--TLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVIIPQLFSRLNHHEPYVRKSVCDL 1670
                 ||  |||:|.|:|||...|.:|:..||:.|.:..||.|:||||:||:|...::||::.||
 Worm  1456 -----TTLATLRILELLVKHGDVLIDVINDGLNKTNVHIWKEILPQLFARLSHPSEHIRKTLVDL 1515

  Fly  1671 LCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTED-----ACCYGYLLGELSKQAPEAVQ 1730
            :.::..:.|..|:|..|.||.....|.   ........:|     ||| ..|...:|:..|..|:
 Worm  1516 ISKICTAAPHAVVFQVVSGAASSSTDG---EELEEQQNDDRNRVRACC-EKLETNMSQSYPNLVK 1576

  Fly  1731 HVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDH-----EGKNNRFNVWRPQ 1790
            .|:..|.||.|:.||.:|.|...:..:.:....|:|.:.|:....:.     ....|...|.|.|
 Worm  1577 DVRQFVAELERINLLNEEKWSVVMGTMEHEMEKRLSLIRTENAKTESALHLTASVKNDIIVKRTQ 1641

  Fly  1791 LLAD-----LEALVAVT-SRPPETTYERSFRKRFDAPIRLTVDALRHRRY-----PE-AWDKLKQ 1843
            ||..     |:.|...| ..||::..|..|...|   ..:..:|.:..|.     || :|...|.
 Worm  1642 LLTRQIFDVLDELYQQTVIEPPKSKNEEEFVTAF---AEVLTNAFQESRISRTTSPEKSWIPFKN 1703

  Fly  1844 LY-HILQSNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVY-IESVESSVCVLPT 1906
            |. :.:..|..:|. .|.:.:.|||.|..:....:.|||.::  .:.|:|. |..|...|.:|||
 Worm  1704 LIANFVHRNSKKGM-QTFETEDISPYLASLSNSCVPMPGQES--VEFDRVVSISRVARQVTILPT 1765

  Fly  1907 KTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNG-------CYRA 1964
            ||:|||:.|.||:|::..|||||.||||||||:||||.:.|.::     .||.|       .|:|
 Worm  1766 KTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVML-----QPGKGKHRQSVAAYQA 1825

  Fly  1965 HHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQV--AGNAGAGAVANVPRRFTDLFYNKLS 2027
            |||:||||||:||||.||:|.||:|.:|:|||.:...:  |.......|..:.|. :::::|.:.
 Worm  1826 HHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKALKQATKKNGETVPEIERP-SNMYHNMIR 1889

  Fly  2028 PLLAKHNM--QVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCM 2090
            ...|.|.:  .::..|.:||..:|.:|.:.|:.:||.||::||||.:|.:|..|....:|:.|.:
 Worm  1890 LAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATTWWSVTKRYSRSL 1954

  Fly  2091 SVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGIT 2155
            :||||:|.|:|||||||||:|::|..|.:||||||:||:||:.|||||.||||||:|:..|:|.:
 Worm  1955 AVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPETVPFRLTRNMRHALGPS 2019

  Fly  2156 GIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDWTTNDDAQALRRSLNAKLQESADGGGA 2220
            .:.|.||..|.:||..:|...:.|..||:|||:|||||||:::.......||..:|         
 Worm  2020 EMYGTFRESCVHVLSTLRSGHQVLTMLLDAFVFDPLVDWTSHEHTATSGVSLALQL--------- 2075

  Fly  2221 GGLGVGDLKYHKKDKNKGKPLDSDVKRQPFLSKLGMLQKYWSTNKTEL---MPQLEE---MEQEV 2279
                   ..|....|.|.|...:|......| ::..:|..|..|:.:|   |.|:.|   :|..:
 Worm  2076 -------AVYGSNWKTKAKERLTDAMELLNL-RMSEVQTLWLANRDDLLHWMKQVTECLLIENSM 2132

  Fly  2280 GNLQAAQAKQ-VVAEEELVK-LNQRSALIAEIKSLGTAIESH--------SFNTASLRNAVRRGH 2334
            ....|..|:| |.|..||.: :.:..||..|::.|...|...        .|...:|.:.:.:||
 Worm  2133 LGANAIYAQQRVKAGTELREAVTRHHALAKELRPLIRVIGKEREEFADYLKFYKQALFDPLLKGH 2197

  Fly  2335 SEALALLSTERLPDFGRVQCILRSYGQCLQLYHLLDLQGQLVKLQMESNSENAREFSALTEALQL 2399
            |.....|..:        .|:   |...:.:.::.::.|.||.|.. :..|.....::..|....
 Worm  2198 SALRNELDID--------TCV---YNFNIVMQNIDNVFGALVNLSF-TPIETITSRTSQQEFKPP 2250

  Fly  2400 SGLDSM---------RSQLNELLGRMD 2417
            .||:::         .||..|::.|::
 Worm  2251 PGLENVWVVKQDQQENSQAREVVRRVE 2277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 126/680 (19%)
Rapamycin_bind 1738..1845 CDD:285924 30/123 (24%)
PIKKc_SMG1 1894..2196 CDD:270714 147/312 (47%)
FATC 3189..3217 CDD:280430
smg-1NP_001361976.1 SMG1 468..984 CDD:374109 115/577 (20%)
PIKKc_SMG1 1753..2060 CDD:270714 147/312 (47%)
FATC 2293..2323 CDD:367005
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166609
Domainoid 1 1.000 275 1.000 Domainoid score I934
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 519 1.000 Inparanoid score I691
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12810at33208
OrthoFinder 1 1.000 - - FOG0007362
OrthoInspector 1 1.000 - - oto18837
orthoMCL 1 0.900 - - OOG6_104562
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2799
SonicParanoid 1 1.000 - - X6240
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.920

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