DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nonC and let-363

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_491549.2 Gene:let-363 / 172167 WormBaseID:WBGene00002583 Length:2695 Species:Caenorhabditis elegans


Alignment Length:2320 Identity:486/2320 - (20%)
Similarity:832/2320 - (35%) Gaps:648/2320 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 LCSKL--DQAVRTPINMGYMTCSFVWILDNMLTLYKQCPPPVL---------------------- 190
            :||.:  ||.||  :.|..::|            :.|.|.|.|                      
 Worm   658 VCSVIVNDQDVR--VRMQVISC------------FGQMPRPFLAHLAQPEMLEVQFMALHDEKLE 708

  Fly   191 --EECSKTLGLIGFIN------RKSYPIYEEFIVKNYKSSKRMQKYMIMALRATLSCDTKCELHM 247
              :.|...||.:..:|      |....:.|...........|::::....: |.|:..:...:..
 Worm   709 MQQACVTLLGRLAELNPALVLPRLRLMLLETLSQMQQSGQARLEQHSAKMI-AQLAKQSPKFMRP 772

  Fly   248 YADKIMLLLKDFLENAES-ADIFIVVSNTLVQFAASYAETFECHFTDVVDIVIGWQLEAGQPTDL 311
            |...:|:.:...|.|.:. |::...|.|.:.:.|                 |||.          
 Worm   773 YVGSLMIAMIPKLRNDQKYAEVTAQVLNAVSEIA-----------------VIGG---------- 810

  Fly   312 KTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVGAFVGAFNTLLKCLARM 376
                |::::.|.|.|.|        |...:.|.::|.:.|.|..|      :|.       :.|.
 Worm   811 ----AEIVKNLKPLFEK--------LTHMINDSSSLHKREAALRA------IGG-------ICRS 850

  Fly   377 QIFVGMPTCECIVKMAVDHLIKIMPTLHLNT---EALVNINELICICLLNN--FTGLDPILLEQV 436
            ..:|..|..:  ....:|.|::|:.|:..||   ||:..:..|..|....:  |||  .:.....
 Worm   851 TAYVVDPYRD--YPSLLDDLLRILKTVMSNTMRREAIKTLGILGAIDPYTHKVFTG--SVQSSTA 911

  Fly   437 LLDQVKRMISLTELQ--RQSVLYLL---LCTVRRLRARLTPSLVHFIFQSNPYMTKVRL------ 490
            :...:...||.|:.:  ||.:::..   .||:......:|.:.:..:.|.....:...:      
 Worm   912 ISTALSLPISETDSKDPRQDIIHWFNYEKCTLEEFYPAITIANLMLMMQDEDSQSYAEIAQAIVT 976

  Fly   491 --RSPG-------ETSYKLLLRTCQETLLIRNVPLLQQAYKYLVDDIDACLEKLLITAPRSKA-- 544
              ||.|       |.....|:..|:......|...|::.:...:.:..|.:.|  ..||...|  
 Worm   977 IFRSLGDMAPLYTEQVIPRLIEVCRRATESSNRANLREFFLQQLANFVAIIRK--HAAPYMPAIF 1039

  Fly   545 --------RKASVLLVFHLSALAAL--------AKQTSSIIGMYACKPSILELLLTNCRAHELKF 593
                    ...||.:|. :..|..:        :|.|..:|      |.:|.:|.|: :..|...
 Worm  1040 TIIADAWKEDISVKMVV-IEVLTDMGTAIGNDFSKYTGELI------PYLLTVLQTD-KTKERVL 1096

  Fly   594 WSKYPAAQQAIFGLLVVHCQANHNFRTNSSLL-----RDQELSAENTSPTANSFASILRFLDSVL 653
            ..|...:.|.:     .||...|.......||     ...:||..||:            |.:||
 Worm  1097 TVKVMESIQKL-----THCIVQHLHLVLPPLLIILDDFSLKLSIRNTA------------LSTVL 1144

  Fly   654 GQAHQL-----APQNLRVLLQWIQML-LRECREKIDLLMEQENFRGICRNIAATASKLVPLESAA 712
            ....|:     ||   |::..|...: ..|.|:|:.||:.:         |.....|...:....
 Worm  1145 HMTQQVDVSAYAP---RMMQSWHHNISTAEMRDKLLLLLIE---------IIKQLGKFFDIFKRG 1197

  Fly   713 CIQTVLDYGLERLEKYPKLLILYRDTALQQLQM----------LSTNYHAPYF-----------Q 756
            ..|.:.||.|::...|.:    ||..| |:.||          ..:|.:..|.           .
 Worm  1198 VDQKLRDYNLDKSVHYEQ----YRKLA-QRAQMSRDVLTSSVFAGSNGNIQYSSTQAGMRGQANN 1257

  Fly   757 IYAQLPLHLTLTGGESSMPGMASR--------RVSVWQQRISQYSAVRDNVFRDFFDRV------ 807
            :||...||..|..|  |:...|||        |..|.::...:...|.....|...:.|      
 Worm  1258 VYANNDLHERLMNG--SIDSGASRQDNRDDYYRYGVEEKISEEVPKVAPTTARPTSELVTVQITK 1320

  Fly   808 QKPEQDSLIHCLRELFVRSCQVAPQ--DERQMNLSQCTKRCQRLAIAWLQFEAARYCVDQRLRTT 870
            |:..:|:|:              ||  :|...:..:..:...::.|.:|.:.::   ...|..::
 Worm  1321 QRLNKDALM--------------PQWKNENLTSKDEWLQWLMKIRIGFLTYGSS---PSLRAASS 1368

  Fly   871 VGKPQETFLG---FEAIIMRHARLLSGCAKEIERSALDDLS----------LEELLSMQSNLSLL 922
            :| .|...|.   |.|..|       ....|::....:||:          :.||:....||:  
 Worm  1369 LG-DQHPHLARDLFPAAFM-------SVWTELDSDVQNDLTSCLLRAISTGIPELIQTILNLA-- 1423

  Fly   923 LGFLDALEK---------LIYNAAEGSAFALRPPEKQVAAF-------------FRLNNPTCQS- 964
             .|:|..||         |...|.:..|||.....|:::..             .:|....||| 
 Worm  1424 -EFMDHSEKGPLPISHDVLGRWAEQTKAFAKACRYKEMSVLKKSGSMQTTFTRKVKLEPNDCQSL 1487

  Fly   965 --WFNRIRIGVVIIAMHVQQPEL--VIRYAQQILVNSKTQDPTYSQAIVYMAWSLVSCQEADSLR 1025
              :.|::.:          |.|.  |:|||::..:|.:.:...|.:                   
 Worm  1488 ITYANKLNV----------QEEAAGVVRYAERNEMNFQMRGRWYEK------------------- 1523

  Fly  1026 GLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQSELEPHTRQFVVSQMMQCLQ 1090
             |..|.:.          ..|.:...|::|:....:....:..|.:..|..|.:......|:||:
 Worm  1524 -LNEWEKA----------LGAYELEEKKKSSCPNLQVYDEKDHLMTPEEAATAEEARMHEMRCLE 1577

  Fly  1091 DLGQWSQL-------------------VELKQQQMTRPEDRELNPFLQRSNVEVNALERL----- 1131
            .||:|.:|                   .|:.::|:    |.::.....|....|:..||:     
 Worm  1578 ALGRWDELNSKSVVWADQRGNRNDSVRDEINKKQL----DHKMAVIAARGAWAVDNWERMADYVS 1638

  Fly  1132 -LAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGL-------------------SERASFSS 1176
             ::::.:..:.:.|:..|..         ||:..:.||                   .|||....
 Worm  1639 VISENTQDGAMLRAVVAVHN---------DENTKAMGLIEKVREMIDSELTAMANESYERAYIPM 1694

  Fly  1177 IHMRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGGQE 1241
            :.::|..|   |.:.:|.:..|::...:. ..|...|.....:....:.|.:||.:   |...||
 Worm  1695 VSVQQMAE---LEEAIEYKTRPERRPRIA-LLWSRRLQGCRRNVEQWQRLIMLRGL---VLSPQE 1752

  Fly  1242 LSLLPVS-SGRCQNRSKFISSAILMRCLAWTQLLRQHCAPGSWETLCLDAAAAAREEGNLQLAET 1305
            :..|.|. |..|:.:.|...|..::|                 |.|.|.|        |..|...
 Worm  1753 MHPLRVKFSSMCRKQGKNSMSRAVLR-----------------ELLSLPA--------NSDLVRA 1792

  Fly  1306 LLTQFFGQPIGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSIDVCAAL 1370
            ...  |.:|:..:|....|.|....|  |.:|...:|.           .|.....:.|......
 Worm  1793 KAP--FDKPLLVLALAKQLYQDDHKD--EAIRALEDLA-----------NHWNKRINPIPKATGR 1842

  Fly  1371 CLNIQKSNNQPA-AGADLLLNLADW--IAVRTCNGLTTNQSPVLIQLLDQLPECPLTCDSSQPLA 1432
            .| |..|..:|| ..|.:||.|.:|  :..:|.|.:...:...:.|   |:.....|.:|..|..
 Worm  1843 EL-IPPSTKEPARICAKVLLKLGEWTELKSKTSNNMQVGELSFVRQ---QVSPQYRTKESRTPET 1903

  Fly  1433 IPQAERMVARLVHSCLQQRPNYAEALIAYG-NWCYRWGKKVAD---SCCVLTQADATAIS----- 1488
            |             ..:...||.:....|. .|...|.|..:.   :.|.......|.||     
 Worm  1904 I-------------AFENTINYYQQATQYDPGWHKVWHKLASTHFYAVCRERPHPTTVISPPQQP 1955

  Fly  1489 -------------------QALDIPQPLESEKLDELLQAL---STEQPPANCVEVCPDAARARDD 1531
                               .|...|||.....:.|.|..:   ....|..:.|.:.|..|....:
 Worm  1956 QQPKKMHIPPVTRATSPPPPAQKSPQPAPFHSITEPLSVIIDYPVPPPLGSLVGLPPMPAYLSSN 2020

  Fly  1532 EAAKNRLRRLTFLADKTPEALDAILQIWRRAIANTYD---YYKDAA---RSYFQYLSFKSGSGPE 1590
            .:...:...::.|::.:|              :|:.:   |.|.||   |.:.:.|....||   
 Worm  2021 SSLPPQHHHVSPLSNDSP--------------SNSAENKLYLKHAAHAVRCFAKALMCSPGS--- 2068

  Fly  1591 KPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVKHASGLQE----VLEQGLHTTPIAPWKVIIPQ 1651
                          .::|      ||||::|...|.....:    .|.:.:...|:..|...|||
 Worm  2069 --------------RLED------TLRLMQLWFDHGDDKDQDVYFALTETIFDLPVTTWLEAIPQ 2113

  Fly  1652 LFSRLNHHEPYVRKS---VCDLLCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACC 1713
            |.:||:.  |..:||   |..:||.:|:.|||.||: |:..|:|.:....:..|           
 Worm  2114 LMARLDC--PDDQKSVQLVLRVLCEIARHRPQAVIY-ALTVASRSKDVHRSKNA----------- 2164

  Fly  1714 YGYLLGELSKQAPEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYV--SRVSALATDFRPDD 1776
             |.:|.::.:...:.|:...|:.:||.|..:||.|.|..:|......|.  :.|.|:        
 Worm  2165 -GTVLEKMMEYHSKLVREASLVTEELVRCAILWHEQWHDALDDASRVYFHDNNVQAM-------- 2220

  Fly  1777 HEGKNNRFNVWRPQLLADLEALVAVTSRPPETTYERSFRKRFDAPIRLTVDALRHRRYPEAWDK- 1840
                   |:..|.  :.||     :....|.|..|.||::.:.:      |.....||.:|::. 
 Worm  2221 -------FDALRN--MNDL-----MQKGAPTTMKEHSFQQTYSS------DLKEAGRYVQAFESS 2265

  Fly  1841 -----LKQLYHILQS--NMIRGSGSTLK---MQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIE 1895
                 |.|.:.|..|  ..:|...:||.   :..:||.|.....:.:.:||  .:.|....|.|:
 Worm  2266 GNVKDLNQAWEIYCSVFKKLRDQLATLNSLDLVYVSPNLVSAKDLELVVPG--TYDPSAPIVSIQ 2328

  Fly  1896 SVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNG 1960
            |..|.:.|:.:|.:|:|:...||||..|.||.||.||...|||:||...:.|.::|..|:.    
 Worm  2329 SFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLANNSET---- 2389

  Fly  1961 CYR---AHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVANVPRRFTDLF 2022
            |.|   ...||::.|...||||.||.....:..|.|:::::::::                    
 Worm  2390 CRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVKEYREKKAKI-------------------- 2434

  Fly  2023 YNKLSPLLAKHN--MQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRR 2085
                 ||..:|.  .::|.......:...||:.:.....|..:.|...||.::.::..|......
 Worm  2435 -----PLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTN 2494

  Fly  2086 FVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKGRTL-RIPEKVPFRLTQNLV 2149
            :.|.::.|||:||::||||||..|::::..:|.:||||:..|||..... :.||:||||||:.|:
 Worm  2495 YTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLI 2559

  Fly  2150 QAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFVYDPLVDW 2194
            .||.:||::|.:....|.|||::|..:|:||.:||||||||:::|
 Worm  2560 NAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINW 2604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 126/681 (19%)
Rapamycin_bind 1738..1845 CDD:285924 26/114 (23%)
PIKKc_SMG1 1894..2196 CDD:270714 102/307 (33%)
FATC 3189..3217 CDD:280430
let-363NP_491549.2 HEAT repeat 654..683 CDD:293787 9/38 (24%)
TEL1 683..2695 CDD:227365 476/2281 (21%)
HEAT repeat 693..722 CDD:293787 3/28 (11%)
HEAT repeat 731..764 CDD:293787 5/33 (15%)
HEAT repeat 774..805 CDD:293787 6/30 (20%)
HEAT repeat 819..854 CDD:293787 11/55 (20%)
DUF3385 854..1028 CDD:288698 33/177 (19%)
HEAT repeat 863..887 CDD:293787 8/23 (35%)
Extensin_2 1970..2032 CDD:252669 10/61 (16%)
Rapamycin_bind 2188..2286 CDD:285924 28/125 (22%)
PIKKc_TOR 2327..2606 CDD:270713 102/307 (33%)
FATC 2664..2695 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D26975at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11139
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.110

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