DRSC/TRiP Functional Genomics Resources

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Protein Alignment nonC and Sh3pxd2a

DIOPT Version :9

Sequence 1:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster
Sequence 2:NP_032044.2 Gene:Sh3pxd2a / 14218 MGIID:1298393 Length:1124 Species:Mus musculus


Alignment Length:602 Identity:112/602 - (18%)
Similarity:208/602 - (34%) Gaps:184/602 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   711 AACIQ--TVLDYGLER--LEKYPKLL-ILYRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGG 770
            |.|:|  ||:|....|  .:.|..:: :.:.|:..|.:.    ..::.:|.:..||.....:.||
Mouse     3 AYCVQDATVVDVEKRRSPSKHYVYIINVTWSDSTSQTIY----RRYSKFFDLQMQLLDKFPIEGG 63

  Fly   771 ESS--------MPG-----------MASRRVSVWQQ------RISQYSAVRDNVFRDFFDRVQKP 810
            :..        :||           :|.:|:....:      |:..:.:..|.||| ||:  .:|
Mouse    64 QKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFR-FFE--ARP 125

  Fly   811 EQDSLIHCLRELFVRSCQVAPQDERQMNLSQCTKRCQRLAIAWLQFEAARYCVDQRLRTTVGKPQ 875
            |                .|.|..|...:    :||......:|.:                 .|:
Mouse   126 E----------------DVNPPKEDYGS----SKRKSVWLSSWAE-----------------SPK 153

  Fly   876 ETFLG----FEAIIMRHARLLSGCAKEIERSALDDLSLEELLSMQSNLSLLLG-FLDALEKLIYN 935
            :...|    .|.:|:....::|...|:                ..|.|||..| .:|.:||    
Mouse   154 KDVTGADTNAEPMILEQYVVVSNYKKQ----------------ENSELSLQAGEVVDVIEK---- 198

  Fly   936 AAEGSAFALRPPEKQ---VAAFFRLNNPT-CQSWFNRIRIGVVIIAMHVQQPELVIRYAQQILVN 996
             .|...:.:...|:|   .|.:....|.| ..|..|..:.|.|..........|..|:....:||
Mouse   199 -NESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVN 262

  Fly   997 SKTQDPTYSQAIVYMAWSLVSCQEADSL---RGLRLWARGKSCKSYKWLKYAADQAAGKRESALA 1058
            .:     :|:...|:.....:.|..|.:   :|:.:....|:.:.:.:::|     .||...|.|
Mouse   263 RQ-----HSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRY-----LGKEGWAPA 317

  Fly  1059 GYRTILAEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQRSNV 1123
            .|.     |:.:.:|.  ||:..::..::.:.::.:.|.|:..|..     .|:|       :..
Mouse   318 SYL-----KKAKDDLP--TRKKNLAGPVEIIGNIMEISNLLNKKAS-----GDKE-------APA 363

  Fly  1124 EVNALERLLAKSEES----CSSMDALGGVFQQLSLWPSNWDESVSSSG------LSERASFSSIH 1178
            |....|..:.|.|.|    |::.:.     ..|:: |......::...      ..:||..||.:
Mouse   364 EGEGSEAPITKKEISLPILCNASNG-----SALAI-PERTTSKLAQGSPAVARIAPQRAQISSPN 422

  Fly  1179 MRQRTEDIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQ--------RSCKELTLLRHIVQG 1235
            :|.|.              |.:.::.|..|.......||.:.        :||        |..|
Mouse   423 LRTRP--------------PPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSC--------ISDG 465

  Fly  1236 VS--GGQELSLLPVSSG 1250
            :|  |||:..::..:||
Mouse   466 ISFRGGQKAEVIDKNSG 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 88/474 (19%)
Rapamycin_bind 1738..1845 CDD:285924
PIKKc_SMG1 1894..2196 CDD:270714
FATC 3189..3217 CDD:280430
Sh3pxd2aNP_032044.2 PX_FISH 6..124 CDD:132798 24/124 (19%)
SH3_Tks5_1 170..222 CDD:213007 14/72 (19%)
SH3_Tks5_2 269..322 CDD:213010 11/62 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..443 9/42 (21%)
SH3_Tks5_3 450..503 CDD:213012 10/41 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..672
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 692..830
SH3_Tks5_4 838..888 CDD:212952
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..952
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1020..1050
SH3_Tks5_5 1067..1123 CDD:212953
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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