DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and Pi4kb

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	NP_001280644.1	Gene:	Pi4kb / 107650	MGIID:	1334433	Length:	816	Species:	Mus musculus

Alignment Length:	752	Identity:	134/752 - (17%)
Similarity:	237/752 - (31%)	Gaps:	257/752 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1586 GSGPEKPEGEGVVSQRER--------LHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPI 1642
            |:|......:|...:|:.        |.:.:|.|...::.:..|......|:|..:...|.....
Mouse   105 GAGVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFYFRN 169

  Fly  1643 APWKVIIPQLFSRLNHHE--------PYV----RKSV-----CDLL---------------CRLA 1675
            ......:|||.:...|.:        ||:    |:|:     |.||               .|..
Mouse   170 EDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGT 234

  Fly  1676 KSRPQLVIFPAVVGANREQQDATAPPA----------TARPTTEDACCYGYLLGELSKQA--PEA 1728
            |.| :|::...:..|:|:::..|..||          |.:.:..||.....|...|.:.|  |:.
Mouse   235 KLR-KLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKV 298

  Fly  1729 VQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVS-------------------RVSALATDFRP 1774
            ...               ||....|...|.|::.|                   |::.|.|
Mouse   299 ENE---------------DEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPT---- 344

  Fly  1775 DDHEGKNNRF-------------NVWRPQLLAD--------LEALVAVT-SRPPETTYERSFR-K 1816
              .|.|..|.             .||.|....|        .:|:|..: .:.|...|..... :
Mouse   345 --KEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECE 407

  Fly  1817 RFD---APIRLTVDALRHRR----YPEAWDKLKQLYHILQSNMIRGSGSTL-------KMQSISP 1867
            .||   .|.|:..:.:|..|    .||..         :......||.||:       :..|:.
Mouse   408 NFDTTSVPARIPENRIRSTRSVENLPECG---------ITHEQRAGSFSTVPNYDNDDEAWSVD- 462

  Fly  1868 VLCGIGRMRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMED 1932
               .||.:::.:|  :.|....|.:...||:|.     |..:.|:..|..:...|
Mouse   463 ---DIGELQVELP--EVHTNSCDNISQFSVDSI-----TSQESKEPVFIAAGDIR---------- 507

  Fly  1933 LHLDERIMQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQ 1997
            ..|.|::                        ||..:.....|:.         ....||.:.||:
Mouse   508 RRLSEQL------------------------AHTPTAFKRDPED---------PSAVALKEPWQE 539

  Fly  1998 RRSQVAGNAGAGAVAN----------------------VPRRFTDLFYNKLSPLLAK-------- 2032
            :..::...:..|.:.|                      |.::...::..:..||..|
Mouse   540 KVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVIS 604

  Fly  2033 ----------HNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFV 2087
                      :.:.:...::|..:|:|...|.|....|....|:.:               |.||
Mouse   605 ADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQ---------------RNFV 654

  Fly  2088 RCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYN-VCFEKGRTLRIPEKVPFRLTQNLVQA 2151
            :..:...::.|::.:.|||..|:|:: ..|.|:|||:. :.....|.|.. |...|:||...|..
Mouse   655 QSCAGYCLVCYLLQVKDRHNGNILLD-AEGHIIHIDFGFILSSSPRNLGF-ETSAFKLTTEFVDV 717

  Fly  2152 MGITGIEGP----FRLGCEYVLKVMRKERETLLTLLE 2184
            ||  |:.|.    :::.....|...||..:.::.::|
Mouse   718 MG--GLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	28/155 (18%)
		PIKKc_SMG1	1894..2196	CDD:270714	58/336 (17%)
		FATC	3189..3217	CDD:280430
Pi4kb	NP_001280644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Interaction with ACBD3. /evidence=ECO:0000250\|UniProtKB:Q9UBF8	2..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..120		3/14 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..318		16/82 (20%)
		PI4Kc_III_beta	529..816	CDD:270712	46/243 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900