DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonC and Trrap

DIOPT Version :9

Sequence 1:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster
Sequence 2:	XP_006504844.1	Gene:	Trrap / 100683	MGIID:	2153272	Length:	3911	Species:	Mus musculus

Alignment Length:	2384	Identity:	415/2384 - (17%)
Similarity:	756/2384 - (31%)	Gaps:	837/2384 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 IFIVVSNTLVQFAASYAETFECHFT------------DVVDIVIGWQLEAGQPTDLKTHCAQVLE 320
            ::..|.:.|||...|..:  ...||            |:.::||.|:|:            ::.:
Mouse  1981 VYYPVRHHLVQHMVSAMQ--RLGFTPSVTIEQRRLAVDLSEVVIKWELQ------------RIKD 2031

  Fly   321 QLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVGAFVGAFNTLLKCLARMQIFVGMPTC 385
            |     ....|.......:.|..: :::.|...::|:.|..|..|...:.....|.|   .:|..
Mouse  2032 Q-----QPDSDMDPNSSGEGVNSV-SIKRGLSVDSAQEVKRFRAATGAISAVFGRSQ---SLPGA 2087

  Fly   386 ECIVKMAVD---------HLIKIMPTLHLNTEALVNINELI---CICLLNNFTGLDPILLEQVLL 438
            :.::...:|         .||::...::.||....:..|::   |:.||......|.....::.|
Mouse  2088 DSLLAKPIDKQHTDTVVNFLIRVACQVNDNTNTAGSPGEVLSRRCVNLLKTALRPDMWCKSELKL 2152

  Fly   439 DQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIFQSNPYMTKVRLRSPGETSYKLLLR 503
            ....:::...| |...|.|..:||                               |......||.
Mouse  2153 QWFDKLLMTVE-QPNQVNYGNICT-------------------------------GLEVLNFLLT 2185

  Fly   504 TCQETLLIRNVPLLQQAYKYLVDDIDACLEKLLITAPRSKARKASVLLVFHLSALAALAKQTSSI 568
            ..|.       |.:..::|.|...|.||:     |...:|..:|...|:..|.::......|||:
Mouse  2186 VLQS-------PAILSSFKPLQRGIAACM-----TCGNTKVLRAVHSLLSRLMSIFPTEPSTSSV 2238

  Fly   569 IG-------MYACKPSILELLLTNCRAHELKFWSKYPAAQQA-IFGLLVV---HCQANHNF---- 618
            ..       :||....::...|||        :.|..:|..: :||.|::   .|..|.::
Mouse  2239 ASKYEELECLYAAVGKVIYEGLTN--------YEKATSANPSQLFGTLMILKSACCNNPSYIDRL 2295

  Fly   619 -----RTNSSLLRD----QELSAENTSPTANSFASILRFLDSVLGQAHQLAPQNLRVLLQWIQML 674
                 |:...::|:    |..|....:..|.:...::..||.|   ..:||..::.:...:||.:
Mouse  2296 ISVFMRSLQKMVREHLNPQTASGSTEATAAGTSELVMLSLDLV---KTRLAVMSMEMRKNFIQTI 2357

  Fly   675 LRECREKIDLLMEQENFRGI-------CRNIAATASKLVPL--ESAACIQTVLDYGLERLEKYPK 730
            |....||..   :.:..|.:       .:|.:..|:...|.  |.:..:..::.| :|:  ::|:
Mouse  2358 LTSLIEKSP---DAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTY-IEK--RFPE 2416

  Fly   731 LLIL-----------YRDTALQQLQMLSTNYHAPYFQIYAQLPLHLTLTGGESSMPGMASRRVSV 784
            .|.|           |||.||...::  |....|.|           |:|...:.|
Mouse  2417 DLELNAQFLDLVNYVYRDEALSGSEL--TAKLEPAF-----------LSGLRCAQP--------- 2459

  Fly   785 WQQRISQYSAVRDNVFRDFFDRVQKPEQDSLIH------------------CLRELFV------- 824
                     .:|...|..|.:.:::...:.|::                  |:..|..
Mouse  2460 ---------LIRAKFFEVFDNSMKRRVYERLLYVTCSQNWEAMGSHFWIKQCIELLLAVCEKSTA 2515

  Fly   825 --RSCQVA--PQDERQMNLSQCTKRCQRLAIAWLQFEAAR----------YCVDQRL----RTTV 871
              .|||.|  |.....:||:....|.....:..::.|...          ..:|..|    :|:.
Mouse  2516 IGTSCQGAMLPSITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTST 2580

  Fly   872 GKPQETF---LG--FEAIIMRHARLLSGCAKEIERSALDDLS----------------------- 908
            .|.:|..   :|  ...:..||.:.|. ..:|::..||  ||
Mouse  2581 PKTKELSEKDIGNQLHMLTNRHDKFLD-TLREVKTGAL--LSAFVQLCHISTTLAEKTWVQLFPR 2642

  Fly   909 LEELLSMQSNLSL-----------------------LLGFLDALEKLIYNAAEGSAFALRPPEKQ 950
            |.::||.:...:|                       |..|::|:.:.:            ||...
Mouse  2643 LWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCV------------PPIPM 2695

  Fly   951 VAAFFRLNNPTCQSWFNRIRIGVVIIAMHVQ---------QPELVIRYAQQILVNSKTQDPTYSQ 1006
            .....:....|...||..     .::..|..         :|:....:.:|..:....|:...|.
Mouse  2696 RPCVLKYLGKTHNLWFRS-----TLMLEHQAFEKGLSLPIKPKQTTEFYEQESITPPQQEILDSL 2755

  Fly  1007 AIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTILAEKELQS 1071
            |.:|   ||:  ||.|...|  ||.  |.||..:.....|.:..|..|.|...|     ||.:..
Mouse  2756 AELY---SLL--QEEDMWAG--LWQ--KRCKFSETATAIAYEQHGFFEQAQESY-----EKAMDK 2806

  Fly  1072 ELEPHTR-----------QFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFL------Q 1119
            ..:.|.|           |......::|.::|.||..|.|..|.:      ..:||:|      :
Mouse  2807 AKKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALTEFGQSK------GHINPYLVLECAWR 2865

  Fly  1120 RSNVEVNALERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTE 1184
            .||  ..|::..|.:.|.||....|          |..|          ..|...:..|..::..
Mouse  2866 VSN--WTAMKEALVQVEVSCPKEMA----------WKVN----------MYRGYLAICHPEEQQL 2908

  Fly  1185 DIVLHKLLEDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGV-----SGGQEL-- 1242
            ..:      :|.| :.|.:|...:||                 .|.|:|..|     ...|::
Mouse  2909 SFI------ERLV-EMASSLAIREWR-----------------RLPHVVSHVHTPLLQAAQQIIE 2949

  Fly  1243 ---------SLLPVSSGR-------------CQNRSKFIS------SAILMRCLAWTQLLRQHCA 1279
                     .|.|.:.||             .:||...:|      |::.|    |    |||..
Mouse  2950 LQEAAQINAGLQPTNLGRNNSLHDMKTVVKTWRNRLPIVSDDLSHWSSVFM----W----RQHHY 3006

  Fly  1280 PG--SWE------------------------TLCLDAAAA--------AREEGNLQLAETLLTQF 1310
            .|  :|.                        .|.:.|:|:        ||::|.:.:|..:|::.
Mouse  3007 QGKPTWSGMHSSSIVTAYENSSHHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVALDILSRI 3071

  Fly  1311 FGQPIGEIAALF-SLEQ---------GVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSID 1365
            ...|...|...| .:.|         ||...| |.::|. |:::..:|:.     .:.::::...
Mouse  3072 HTIPTVPIVDCFQKIRQQVKCYLQLAGVMGKN-ECMQGL-EVIESTNLKY-----FTKEMTAEFY 3129

  Fly  1366 VCAALCL-NIQKSN--NQPAAGA----DLLLNL----ADWIAVRTCNGLTTNQSPVLIQLLDQLP 1419
            ....:.| .|.||.  |:..:.|    |:|:..    .|::           :|..:.:....|.
Mouse  3130 ALKGMFLAQINKSEEANKAFSAAVQMHDVLVKAWAMWGDYL-----------ESIFVKERQLHLG 3183

  Fly  1420 ECPLTCDSSQPLAIPQAERMVARLVHSCLQQRPNYAEALIAYGNWCYRWGKKVADSCCVLTQADA 1484
            ...:||                 .:|:|..|..:.:...:|...|...:            ..|.
Mouse  3184 VSAITC-----------------YLHACRHQNESKSRKYLAKVLWLLSF------------DDDK 3219

  Fly  1485 TAISQALDIPQPLESEKLDELLQALSTEQPPANCVEVCPDAARARDDEAAKNRLRRLTFLADKTP 1549
            ..::.|:|                       ..|:.|.|              ::.|.::    |
Mouse  3220 NTLADAVD-----------------------KYCIGVPP--------------IQWLAWI----P 3243

  Fly  1550 EALDAILQIWRRAIANTYDYYKDAARSYFQ---------YLS--------FKSGSGPEKPEGEGV 1597
            :.|..::....:.:.|...  :...|.|.|         ||:        :||.||.::|...|.
Mouse  3244 QLLTCLVGSEGKLLLNLIS--QQVGRVYPQAVYFPIRTLYLTLKIEQRERYKSDSGQQQPSSAGN 3306

  Fly  1598 VSQRERLHVDDSNLVTTTLRLLRLI-VKHASGLQEVLEQGLHTTPIAPWKVIIPQL-FSRLNHHE 1660
            .|.    ...|...:..|..:.|.. :.|       :::.||.|.::..:.|:.|: :.|.|.||
Mouse  3307 QSH----SASDPGPIRATAPMWRCSRIMH-------MQRELHPTLLSSLEGIVDQMVWFRENWHE 3360

  Fly  1661 PYVRKSVCDLLCRLAKSRPQLVIFPAVVGANREQQDATAPPATARPTTEDACCYGYLLGELSKQA 1725
            ..:|:    |...|||                                    ||     .::.:.
Mouse  3361 EVLRQ----LQQGLAK------------------------------------CY-----SVAFEK 3380

  Fly  1726 PEAVQHVKLMVKELRRVCLLWDEYWIHSLAHIYNTYVSRVSALATDFRPDDHEGKNNRFNVWRPQ 1790
            ..||...|:....|.         ::..|...:...:..||.::|.|.....|
Mouse  3381 SGAVSDAKITPHTLN---------FVKKLVSTFGVGLENVSNVSTMFSSAASE------------ 3424

  Fly  1791 LLADLEALVAVTSRPPETTYERSFRK---------RFDAPIRLTVDALRHRRYPEAWDKL----- 1841
                     ::..|...|..:..|:|         .|..|..:.:..|..:.  :.|.|:
Mouse  3425 ---------SLARRAQATAQDPVFQKLKGQFTTDFDFSVPGSMKLHNLISKL--KKWIKILEAKT 3478

  Fly  1842 KQL--YHILQ------SNMIRGSGSTLKMQSISPVLCGIGRMRISMPGLDAHGPDGDQVYIE--- 1895
            |||  :.:::      ||.   |..|.:               :.:|| :...|.....||:
Mouse  3479 KQLPKFFLIEEKCRFLSNF---SAQTAE---------------VEIPG-EFLMPKPTHYYIKIAR 3524

  Fly  1896 ---SVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHL-----DERIMQFLSISNAIMAC 1952
               .||   .|....|..:::...|.||:.|.:|.  |.|..|     :||::|.|.:.|..:..
Mouse  3525 FMPRVE---IVQKHNTAARRLHIRGHNGKIYPYLV--MNDACLTESRREERVLQLLRLLNPCLEK 3584

  Fly  1953 RSDAPGNGCYRAHHYSVIP----LGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAGAVAN 2013
            |.:..     :.|.:..:|    :.||..|:........:..:||       |.....|......
Mouse  3585 RKETT-----KRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYK-------QRCAKKGIEHDNP 3637

  Fly  2014 VPRRFTDLFYNKLSPLLAKHNMQVSD--PRRQW-----------------PISVLLQVLDEL-SQ 2058
            :.|     :|::|:.:.|: ..|.|.  |...|                 |..||..:|.|: |.
Mouse  3638 ISR-----YYDRLATVQAR-GTQASHQIPALGWEDFVQGCVERQEAAVLAPPQVLRDILKEVQSN 3696

  Fly  2059 ETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLI--NLGSGDIVH 2121
            ..|..:|.........||.::....:.|...::::....:|:.|...:.:.:.|  :.|..::.:
Mouse  3697 MVPRSMLKEWALHTFPNATDYWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAY 3761

  Fly  2122 IDYNVCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAF 2186
            ..:::....| .|.....||||||.|:.:.:...|:.||.......|.:...:....:..:|:..
Mouse  3762 FRFDINDATG-DLDANRPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGVLKTV 3825

  Fly  2187 VYDPLVDWTTNDDAQALRRSLNAKLQESADGGGAGGLGVGDLKYHKKDKN--------KGKPLDS 2243
            :.|.::.|                                    |||.:.        .|:|.:.
Mouse  3826 LRDEIIAW------------------------------------HKKTQEDTSSPLSAAGQPENM 3854

  Fly  2244 DVKRQPFLSKLGMLQKYWSTNKTEL--MPQLEEMEQEVGNLQAA 2285
            |.::     .:.::||..:...|.|  :.|.:..|.:|..|.||
Mouse  3855 DSQQ-----LVSLVQKAVTAIMTRLHNLAQFDGGESKVNTLVAA 3893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413	133/725 (18%)
		Rapamycin_bind	1738..1845	CDD:285924	19/122 (16%)
		PIKKc_SMG1	1894..2196	CDD:270714	67/338 (20%)
		FATC	3189..3217	CDD:280430
Trrap	XP_006504844.1	TEL1	<2552..3911	CDD:227365	295/1698 (17%)
		FAT	2868..3211	CDD:367004	73/431 (17%)
		PIKK_TRRAP	3522..3835	CDD:270707	66/372 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900