Protein Alignment Atx-1 and ATXN1

DIOPT Version :10

• Sequence 1: NP_572356.1
• Gene: Atx-1 / 31624
• FlyBaseID: FBgn0029907
• Length: 230
• Species: Drosophila melanogaster
• Sequence 2: NP_000323.2
• Gene: ATXN1 / 6310
• HGNCID: 10548
• Length: 815
• Species: Homo sapiens
• Alignment Length: 154
• Identity: 59/154 - (38%)
• Similarity: 89/154 - (57%)
• Gaps: 26/154 - (16%)

  Fly    20 PPSLPPPSQQHWSSNGFSDDSASCFRRGSYIELASGAMRRVEDIRTEDFIQSALRSQLFELREAT 84
            ||:|||                 .|.:||.|:||:|.:::|||::||||||||..|...::..:|
Human   567 PPTLPP-----------------YFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSST 614

  Fly    85 VVRIDWSGCPSLVTLTFSYDTHHAKMDLQVQPGHPMFVYGQGWASCDPQLSLQLYELKCQQLQVG 149
            |.||:.|..|.:..:.|:...|.|::.::|...:|.||:||||:||.|:.:.||::|.|.:|.||
Human   615 VERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVG 679

  Fly   150 DICLSL---------VPNEQPAAP 164
            |:|:||         |...||..|
Human   680 DVCISLTLKNLKNGSVKKGQPVDP 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atx-1	NP_572356.1	AXH	43..158	CDD:197779	51/123 (41%)
ATXN1	NP_000323.2	ATXN-1_C	1..558	CDD:463627
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	185..270
		polyglutamine repeat	197..225
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	329..355
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..424
		Self-association. /evidence=ECO:0000269|PubMed:9097953	494..604		23/53 (43%)
		Interaction with USP7. /evidence=ECO:0000269|PubMed:12093161	538..815		59/154 (38%)
		RNA-binding. /evidence=ECO:0000269|PubMed:11136710	540..766		59/154 (38%)
		AXH	573..688	CDD:197779	50/114 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	762..798
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P54254	794..797