DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atx-1 and ATXN1L

DIOPT Version :9

Sequence 1:	NP_572356.1	Gene:	Atx-1 / 31624	FlyBaseID:	FBgn0029907	Length:	230	Species:	Drosophila melanogaster
Sequence 2:	NP_001131147.1	Gene:	ATXN1L / 342371	HGNCID:	33279	Length:	689	Species:	Homo sapiens

Alignment Length:	219	Identity:	77/219 - (35%)
Similarity:	111/219 - (50%)	Gaps:	35/219 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PSLPPPSQQHWSSNGFSDDSASCFRRGSYIELASGAMRRVEDIRTEDFIQSALRSQLFELREATV 85
            |:.||.:..|..|:         |.:|:.|:||:|.::||||::|:||::||..|...::..:||
Human   455 PTPPPITSSHLPSH---------FMKGAIIQLATGELKRVEDLQTQDFVRSAEVSGGLKIDSSTV 510

  Fly    86 VRIDWSGCPSLVTLTFSYDTHHAKMDLQVQPGHPMFVYGQGWASCDPQLSLQLYELKCQQLQVGD 150
            |.|..|..|..|.|.|......:|:.::|.|.||.|||||||:||.|..:.||:.|.|.:|||||
Human   511 VDIQESQWPGFVMLHFVVGEQQSKVSIEVPPEHPFFVYGQGWSSCSPGRTTQLFSLPCHRLQVGD 575

  Fly   151 ICL-----SLVPNEQPAAPC--PPQPAPPPPCPPPSLPPSMEM--------PVPMGS-------P 193
            :|:     ||..|....|.|  |.|..||...|..::..|.|:        |...||       |
Human   576 VCISISLQSLNSNSVSQASCAPPSQLGPPRERPERTVLGSRELCDSEGKSQPAGEGSRVVEPSQP 640

  Fly   194 PTGSYGFLP---FKHPYEMYAQMA 214
            .:|:....|   |:. |.|..:.|
Human   641 ESGAQACWPAPSFQR-YSMQGEEA 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atx-1	NP_572356.1	AXH	43..158	CDD:197779	52/119 (44%)
ATXN1L	NP_001131147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		Interaction with NCOR2 and ATXN1. /evidence=ECO:0000269\|PubMed:16121196	20..197
		Self-association	20..197
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..223
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..297
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..405
		AXH	475..579	CDD:285689	48/103 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..647		6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144536
Domainoid	1	1.000	111	1.000	Domainoid score	I6242
eggNOG	1	0.900	-	-		E1_KOG4053
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002655
OrthoInspector	1	1.000	-	-		otm40942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3533
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.770