DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment xit and ALG8

DIOPT Version :9

Sequence 1:	NP_572355.1	Gene:	xit / 31623	FlyBaseID:	FBgn0029906	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_014710.1	Gene:	ALG8 / 854233	SGDID:	S000005593	Length:	577	Species:	Saccharomyces cerevisiae

Alignment Length:	547	Identity:	210/547 - (38%)
Similarity:	296/547 - (54%)	Gaps:	91/547 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FWHLVGIAT-GLKILLIPAYHSTDFEVHRNWLAITHSLPLNQWYVDATSEWTLDYPPFFAYFEWL 68
            ||    |:| .||:||||.|.||||:|||||||||:.||:::||.:.||:||||||||||||||.
Yeast    47 FW----ISTLFLKLLLIPDYFSTDFDVHRNWLAITNKLPISEWYYEHTSQWTLDYPPFFAYFEWF 107

  Fly    69 LSQ-VAKYV-DPRMLVVDNLNYESKATVYFQRLSVIVTDLVYVLGVRSCLGSLGLGRDTQQFFAA 131
            ||| |.|.| |...|.:..:......|:.||||:||.::::..:.::..:.:..|...:|.|..|
Yeast   108 LSQFVPKSVRDDGCLDIVEIGKFGLPTIVFQRLTVIFSEILLFVILQIYINTTKLSERSQSFVVA 172

  Fly   132 SMLLLLNVGLIFVDHIHFQYNGLLFGILLLSIGSLIRQRFLWSAFAFAVLLNFKHIFLYMAPAFG 196
            |. ::|:.|.:.:|||||||||.||.||:.||.:...:|::..|..:...:.|||||||:||.:.
Yeast   173 SS-IVLSPGFLIIDHIHFQYNGFLFAILIGSIVAAKNKRYILCAVLYTTAICFKHIFLYLAPCYF 236

  Fly   197 VYLLRFYCL----------EQASVVSAVGAVVKLLVVGLTPFAVSFGPFWQQLPQVLSRLFPFKR 251
            |:|||.|.|          :....:.....::||..|.:..|.:.|.||..|:||||||||||.|
Yeast   237 VFLLRAYVLNVNNFKFKSYKDFLFLIRWANLLKLATVVVGIFTICFLPFAHQMPQVLSRLFPFSR 301

  Fly   252 GLTHAYWAPNFWALYNAADKLAAGV------------------------------LKVQDGGAST 286
            |||||||||||||||:..||:...|                              |...:.|
Yeast   302 GLTHAYWAPNFWALYSFMDKILTTVMLKLPYVHTFATKFIKPPLIPQNIKEINERLAANNNG--- 363

  Fly   287 TSGLVQEVRHSVLPAITPPVTFALTALF-MLPILVKLFRSAKKQSPLVFLRAVVLCGCSSFVFGW 350
            :.||||:|...:||.|.|.:||.||..: :|.:|..||..:.|:    |:.::.|||.:||:|||
Yeast   364 SKGLVQDVFFVILPQIPPKLTFILTIFYQVLAVLPLLFDPSFKR----FVGSLTLCGLASFLFGW 424

  Fly   351 HVHEKAILMVLLPLCLLTLVNREDARYAYVLGIAGYFSLFPLLFDA-DLYIPRYSLYMSYVAMMY 414
            |||||||::|::|...|...:|.......::..|||.||:|||:.. |.:|.  :||.....::|
Yeast   425 HVHEKAIMLVIIPFTFLVGFDRRLLVPFMLVASAGYVSLYPLLYKGQDFFIK--TLYTYVWCIIY 487

  Fly   415 GQLYRIFPGFRG--------------FHTLEWLYMLGFMAIPLYEHLL-------SFLLHLDQRL 458
                  |..||.              ...|...|:...:.|.....:|       |||    |:.
Yeast   488 ------FAAFRKTTKISSSVERRIFFLDRLALTYIFSLLPIVTVLQILDEVKWRYSFL----QKF 542

  Fly   459 PFLPLLLTSVYSALGVL-YFFGAYYLY 484
            .||.|::.|||.:||:: .:|...:||
Yeast   543 EFLGLMIYSVYCSLGIISSWFALSWLY 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
xit	NP_572355.1	Alg6_Alg8	12..478	CDD:281190	204/532 (38%)
ALG8	NP_014710.1	Alg6_Alg8	52..562	CDD:397324	203/529 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343934
Domainoid	1	1.000	316	1.000	Domainoid score	I190
eggNOG	1	0.900	-	-		E1_KOG2576
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6931
Inparanoid	1	1.050	319	1.000	Inparanoid score	I456
Isobase	1	0.950	-	0.741681	Normalized mean entropy	S1324
OMA	1	1.010	-	-		QHG55587
OrthoFinder	1	1.000	-	-		FOG0004662
OrthoInspector	1	1.000	-	-		oto100177
orthoMCL	1	0.900	-	-		OOG6_103222
Panther	1	1.100	-	-	LDO	PTHR12413
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R45
SonicParanoid	1	1.000	-	-		X3274
TreeFam	1	0.960	-	-
	16	15.740