DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment xit and ALG8

DIOPT Version :9

Sequence 1:	NP_572355.1	Gene:	xit / 31623	FlyBaseID:	FBgn0029906	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_076984.2	Gene:	ALG8 / 79053	HGNCID:	23161	Length:	526	Species:	Homo sapiens

Alignment Length:	538	Identity:	259/538 - (48%)
Similarity:	334/538 - (62%)	Gaps:	56/538 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IATG--------------LKILLIPAYHSTDFEVHRNWLAITHSLPLNQWYVDATSEWTLDYPPF 61
            ||||              ||.||||.||||||||||||||||||||::|||.:||||||||||||
Human     6 IATGTGNWFSALALGVTLLKCLLIPTYHSTDFEVHRNWLAITHSLPISQWYYEATSEWTLDYPPF 70

  Fly    62 FAYFEWLLSQVAKYVDPRMLVVDNLNYESKATVYFQRLSVIVTDLVYVLGVR---SCLGSLGLGR 123
            ||:||::||.||||.|..||.|.||||.|..|:.|||.|||..|:::|..||   .|:....:|:
Human    71 FAWFEYILSHVAKYFDQEMLNVHNLNYSSSRTLLFQRFSVIFMDVLFVYAVRECCKCIDGKKVGK 135

  Fly   124 DTQQ--FFAASMLLLLNVGLIFVDHIHFQYNGLLFGILLLSIGSLIRQRFLWSAFAFAVLLNFKH 186
            :..:  .|..|:|||.|.||:.||||||||||.|||::||||..|.::|.:..||.|||||:|||
Human   136 ELTEKPKFILSVLLLWNFGLLIVDHIHFQYNGFLFGLMLLSIARLFQKRHMEGAFLFAVLLHFKH 200

  Fly   187 IFLYMAPAFGVYLLRFYCL----EQASVVSAVGAVVKLLVVGLTPF---AVSFGPF--WQQLPQV 242
            |:||:|||:||||||.||.    ...|:.....:.|:::.:||..|   |:|.|||  ..|||||
Human   201 IYLYVAPAYGVYLLRSYCFTANKPDGSIRWKSFSFVRVISLGLVVFLVSALSLGPFLALNQLPQV 265

  Fly   243 LSRLFPFKRGLTHAYWAPNFWALYNAADKLAAGV---LKVQDGG----ASTTSGLVQEVRHSVLP 300
            .||||||||||.||||||||||||||.||:.:.:   ||..|..    ||.||||||:.:|:|||
Human   266 FSRLFPFKRGLCHAYWAPNFWALYNALDKVLSVIGLKLKFLDPNNIPKASMTSGLVQQFQHTVLP 330

  Fly   301 AITPPVTFALTALFMLPILVKLFRSAKKQSPLVFLRAVVLCGCSSFVFGWHVHEKAILMVLLPLC 365
            ::||..|...|.:.:||.:..|:  .|.|.|..|||.:.||..|||:|||||||||||:.:||:.
Human   331 SVTPLATLICTLIAILPSIFCLW--FKPQGPRGFLRCLTLCALSSFMFGWHVHEKAILLAILPMS 393

  Fly   366 LLTLVNREDARYAYVLGIAGYFSLFPLLFDADLYIPRYSLYMSYVAMMYGQLYRIFPGFRG-FHT 429
            ||::....||....:|...|::|||||||.|.....:..|.:.:.......|..:|...:. |:.
Human   394 LLSVGKAGDASIFLILTTTGHYSLFPLLFTAPELPIKILLMLLFTIYSISSLKTLFRKEKPLFNW 458

  Fly   430 LEWLYMLGFMAIPLYEHLLSFLLHLDQ---RLPFLPLLLTSVYSALGVLYFFGAYYLYALGISWG 491
            :|..|:||..  || |....|:.....   :.||:||||||||.|:|:.|            :|.
Human   459 METFYLLGLG--PL-EVCCEFVFPFTSWKVKYPFIPLLLTSVYCAVGITY------------AWF 508

  Fly   492 KVPIASSTSAAAVKRKRK 509
            |:.::....:|..|.|::
Human   509 KLYVSVLIDSAIGKTKKQ 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
xit	NP_572355.1	Alg6_Alg8	12..478	CDD:281190	253/504 (50%)
ALG8	NP_076984.2	Alg6_Alg8	22..508	CDD:281190	250/502 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147606
Domainoid	1	1.000	445	1.000	Domainoid score	I533
eggNOG	1	0.900	-	-		E1_KOG2576
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6931
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1638
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55587
OrthoDB	1	1.010	-	-		D379099at33208
OrthoFinder	1	1.000	-	-		FOG0004662
OrthoInspector	1	1.000	-	-		oto91317
orthoMCL	1	0.900	-	-		OOG6_103222
Panther	1	1.100	-	-	LDO	PTHR12413
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3274
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770