DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment xit and alg8

DIOPT Version :9

Sequence 1:	NP_572355.1	Gene:	xit / 31623	FlyBaseID:	FBgn0029906	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001017647.1	Gene:	alg8 / 327601	ZFINID:	ZDB-GENE-030131-5812	Length:	524	Species:	Danio rerio

Alignment Length:	530	Identity:	270/530 - (50%)
Similarity:	340/530 - (64%)	Gaps:	42/530 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DLFWHLVGIATG---LKILLIPAYHSTDFEVHRNWLAITHSLPLNQWYVDATSEWTLDYPPFFAY 64
            |..| ...:|.|   ||.|||.|||||||||||||||:|||||::|||.:|||||||||||.||:
Zfish     8 DQSW-FFALALGVSFLKCLLINAYHSTDFEVHRNWLALTHSLPVSQWYYEATSEWTLDYPPLFAW 71

  Fly    65 FEWLLSQVAKYVDPRMLVVDNLNYESKATVYFQRLSVIVTDLVYVLGVRSCLGSL--GLGRDT-- 125
            ||:.||.:|::.|..||||:||||.|.|||.||||||||||.|....|:.|...|  ..|:|.
Zfish    72 FEYGLSHIARFFDKEMLVVENLNYASPATVLFQRLSVIVTDAVLFYAVKECCKCLREDKGKDLLG 136

  Fly   126 QQFFAASMLLLLNVGLIFVDHIHFQYNGLLFGILLLSIGSLIRQRFLWSAFAFAVLLNFKHIFLY 190
            :..|..::|||.|.||:.||||||||||.|||:|||||...::.|.|..|..|::|||.|||:||
Zfish   137 KPSFILTVLLLWNFGLLIVDHIHFQYNGFLFGVLLLSIARHLQNRHLEGALLFSILLNLKHIYLY 201

  Fly   191 MAPAFGVYLLRFYCLEQASVVSAVG----AVVKLLVVG---LTPFAVSFGPFWQ--QLPQVLSRL 246
            :|||:|::|||.:|..|::...::.    :|::|:.:|   |:.||||.|||..  |||||||||
Zfish   202 IAPAYGIFLLRCFCFTQSNPDGSLSWRSFSVLRLVALGTIVLSTFAVSIGPFLALGQLPQVLSRL 266

  Fly   247 FPFKRGLTHAYWAPNFWALYNAADKLAA--GV-LKVQDGG----ASTTSGLVQEVRHSVLPAITP 304
            |||||||.|||||||.|||||.|||..:  || .|:.|..    ||.|.|||||.:|||||:::|
Zfish   267 FPFKRGLCHAYWAPNIWALYNIADKALSILGVKFKLLDMNKLPKASMTGGLVQEFQHSVLPSVSP 331

  Fly   305 PVTFALTALFMLPILVKLFRSAKKQSPLVFLRAVVLCGCSSFVFGWHVHEKAILMVLLPLCLLTL 369
            ..|...|.|.:||.|.||:.  :......|||.:|:|...||:|||||||||||||:|||.||.:
Zfish   332 LATLICTLLSILPALFKLWH--RPNGTRGFLRCLVVCALGSFMFGWHVHEKAILMVILPLSLLAV 394

  Fly   370 VNREDARYAYVLGIAGYFSLFPLLFDADLYIPRYSLYMSYVAMMYGQLYRIF-PGFRGFHTLEWL 433
            .:|||||...:|.|.|::|||||||.......:..|.:.:.......|..:| .|....:.||.:
Zfish   395 ESREDARTFLILSITGHYSLFPLLFTTQELPIKLFLMLLFTIFSVTSLKMLFRKGGSLLNPLESM 459

  Fly   434 YMLGFMAIPLYEHLLSFLLHL---DQRLPFLPLLLTSVYSALGVLYFFGAYYLYALGISWGKVPI 495
            |:||.  ||| |.:..|:..|   .:..|||||:|||:|.||||.|.|...|:..|
Zfish   460 YLLGL--IPL-ELVCEFIYPLTVWQKTFPFLPLMLTSLYCALGVTYAFIRLYISML--------- 512

  Fly   496 ASSTSAAAVK 505
            .||.:|..||
Zfish   513 TSSDTAKKVK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
xit	NP_572355.1	Alg6_Alg8	12..478	CDD:281190	260/492 (53%)
alg8	NP_001017647.1	Alg6_Alg8	20..506	CDD:281190	259/490 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581408
Domainoid	1	1.000	456	1.000	Domainoid score	I478
eggNOG	1	0.900	-	-		E1_KOG2576
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6931
Inparanoid	1	1.050	457	1.000	Inparanoid score	I1558
OMA	1	1.010	-	-		QHG55587
OrthoDB	1	1.010	-	-		D379099at33208
OrthoFinder	1	1.000	-	-		FOG0004662
OrthoInspector	1	1.000	-	-		oto39362
orthoMCL	1	0.900	-	-		OOG6_103222
Panther	1	1.100	-	-	LDO	PTHR12413
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R45
SonicParanoid	1	1.000	-	-		X3274
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800