DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment xit and alg8

DIOPT Version :9

Sequence 1:	NP_572355.1	Gene:	xit / 31623	FlyBaseID:	FBgn0029906	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_594599.1	Gene:	alg8 / 2542143	PomBaseID:	SPAC17C9.07	Length:	501	Species:	Schizosaccharomyces pombe

Alignment Length:	498	Identity:	217/498 - (43%)
Similarity:	305/498 - (61%)	Gaps:	40/498 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ATGLKILLIPAYHSTDFEVHRNWLAITHSLPLNQWYVDATSEWTLDYPPFFAYFEWLLSQVAKY- 75
            :|.:|:.|.|:|.||||||||||||||||||:::||..:.|||||||||||||.|.:||.:|.:
pombe    14 STFVKVFLFPSYRSTDFEVHRNWLAITHSLPISEWYKSSISEWTLDYPPFFAYMECVLSWIAYFF 78

  Fly    76 -VDPRMLVVDNLNYESKATVYFQRLSVIVTDLVYVLGVRSCLGSLGLGRDTQQFFAASMLLLLNV 139
             .|..||...||||.|.:||.|||.||||.:||.:..:|..:.|..: :|.:.....::.:.|:.
pombe    79 GFDKAMLDPYNLNYVSPSTVVFQRGSVIVLELVLLFALREYVLSSNV-KDQRNALLTAIDIFLSP 142

  Fly   140 GLIFVDHIHFQYNGLLFGILLLSIG-SLIRQRFLWSAFAFAVLLNFKHIFLYMAPAFGVYLLRFY 203
            ||:.:|||||||||.|||:||.||. :...:..|.||..|:.|:.|||||||:|||:.|||||.|
pombe   143 GLLIIDHIHFQYNGFLFGLLLWSIVLAKPEKNMLLSAAIFSALICFKHIFLYVAPAYFVYLLRVY 207

  Fly   204 CL-----EQASVVSAVGAVVKLLVVGLTPFAVSFGP--FWQQLPQVLSRLFPFKRGLTHAYWAPN 261
            |.     .|...:..:|:.|      ::.|.::|||  :.:|:||:|||||||.|||.|||||||
pombe   208 CFTPNFRPQFLNILKLGSTV------ISIFLLAFGPWIYMKQIPQLLSRLFPFSRGLCHAYWAPN 266

  Fly   262 FWALYNAADKLAAGVL-----KVQDGGA--STTSGLVQEVRHSVLPAITPPVTFALTALFMLPIL 319
            |||||:..|::|..||     .:..|.:  :.|.|||.|...:|||.|.|.:||.:.....:.:|
pombe   267 FWALYSFVDRVAFAVLPRFGYALNQGTSINAPTRGLVGESSFAVLPNIPPALTFYICLGLQITVL 331

  Fly   320 VKLFRSAKKQSPLVFLRAVVLCGCSSFVFGWHVHEKAILMVLLPLCLLTLVNREDARYAYVLGIA 384
            :|||   .|.:..||:.||.|||..||:|||||||||||||:||..:|:|::|........|.::
pombe   332 IKLF---IKPTWRVFVGAVTLCGWISFLFGWHVHEKAILMVILPFSILSLIDRRYLEAFRPLAVS 393

  Fly   385 GYFSLFPLLFDADLYIPRYSLYMSYVAMMYG-------QLYRIFPGFRGFHTLEWLYMLGFMAIP 442
            ||.||.||||..:....:|....:::||:..       .:.|:|.    .:.:...|:.||:.:.
pombe   394 GYLSLLPLLFTLNEAPIKYLFTGAWIAMLLTFDKCAPVPVKRVFL----LNRVNIAYISGFVPLF 454

  Fly   443 LYEHLLSFLLHLDQRLPFLPLLLTSVYSALGVLY-FFGAYYLY 484
            :|...:..|: :..:..||||:|.|.|:|.|:.: |....:||
pombe   455 IYNCFIHKLV-MGDKFEFLPLMLLSTYAAWGIFWSFVSLLWLY 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
xit	NP_572355.1	Alg6_Alg8	12..478	CDD:281190	214/490 (44%)
alg8	NP_594599.1	Alg6_Alg8	14..490	CDD:281190	214/490 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	364	1.000	Domainoid score	I149
eggNOG	1	0.900	-	-		E1_KOG2576
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6931
Inparanoid	1	1.050	364	1.000	Inparanoid score	I451
OMA	1	1.010	-	-		QHG55587
OrthoFinder	1	1.000	-	-		FOG0004662
OrthoInspector	1	1.000	-	-		oto101934
orthoMCL	1	0.900	-	-		OOG6_103222
Panther	1	1.100	-	-	LDO	PTHR12413
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R45
SonicParanoid	1	1.000	-	-		X3274
TreeFam	1	0.960	-	-
	14	13.860