DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment xit and algn-8

DIOPT Version :9

Sequence 1:	NP_572355.1	Gene:	xit / 31623	FlyBaseID:	FBgn0029906	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001021940.2	Gene:	algn-8 / 174542	WormBaseID:	WBGene00007464	Length:	766	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	199/519 - (38%)
Similarity:	268/519 - (51%)	Gaps:	46/519 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVGIATGLKILLIPAYHSTDFEVHRNWLAITHSLPLNQWYVDATSEWTLDYPPFFAYFEWLLSQV 72
            :..|....|.||||||.||||||||||:|:|...||.:||.:|||||||||||||||||..|:.|
Worm    10 VTAILISFKCLLIPAYVSTDFEVHRNWMAVTWQRPLCEWYTEATSEWTLDYPPFFAYFELGLASV 74

  Fly    73 AKYVD-PRMLVVDNLNYESKATVYFQRLSVIVTDLVYV-----LGVRSCLGSLGLGRDTQQ--FF 129
            |.:.. ...||:......|:..:.|||.|||..|::|:     ...||......:.:..||  ..
Worm    75 AHFFGFDECLVISKTPRFSRRILIFQRFSVIFCDILYIAVCALYSFRSPRLVSRIPKKLQQNGRE 139

  Fly   130 AASMLLLLNVGLIFVDHIHFQYNGLLFGILLLSIGSLIRQRFLWSAFAFAVLLNFKHIFLYMAPA 194
            |..:||.....||..|.||||||.:|..|.|:|:..:..:|:|.:|.::::|||||||::|.|..
Worm   140 ACFVLLASLQALIICDSIHFQYNSMLTAIFLMSLFFIDTERYLMAALSYSILLNFKHIYVYYALG 204

  Fly   195 FGVYLLRFYCLEQASVVSA-VGAVVKLLVVGLTPFAVSFGPF-----WQQLPQVLSRLFPFKRGL 253
            :..|.|..|.....:|:.| ....:.|.:..|.||..|..||     .|.|..:.:||||..|||
Worm   205 YVFYYLVNYFQFSGNVLLANTPKAISLAIALLIPFCASIFPFIHASGVQGLQNIATRLFPVSRGL 269

  Fly   254 THAYWAPNFWALYNAADKL---AAGVLKVQDGGAST-TSGLVQEVRHSVLPAITPPVTFALTALF 314
            ||||||||||||||.||..   ...:||:....|.| |||||||..|||||.::|..|..|..:.
Worm   270 THAYWAPNFWALYNFADLCLYRVLSLLKIGKFDAPTYTSGLVQEYSHSVLPNVSPMGTLCLVVIS 334

  Fly   315 MLPILVKLFRSAKKQSPLVFLRAVVLCGCSSFVFGWHVHEKAILMVLLPLCLLTLVNREDARYAY 379
            .:.:|..|. ..:|.|....|.||....| .|.||:|||||||::|.:|:.:..:.|.:......
Worm   335 SMIVLTGLV-IRRKDSADFSLFAVFSAFC-FFYFGYHVHEKAIILVTVPMTVFAIKNPKYHSILI 397

  Fly   380 VLGIAGYFSLFPLLFDADLYIPRYSLYMSYVAMMYGQLYRI--------FPGFRGFHTLEWLYML 436
            .|.....||||||||.....:.:|::.:||..:....|.|:        .|   ..|...|| ::
Worm   398 HLTCIASFSLFPLLFTPFETLLKYAICVSYFFIQLVFLKRVTLMPLSDLIP---TRHVASWL-LM 458

  Fly   437 GFMAIPLYEHLLSFLLH---LDQRLPFLPLLLTSVYSALGVLYFFGAYYLYALG-----ISWGK 492
            |.:.:      .:..||   ...||||.||:..|:.:|:.:....||......|     |.|.|
Worm   459 GMVEV------YNTFLHKWLWTSRLPFAPLMAISILTAIELTGLIGALIWSTFGDGIFEIWWAK 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
xit	NP_572355.1	Alg6_Alg8	12..478	CDD:281190	192/494 (39%)
algn-8	NP_001021940.2	Alg6_Alg8	15..496	CDD:281190	192/492 (39%)
algn-8	NP_001021940.2	Endonuclease_V	513..753	CDD:143472	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159599
Domainoid	1	1.000	282	1.000	Domainoid score	I879
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I1727
Isobase	1	0.950	-	0.741681	Normalized mean entropy	S1324
OMA	1	1.010	-	-		QHG55587
OrthoDB	1	1.010	-	-		D379099at33208
OrthoFinder	1	1.000	-	-		FOG0004662
OrthoInspector	1	1.000	-	-		oto19811
orthoMCL	1	0.900	-	-		OOG6_103222
Panther	1	1.100	-	-	LDO	PTHR12413
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R45
SonicParanoid	1	1.000	-	-		X3274
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890