Protein Alignment Tfeb and Mitf

DIOPT Version :10

• Sequence 1: XP_063123157.1
• Gene: Tfeb / 316214
• RGDID: 1309583
• Length: 485
• Species: Rattus norvegicus
• Sequence 2: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 160/540 - (29%)
• Similarity: 225/540 - (41%)
• Gaps: 164/540 - (30%)

  Rat     7 TAAMASRIGLRMQLMREQAQQEEQRERMQQQAV-------MHYM--------------------- 43
            ||...||..|::||.|||.||    ..:|||.:       ||.:
  Fly   173 TATPTSRTQLKLQLQREQQQQ----MMIQQQTLDTAMDPKMHLLFGSGQGLMESEFIDSGSTSAC 233

  Rat    44 --------QQQQQQQQQQLGGPPTPAINTPVHFQS-PPPVPGEVLKVQSYLENPTSYHLQQSQHQ 99
                    |..|..|...|....:.| ...|..|| ...||.:||:|.:.|||||.||:.|.|..
  Fly   234 GSGSSSLEQMSQLVQMDNLIDSSSGA-KLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKN 297

  Rat   100 KVREYLSETY---------------------------------------GNKF-------AAHVS 118
            :||:||||::                                       .|:|       |..:.
  Fly   298 QVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIM 362

  Rat   119 PAQGSPKPPPAASPGVRAGHVLSTSAGNSAPNSPMAMLHISSNPEKEFDDVIDNIMRLDSVLGYI 183
            |:..:....|.....||...:.........|||     |.:..||.........:.:.:|.|...
  Fly   363 PSDDAMPISPFGGSFVRCDDINPIEPTVLRPNS-----HGAGEPENAHRTAQLGLSKANSSLSST 422

  Rat   184 NPEMQMPNTLPLSSSHLNVYSGDPQVTASLVGV-TSSSCPAD--------------------LTQ 227
            .....:.|::.:||:..::.|....::.|:..| ||.|.|.|                    |:.
  Fly   423 RSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSI 487

  Rat   228 KRE---LTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDL------DVRWNK 283
            |:|   |||||..||||:||||||||:|||||||||||||||||.|:||.:|.      |:|.||
  Fly   488 KQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNK 552

  Rat   284 GTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGL----------- 337
            |||||:|||||:.::.::.:.|:.|...|::|:.|::|..||:||||||:.||:
  Fly   553 GTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSENHLTSLS 617

  Rat   338 -------------PTTSPSGVNMAELAQQVVKQELPSEDNPGETLMLGS----------EVPDPE 379
                         ||.|.|   ...|..|.|::::...|.....:.:..          .|...:
  Fly   618 APTQPYLKSFSLSPTASRS---RRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMEDCKYAVQGGD 679

  Rat   380 PMPALPPQAPLPSAAQPQSP 399
            ||  |...:.:.||  ||||
  Fly   680 PM--LSSHSHMQSA--PQSP 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tfeb	XP_063123157.1	None
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	20/38 (53%)
		bHLHzip_MITF_like	504..577	CDD:381403	45/72 (63%)