DRSC/TRiP Functional Genomics Resources

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Protein Alignment iav and TRPV1

DIOPT Version :10

Sequence 1:NP_572353.1 Gene:iav / 31621 FlyBaseID:FBgn0086693 Length:1123 Species:Drosophila melanogaster
Sequence 2:NP_061197.4 Gene:TRPV1 / 7442 HGNCID:12716 Length:839 Species:Homo sapiens


Alignment Length:805 Identity:193/805 - (23%)
Similarity:322/805 - (40%) Gaps:185/805 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 VISQSSATACKCLLYKLADYKRGGDLIDAINSGGLIAVEQLIREQFGVFMYNDGKGQVINRAEFL 89
            ::||.|..|......:|.|.:   .:.:|:.......:|.|:     :|:....|....|     
Human    96 LLSQDSVAASTEKTLRLYDRR---SIFEAVAQNNCQDLESLL-----LFLQKSKKHLTDN----- 147

  Fly    90 RWKYRD-HTEVTIPIEASLSIHD------PLGKWEDHKACWQMQYRGALGESLLHVLIICDSKVH 147
              :::| .|..|..::|.|::||      ||                     ||.:....||   
Human   148 --EFKDPETGKTCLLKAMLNLHDGQNTTIPL---------------------LLEIARQTDS--- 186

  Fly   148 TKLARVLLRVFPNLALDVMEGEEYLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRD 212
                   |:...|.:   .....|.|.:|||::|...|..||..|:|.|||:...|.|.||    
Human   187 -------LKELVNAS---YTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFF---- 237

  Fly   213 QQRANPAKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCG---SDPDAQDSFGNMILH-MVVV 273
                   |.|......|.||.||:.|||.....:...|:...   :|..|:||.||.:|| :|.|
Human   238 -------KKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEV 295

  Fly   274 CD--------------KLDMFGYALRHPKTPAKNGIVNQTGLTPLTLACKLGRAEVF-----REM 319
            .|              ::.|.|..| || |.....:.|:.|:|||.||...|:..|.     ||:
Human   296 ADNTADNTKFVTSMYNEILMLGAKL-HP-TLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREI 358

  Fly   320 LELSAREF------WRYSNITCSGYPLNALDTLLPDGRTNWNSALFIIL--NGTKPEHLDMLDGG 376
            .|...|..      |.|..:..|.|.|:.:||      ...||.|.:|.  :...|...|||...
Human   359 QEPECRHLSRKFTEWAYGPVHSSLYDLSCIDT------CEKNSVLEVIAYSSSETPNRHDMLLVE 417

  Fly   377 IIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQ 441
            .:.|||::||..|.:..|....|:...:::..:::.|.||. ||                |...:
Human   418 PLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV-DG----------------LPPFK 465

  Fly   442 SDEGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKNQGLSAFLKQ-------LSHAPA 499
            .::    .|||     .|...|..:::|.: |..|        :|:..||::       ...:.:
Human   466 MEK----TGDY-----FRVTGEILSVLGGV-YFFF--------RGIQYFLQRRPSMKTLFVDSYS 512

  Fly   500 KAIFLFSNLLILACIPFRLIGDTDTEE--AILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMIT 562
            :.:|...:|.:||.:   ::..:..:|  |.::|::...|..::::....:..|.:..||..||.
Human   513 EMLFFLQSLFMLATV---VLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMIL 574

  Fly   563 GDMFTFGIIYCIVLCGFSQAFYFL-----------------YKGHPQVQ--STMFNTYTSTWMAL 608
            .|:..|..:|.:.|.|||.|...|                 ::| |..:  .:.:|:..||.:.|
Human   575 RDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRG-PACRPPDSSYNSLYSTCLEL 638

  Fly   609 FQTTLGDYNYPDLNQTTYPNLSKTVFVI----FMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWM 669
            |:.|:|   ..||..|...:. |.||:|    ::|...|||||||||:||.|...:.::|:..|.
Human   639 FKFTIG---MGDLEFTENYDF-KAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWK 699

  Fly   670 KQWAKIVVTLERAVPQADAKGYLEAYSIPLGPSDDSGFEVRGVMVIKSKSKTRAKQRKGAVS--- 731
            .|.|..::..|::..:...|.:.....:.:|.:.|...:.|....:...:.|......|.::   
Human   700 LQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDP 764

  Fly   732 -NWKRVGRVTLTALKKRGMTGEEMR 755
             |.:.|.|....:|:...::|...:
Human   765 GNCEGVKRTLSFSLRSSRVSGRHWK 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
iavNP_572353.1 TRPV 126..757 CDD:454755 172/697 (25%)
ANK repeat 132..164 CDD:293786 6/31 (19%)
ANK repeat 173..203 CDD:293786 13/29 (45%)
ANK repeat 230..261 CDD:293786 10/33 (30%)
ANK repeat 299..329 CDD:293786 12/40 (30%)
TRPV1NP_061197.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
TRPV1 109..761 CDD:411980 184/762 (24%)
ANK 1. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA 111..139 6/35 (17%)
ANK 2. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA 154..186 10/52 (19%)
ANK repeat 155..197 CDD:293786 13/75 (17%)
ANK repeat 202..232 CDD:293786 13/29 (45%)
ANK 3. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA 204..229 12/24 (50%)
ANK repeat 248..282 CDD:293786 10/33 (30%)
ANK 4. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA 250..277 7/26 (27%)
ANK repeat 284..321 CDD:293786 10/37 (27%)
ANK 5. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA 286..322 9/36 (25%)
ANK 6. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA 336..359 9/22 (41%)
ANK 7. /evidence=ECO:0000269|PubMed:37117175, ECO:0007744|PDB:8GF8, ECO:0007744|PDB:8GF9, ECO:0007744|PDB:8GFA 394..416 8/21 (38%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:O35433 644..647 1/5 (20%)
AD. /evidence=ECO:0000250|UniProtKB:O35433 685..713 6/27 (22%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:O35433 768..802 4/22 (18%)
Required for PIP2-mediated channel inhibition. /evidence=ECO:0000250|UniProtKB:O35433 778..793 2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

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