DRSC/TRiP Functional Genomics Resources

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Protein Alignment iav and Trpv4

DIOPT Version :9

Sequence 1:NP_572353.1 Gene:iav / 31621 FlyBaseID:FBgn0086693 Length:1123 Species:Drosophila melanogaster
Sequence 2:NP_076460.1 Gene:Trpv4 / 66026 RGDID:69337 Length:871 Species:Rattus norvegicus


Alignment Length:603 Identity:147/603 - (24%)
Similarity:253/603 - (41%) Gaps:138/603 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   171 YLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANPAKSTDYEGLAYMGEYPL 235
            |.|.:|||::|.......|..|:..|||:|.:|.|.||.|:|:           .|..|.||.||
  Rat   236 YRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDE-----------GGYFYFGELPL 289

  Fly   236 AWAACCANESVYNLLVD---CGSDPDAQDSFGNMILHMVVV----------------------CD 275
            :.|||.....:.|.|.:   ..:|...|||.||.:||.:|.                      |.
  Rat   290 SLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCS 354

  Fly   276 KLDMFGYALRHPKTPAKN--GIVNQTGLTPLTLACKLGRAEVFREMLELS---------AREF-- 327
            :|           .|..|  .::|..||:||.:|.|.|:..||:.::...         :|:|  
  Rat   355 RL-----------FPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKD 408

  Fly   328 WRYSNITCSGYPLNALDTLLPDGRTNWNSALFIILNGTKPEHL-DMLDGGIIQRLLEEKWKTFAQ 391
            |.|..:..|.|.|::|||...:     .|.|.|::..:|.|:. :||....|..||.:||:.|..
  Rat   409 WAYGPVYSSLYDLSSLDTCGEE-----VSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGA 468

  Fly   392 NQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQSDEGDSGGGDYNAQT 456
            ..|...::.....::..:::.|.:|.                             .|...|..:|
  Rat   469 VSFYINVVSYLCAMVIFTLTAYYQPL-----------------------------EGTPPYPYRT 504

  Fly   457 VARY---CAEFATLV-GVLSYVIFQQGDEIKNQGLSAFLKQLSHAPAKAI--------FLFSNLL 509
            ...|   ..|..||: |||.:.     ..||:    .|:|:.....:..:        |::|.|:
  Rat   505 TVDYLRLAGEVITLLTGVLFFF-----TSIKD----LFMKKCPGVNSLFVDGSFQLLYFIYSVLV 560

  Fly   510 ILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGDMFTFGIIYCI 574
            :::...:  :...:...|:::||:...|...::|...::|||.:..||..::..|:|.|.::|.:
  Rat   561 VVSAALY--LAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLL 623

  Fly   575 VLCGFSQAFYFLYK------------------GHPQVQSTMFNTYTSTWMALFQTTLGDYNYPDL 621
            .:.|::.|...|..                  .:|..:.:  .|:::..:.||:.|:|..:...|
  Rat   624 FMIGYASALVTLLNPCTNMKVCNEDQSNCTVPSYPACRDS--ETFSAFLLDLFKLTIGMGDLEML 686

  Fly   622 NQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQA 686
            :...||.:...:.|.::|...:||||||||:||.|...|.::|:..|..|||..::.:||:.|..
  Rat   687 SSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVF 751

  Fly   687 DAKGYLEAYSIPLGPSDD 704
            ..|.:.....:.:|.|.|
  Rat   752 LRKAFRSGEMVTVGKSSD 769

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
iavNP_572353.1 ANKYR <127..>202 CDD:223738 12/30 (40%)
ANK repeat 132..164 CDD:293786
ANK 173..315 CDD:238125 49/168 (29%)
ANK repeat 173..203 CDD:293786 11/29 (38%)
Ank_2 177..261 CDD:289560 27/86 (31%)
ANK repeat 230..261 CDD:293786 10/33 (30%)
Ank_2 235..324 CDD:289560 29/124 (23%)
ANK 258..414 CDD:238125 46/191 (24%)
ANK repeat 299..329 CDD:293786 11/40 (28%)
Ion_trans 501..665 CDD:278921 43/189 (23%)
Trpv4NP_076460.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68
TRPV4 103..834 CDD:411979 147/603 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..143
ANK repeat 191..231 CDD:293786
ANK repeat 237..268 CDD:293786 11/30 (37%)
ANK 1 237..266 10/28 (36%)
Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250|UniProtKB:A0A1D5PXA5 249..251 0/1 (0%)
ANK repeat 284..318 CDD:293786 10/33 (30%)
ANK 2 284..313 9/28 (32%)
Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250|UniProtKB:A0A1D5PXA5 296..299 0/2 (0%)
ANK 3 369..398 9/28 (32%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:O35433 679..682 1/2 (50%)
Interaction with calmodulin and ITPR3. /evidence=ECO:0000250|UniProtKB:Q9HBA0 812..831
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166338790
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3676
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D386733at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8914
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X396
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
87.710

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