DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment iav and Trpv6

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_071858.3	Gene:	Trpv6 / 64177	MGIID:	1927259	Length:	767	Species:	Mus musculus

Alignment Length:	757	Identity:	194/757 - (25%)
Similarity:	313/757 - (41%)	Gaps:	143/757 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 EFLRWKYRDHT-----------------EVTIPIEASLSIHDPLGKWEDHKACWQMQYRGALGES 134
            :|.||.:|..:                 |..:.:.|..:....|.|....:.| ::..|||:||:
Mouse    58 KFCRWFHRQESWAQSRDEQNLLQQKRIWESPLLLAAKENDVQALSKLLKFEGC-EVHQRGAMGET 121

  Fly   135 LLHVLIICDSKVHTKLARVLLRVFPNLALDVMEGEEYLGASALHLSIAYSNNELVADLIEAGADI 199
            .||:..:.|   :.:.|.||:...|.|..:.|..|.|.|.:|||:::...|..||..|:..||.:
Mouse   122 ALHIAALYD---NLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASV 183

  Fly   200 HQRAIGSFFLPRDQQRANPAKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCGSDPDAQDSFG 264
            ..||.||.|..|.            ..|.|.||:||::|||..:|.:..||::.|:|..||||.|
Mouse   184 SARATGSVFHYRP------------HNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLG 236

  Fly   265 NMILHMVVV-------CDKLDMFGYALR-----HPKTPAKNGIVNQTGLTPLTLACKLGRAEVFR 317
            |.:||::::       |   .|:...|.     |.|  :...:.|..||||..||...|...:|:
Mouse   237 NTVLHILILQPNKTFAC---QMYNLLLSYDGGDHLK--SLELVPNNQGLTPFKLAGVEGNIVMFQ 296

  Fly   318 EMLELSAREFWRYSNITCSGYPLNALDTLLPDGRTNWNSALFIILNGTKPEHLDMLDGGIIQRLL 382
            .:::......|.|..:|.:.|.|..:|:...|     .|.|.:|:...|.|...:||...::.|:
Mouse   297 HLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDD-----QSLLELIVTTKKREARQILDQTPVKELV 356

  Fly   383 EEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLD----IQSD 443
            ..|||.:.:..|.....|...:::|.::....||.........:...:......||.    ...|
Mouse   357 SLKWKRYGRPYFCVLGAIYVLYIICFTMCCVYRPLKPRITNRTNPRDNTLMQQKLLQEAYVTPKD 421

  Fly   444 EGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKNQGLSAFLKQ-LSHAPAKAIFLFSN 507
            :             .|...|..::||.:..::.:..| |...|::.|..| :...|...|.:...
Mouse   422 D-------------LRLVGELVSIVGAVIILLVEIPD-IFRLGVTRFFGQTILGGPFHVIIITYA 472

  Fly   508 LLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGDMFTFGIIY 572
            .::|..:..||. :.|.|...:.||:...|..:|:||...::.|||..||..||.||:..|..:.
Mouse   473 FMVLVTMVMRLT-NVDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLM 536

  Fly   573 CIVLCGFSQAFYFLYKGHPQVQSTMFNTYTSTWMALFQT-----TL--GDYNYP-DLNQTTYPNL 629
            .:|:.||:.|||.:::.....:...|..|.   ||||.|     |:  |..||. ||     |.:
Mouse   537 AVVILGFASAFYIIFQTEDPDELGHFYDYP---MALFSTFELFLTIIDGPANYDVDL-----PFM 593

  Fly   630 SKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQA-------- 686
            ....:..|.|...:|:||:||||||:|:..|..:.::.|..|.....|.|||.:|:.
Mouse   594 YSVTYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLERKLPRCLWPRSGIC 658

  Fly   687 -----------------------DAKGYLEA-------YSIPLGPSDDSGFEVR------GVMVI 715
                                   ..:.|.:|       ||..|  ..|||.::.      ..:..
Mouse   659 GREYGLGDRWFLRVEDRQDLNRQRIRRYAQAFQQQDGLYSEDL--EKDSGEKLETARPFGAYLSF 721

  Fly   716 KSKSKTRAKQRKGAVSNWKRVG----RVTLTALKKRGMTGEE 753
            .:.|.:|:..|..  :||:|:.    |..|..:..||:...|
Mouse   722 PTPSVSRSTSRSS--TNWERLRQGALRKDLRGIINRGLEDGE 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	26/74 (35%)
		ANK repeat	132..164	CDD:293786	10/31 (32%)
		ANK	173..315	CDD:238125	51/153 (33%)
		ANK repeat	173..203	CDD:293786	10/29 (34%)
		Ank_2	177..261	CDD:289560	29/83 (35%)
		ANK repeat	230..261	CDD:293786	13/30 (43%)
		Ank_2	235..324	CDD:289560	31/100 (31%)
		ANK	258..414	CDD:238125	43/167 (26%)
		ANK repeat	299..329	CDD:293786	8/29 (28%)
		Ion_trans	501..665	CDD:278921	55/171 (32%)
Trpv6	NP_071858.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		trp	52..748	CDD:273311	190/742 (26%)
		ANK 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023, ECO:0000269\|PubMed:18232717	84..114		5/30 (17%)
		ANK repeat	86..116	CDD:293786	5/30 (17%)
		ANK repeat	118..150	CDD:293786	10/34 (29%)
		ANK 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023, ECO:0000269\|PubMed:18232717	118..147		10/31 (32%)
		ANK	119..242	CDD:238125	50/137 (36%)
		Interaction with calmodulin	133..143		3/9 (33%)
		ANK repeat	156..187	CDD:293786	10/30 (33%)
		ANK 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023, ECO:0000269\|PubMed:18232717	156..185		10/28 (36%)
		ANK repeat	202..233	CDD:293786	13/30 (43%)
		ANK 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023, ECO:0000269\|PubMed:18232717	202..231		12/28 (43%)
		ANK 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023, ECO:0000269\|PubMed:18232717	235..276		9/45 (20%)
		ANK repeat	235..265	CDD:293786	7/32 (22%)
		ANK 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023, ECO:0000269\|PubMed:18232717	278..307		8/28 (29%)
		Selectivity filter. /evidence=ECO:0000269\|PubMed:14736889	580..584		1/3 (33%)
		Interaction with S100A10. /evidence=ECO:0000250	637..641		0/3 (0%)
		Interaction with calmodulin	689..707		6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835187
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3510
Isobase	1	0.950	-	0	Normalized mean entropy	S5793
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	1	1.000	-	-		mtm8679
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.710