DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and Trpv4

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_071300.2	Gene:	Trpv4 / 63873	MGIID:	1926945	Length:	871	Species:	Mus musculus

Alignment Length:	677	Identity:	158/677 - (23%)
Similarity:	279/677 - (41%)	Gaps:	143/677 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 YLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANPAKSTDYEGLAYMGEYPL 235
            |.|.::||::|.......|..|:..|||:|.:|.|.||.|:|:           .|..|.||.||
Mouse   236 YRGQTSLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDE-----------GGYFYFGELPL 289

  Fly   236 AWAACCANESVYNLLVD---CGSDPDAQDSFGNMILHMVVV----------------------CD 275
            :.|||.....:.|.|.:   ..:|...|||.||.:||.:|.                      |.
Mouse   290 SLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCS 354

  Fly   276 KLDMFGYALRHPKTPAKN--GIVNQTGLTPLTLACKLGRAEVFREMLELS---------AREF-- 327
            :|           .|..|  .::|..||:||.:|.|.|:..||:.::...         :|:|
Mouse   355 RL-----------FPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKD 408

  Fly   328 WRYSNITCSGYPLNALDTLLPDGRTNWNSALFIILNGTKPEHL-DMLDGGIIQRLLEEKWKTFAQ 391
            |.|..:..|.|.|::|||...:     .|.|.|::..:|.|:. :||....|..||.:||:.|..
Mouse   409 WAYGPVYSSLYDLSSLDTCGEE-----VSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGA 468

  Fly   392 NQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQSDEGDSGGGDYNAQT 456
            ..|...::.....::..:::.|.:|.                             .|...|..:|
Mouse   469 VSFYINVVSYLCAMVIFTLTAYYQPL-----------------------------EGTPPYPYRT 504

  Fly   457 VARY---CAEFATL-VGVLSYV-----IFQQGDEIKNQGLSAFLK----QLSHAPAKAIFLFSNL 508
            ...|   ..|..|| .|||.:.     :|.:    |..|:::...    ||.:      |::|.|
Mouse   505 TVDYLRLAGEVITLFTGVLFFFTSIKDLFTK----KCPGVNSLFVDGSFQLLY------FIYSVL 559

  Fly   509 LILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGDMFTFGIIYC 573
            ::::...:  :...:...|:::||:...|...::|...::|||.:..||..::..|:|.|.::|.
Mouse   560 VVVSAALY--LAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYL 622

  Fly   574 IVLCGFSQAFYFLYK------------------GHPQVQSTMFNTYTSTWMALFQTTLGDYNYPD 620
            :.:.|::.|...|..                  .:|..:.:  .|:::..:.||:.|:|..:...
Mouse   623 LFMIGYASALVTLLNPCTNMKVCDEDQSNCTVPTYPACRDS--ETFSAFLLDLFKLTIGMGDLEM 685

  Fly   621 LNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQ 685
            |:...||.:...:.|.::|...:||||||||:||.|...|.::|:..|..|||..::.:||:.|.
Mouse   686 LSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPV 750

  Fly   686 ADAKGYLEAYSIPLGPSDDSGFEVRGVMVIKSKSKTRAKQRKGAVSNWKRVGRVTLTALKKRGMT 750
            ...|.:.....:.:|.|.|...:.|....:...:.:...|..|.::  :..|:..:........|
Mouse   751 FLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIIN--EDPGKSEIYQYYGFSHT 813

  Fly   751 GEEMRRLMWGRASISSPVKVTKQKLKD 777
            ...:||..|. :.:...|::.|....|
Mouse   814 VGRLRRDRWS-SVVPRVVELNKNSSAD 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	11/30 (37%)
		ANK repeat	132..164	CDD:293786
		ANK	173..315	CDD:238125	48/168 (29%)
		ANK repeat	173..203	CDD:293786	10/29 (34%)
		Ank_2	177..261	CDD:289560	27/86 (31%)
		ANK repeat	230..261	CDD:293786	10/33 (30%)
		Ank_2	235..324	CDD:289560	29/124 (23%)
		ANK	258..414	CDD:238125	46/191 (24%)
		ANK repeat	299..329	CDD:293786	11/40 (28%)
		Ion_trans	501..665	CDD:278921	43/181 (24%)
Trpv4	NP_071300.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..143
		trp	149..803	CDD:273311	151/638 (24%)
		ANK repeat	191..231	CDD:293786
		ANK repeat	237..268	CDD:293786	10/30 (33%)
		ANK 1	237..266		9/28 (32%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:A0A1D5PXA5	249..251		0/1 (0%)
		ANK repeat	284..318	CDD:293786	10/33 (30%)
		ANK 2	284..313		9/28 (32%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:A0A1D5PXA5	296..299		0/2 (0%)
		ANK 3	369..398		9/28 (32%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:12093812	679..682		1/2 (50%)
		Interaction with calmodulin and ITPR3. /evidence=ECO:0000250\|UniProtKB:Q9HBA0	812..831		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835189
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8679
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.700