DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and TRPV4

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_011536932.2	Gene:	TRPV4 / 59341	HGNCID:	18083	Length:	922	Species:	Homo sapiens

Alignment Length:	590	Identity:	153/590 - (25%)
Similarity:	255/590 - (43%)	Gaps:	112/590 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 YLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANPAKSTDYEGLAYMGEYPL 235
            |.|.:|||::|.......|..|:..|||:|.:|.|.||.|:|:           .|..|.||.||
Human   287 YRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDE-----------GGYFYFGELPL 340

  Fly   236 AWAACCANESVYNLLVD---CGSDPDAQDSFGNMILH-MVVVCD------KLDMFGYALRHPKT- 289
            :.|||.....:.|.|.:   ..:|...|||.||.:|| :|.:.|      |.....|.|...|.
Human   341 SLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCA 405

  Fly   290 ---PAKN--GIVNQTGLTPLTLACKLGRAEVFREMLELS---------AREF--WRYSNITCSGY 338
               |..|  .::|..||:||.:|.|.|:..:|:.::...         :|:|  |.|..:..|.|
Human   406 RLFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLY 470

  Fly   339 PLNALDTLLPDGRTNWNSALFIILNGTKPEHL-DMLDGGIIQRLLEEKWKTFAQNQFLKRLLILS 402
            .|::|||...:.     |.|.|::..:|.|:. :||....|..||.:||:.|....|...::...
Human   471 DLSSLDTCGEEA-----SVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYL 530

  Fly   403 THLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQSDEGDSGGGDYNAQTVARY---CAEF 464
            ..::..:::.|.:|.                             .|...|..:|...|   ..|.
Human   531 CAMVIFTLTAYYQPL-----------------------------EGTPPYPYRTTVDYLRLAGEV 566

  Fly   465 ATL-VGVLSYVIFQQGDEIKNQGLSAFLKQLSHAPAKAI--------FLFSNLLILACIPFRLIG 520
            .|| .|||.:.     ..||:    .|:|:.....:..|        |::|.|:|::...:  :.
Human   567 ITLFTGVLFFF-----TNIKD----LFMKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALY--LA 620

  Fly   521 DTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYF 585
            ..:...|:::||:...|...::|...::|||.:..||..::..|:|.|.::|.:.:.|::.|...
Human   621 GIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVS 685

  Fly   586 LYK--------GHPQVQSTM--------FNTYTSTWMALFQTTLGDYNYPDLNQTTYPNLSKTVF 634
            |..        ...|...|:        ..|:::..:.||:.|:|..:...|:.|.||.:...:.
Human   686 LLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILL 750

  Fly   635 VIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQADAKGYLEAYSIPL 699
            |.::|...:||||||||:||.|...|.::|:..|..|||..::.:||:.|....|.:.....:.:
Human   751 VTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTV 815

  Fly   700 GPSDD 704
            |.|.|
Human   816 GKSSD 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	12/30 (40%)
		ANK repeat	132..164	CDD:293786
		ANK	173..315	CDD:238125	52/157 (33%)
		ANK repeat	173..203	CDD:293786	11/29 (38%)
		Ank_2	177..261	CDD:289560	27/86 (31%)
		ANK repeat	230..261	CDD:293786	10/33 (30%)
		Ank_2	235..324	CDD:289560	31/113 (27%)
		ANK	258..414	CDD:238125	48/180 (27%)
		ANK repeat	299..329	CDD:293786	10/40 (25%)
		Ion_trans	501..665	CDD:278921	47/187 (25%)
TRPV4	XP_011536932.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8438
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850