DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and TRPV5

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_062815.3	Gene:	TRPV5 / 56302	HGNCID:	3145	Length:	729	Species:	Homo sapiens

Alignment Length:	691	Identity:	165/691 - (23%)
Similarity:	282/691 - (40%)	Gaps:	97/691 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 MQYRGALGESLLHVLIICDSKVHTKLARVLLRVFPNLALDVMEGEEYLGASALHLSIAYSNNELV 189
            ::.||||||:.||:..:.|   :.:.|.||:...|.|..:....|.:.|.:|||:::...|..||
Human    72 VRQRGALGETALHIAALYD---NLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLV 133

  Fly   190 ADLIEAGADIHQRAIGSFFLPRDQQRANPAKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCG 254
            ..|:...|.:..||.|:.|      |.:|      ..|.|.||:||::|||..:|.:..||::.|
Human   134 RALLTRRASVSARATGTAF------RHSP------RNLIYFGEHPLSFAACVNSEEIVRLLIEHG 186

  Fly   255 SDPDAQDSFGNMILHMVVV-------CDKLD-MFGYALRHPKTPAKNGIVNQTGLTPLTLACKLG 311
            :|..||||.||.:||::::       |...: :..|..........:.:.|..||||..||...|
Human   187 ADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEG 251

  Fly   312 RAEVFREMLELSAREFWRYSNITCSGYPLNALDTLLPDGRTNWN---SALFIILNGTKPEHLDML 373
            ...:|:.:::......|.|..:|...|.|..:|        :|.   |.|.::::..|.|...:|
Human   252 NTVMFQHLMQKRRHIQWTYGPLTSILYDLTEID--------SWGEELSFLELVVSSDKREARQIL 308

  Fly   374 DGGIIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALL 438
            :...::.|:..||..:.:..|.....:...:::|.:.....||..........|.........||
Human   309 EQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLL 373

  Fly   439 DIQSDEGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKNQGLSAFLKQLSHAPAKAIF 503
            ....:         ..:.:.|...|..::||.:..::.:..|..:......|.|.:...|...|.
Human   374 QEAYE---------TREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVII 429

  Fly   504 LFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGDMFTF 568
            :....|:|..:..||. :|:.|...:.||:...|..:|:|....::.|||..||..||.||:..|
Human   430 ITYASLVLVTMVMRLT-NTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRF 493

  Fly   569 GIIYCIVLCGFSQAFYFLYKGHPQVQSTMFNTYTSTWMALFQTTLGDYNYPDLNQTTYPNLSKTV 633
            ..:..:|:.||:.|||.:::.........|..|.......|:..|...:.|.......|.:...|
Human   494 CWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIV 558

  Fly   634 FVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQA--DAKG------ 690
            ...|.|...:|:||:.|||||:|:..|.::.::.|..|.....|.|||.:|:.  ...|
Human   559 NFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEF 623

  Fly   691 -----------------------YLEAY--------------SIPLGPSDDSGFEVRGVMVIKSK 718
                                   |:|.:              ..|.|.  :||...|..:.:.:.
Human   624 GLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGA--ESGTLARASLALPTS 686

  Fly   719 SKTRAKQRKGAVSNWKRVGRVTLTALKKRGMT-----GEEM 754
            |.:|...:..:...|:.:.:.||..| ..|:.     |||:
Human   687 SLSRTASQSSSHRGWEILRQNTLGHL-NLGLNLSEGDGEEV 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	24/74 (32%)
		ANK repeat	132..164	CDD:293786	10/31 (32%)
		ANK	173..315	CDD:238125	47/149 (32%)
		ANK repeat	173..203	CDD:293786	9/29 (31%)
		Ank_2	177..261	CDD:289560	28/83 (34%)
		ANK repeat	230..261	CDD:293786	13/30 (43%)
		Ank_2	235..324	CDD:289560	28/96 (29%)
		ANK	258..414	CDD:238125	36/166 (22%)
		ANK repeat	299..329	CDD:293786	8/29 (28%)
		Ion_trans	501..665	CDD:278921	47/163 (29%)
TRPV5	NP_062815.3	trp	2..705	CDD:273311	158/667 (24%)
		ANK 1. /evidence=ECO:0000255	44..74		0/1 (0%)
		ANK repeat	46..76	CDD:293786	0/3 (0%)
		ANK 2. /evidence=ECO:0000255	78..107		11/31 (35%)
		ANK	79..202	CDD:238125	47/137 (34%)
		ANK repeat	79..114	CDD:293786	10/37 (27%)
		ANK 3. /evidence=ECO:0000255	116..145		9/28 (32%)
		ANK repeat	117..147	CDD:293786	9/29 (31%)
		ANK	161..308	CDD:238125	43/154 (28%)
		ANK repeat	162..193	CDD:293786	13/30 (43%)
		ANK 4. /evidence=ECO:0000255	162..191		12/28 (43%)
		ANK 5. /evidence=ECO:0000255	195..228		6/32 (19%)
		ANK 6. /evidence=ECO:0000255	239..268		8/28 (29%)
		Interaction with S100A10. /evidence=ECO:0000250\|UniProtKB:P69744	598..602		0/3 (0%)
		Involved in Ca(2+)-dependent inactivation. /evidence=ECO:0000250	650..653		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..675		3/22 (14%)
		Involved in Ca(2+)-dependent inactivation. /evidence=ECO:0000250	700..729		8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145077
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3588
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	1	1.000	-	-		mtm8438
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.760