DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment iav and trpv4

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_005165208.1	Gene:	trpv4 / 557850	ZFINID:	ZDB-GENE-030912-7	Length:	859	Species:	Danio rerio

Alignment Length:	664	Identity:	169/664 - (25%)
Similarity:	280/664 - (42%)	Gaps:	130/664 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LRVFPNLAL-DVMEGEEYLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANP 218
            ||.|.|... ||.    |.|..|||::|.....:.|..|:|.|||:|.:|.|.||.|||:
Zfish   233 LREFINTPFRDVY----YRGQMALHIAIERRCKQYVELLVEKGADVHAQARGRFFQPRDE----- 288

  Fly   219 AKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCG---SDPDAQDSFGNMILH----------- 269
                  .|..|.||.||:.|||.....:.:.|.:.|   :|...|||.||.:||
Zfish   289 ------GGYFYFGELPLSLAACTNQPDMVHYLTENGHKKADLRRQDSRGNTVLHALVHIADNTRD 347

  Fly   270 -----------MVVVCDKLDMFGYALRHPKTPAKNGIVNQTGLTPLTLACKLGRAEVF-----RE 318
                       :::.|.||        :|....:| |:|..|::||.:|.|||:..||     ||
Zfish   348 NTRFVTKMFDLLLIKCAKL--------YPDCNLEN-ILNNDGMSPLMMAAKLGKIGVFQHIIRRE 403

  Fly   319 MLELSAREF------WRYSNITCSGYPLNALDTLLPDGRTNWNSALFIILNGTKPEHL-DMLDGG 376
            :.:..||..      |.|..:..:.|.|::|||...:     .|.|.|::..:|.|:. :||...
Zfish   404 IKDEEARHLSRKFKDWAYGPVYSNLYDLSSLDTCGEE-----VSVLEILVYNSKIENRHEMLAVE 463

  Fly   377 IIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQ 441
            .|..||..||:.||...|...:......::..::..|.||          |.|....|   .|..
Zfish   464 PINELLRAKWQKFAAVTFYISVFSYLVTMIIFTLVAYYRP----------SVGKPPYA---YDTT 515

  Fly   442 SDEGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKNQGLSAFLKQLSHAPA------- 499
            .|:             .|...|..|:...|.:.:    ..||:    .|||:.....:
Zfish   516 EDK-------------VRLAGEIITVGSGLFFFV----TNIKD----LFLKKCPGVNSIFVDGSF 559

  Fly   500 KAIFLFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGD 564
            :.::...::|:|......|.| .:...::::||:...|...::|...::|||.:..||..::..|
Zfish   560 QLLYFIYSVLVLVSAALYLSG-IEAYVSVMVFALTLGWMNTLYFTRGLKLTGTYSIMIQKILIKD 623

  Fly   565 MFTFGIIYCIVLCGFSQAFYFLY-------------KGHPQVQSTMFNTYTSTWMALFQTTLGDY 616
            :|.|.::|.:.:.|::.|...|.             ..:|:.:.|  ||::...:.||:.|:|..
Zfish   624 LFRFLLVYVLFMIGYASALVSLLTICPDKDTCKENCPTYPECRDT--NTFSEFLLDLFKLTIGIG 686

  Fly   617 NYPD-LNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLE 680
            :..: |....||.:...:.|.::|...:||||||||:||.|...|.::|:|.|..|||..::.:|
Zfish   687 DLDNMLKGAQYPAVFLILLVTYIILTFVLLLNMLIALMGETVGQVSKESKKIWKLQWATTILDIE 751

  Fly   681 RAVPQADAKGYLEAYSIPLGPSDDSGFEVRGVMVIKSKSKTRAKQRKGAVSNWKRVGRVTLTALK 745
            |:.|....:.:.....:.:|...|...:.|....:.....:...|..|.::  :..|:..|:
Zfish   752 RSFPVCLRRSFRVGEMVTVGKGLDGKPDKRWCFRVDEVKWSHWNQNLGIIN--EDPGQKDLS--- 811

  Fly   746 KRGMTGEEMRRLMW 759
            :....|..:||..|
Zfish   812 EHTQGGRGLRRDRW 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	19/47 (40%)
		ANK repeat	132..164	CDD:293786	4/9 (44%)
		ANK	173..315	CDD:238125	52/166 (31%)
		ANK repeat	173..203	CDD:293786	12/29 (41%)
		Ank_2	177..261	CDD:289560	29/86 (34%)
		ANK repeat	230..261	CDD:293786	10/33 (30%)
		Ank_2	235..324	CDD:289560	32/118 (27%)
		ANK	258..414	CDD:238125	49/189 (26%)
		ANK repeat	299..329	CDD:293786	13/40 (33%)
		Ion_trans	501..665	CDD:278921	45/177 (25%)
trpv4	XP_005165208.1	trp	159..857	CDD:273311	169/664 (25%)
		ANK repeat	247..278	CDD:293786	12/30 (40%)
		ANK	248..400	CDD:238125	54/171 (32%)
		ANK repeat	294..328	CDD:293786	10/33 (30%)
		ANK repeat	330..364	CDD:293786	4/33 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578395
Domainoid	1	1.000	73	1.000	Domainoid score	I9182
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4007
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6594
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.760