DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and TRPV6

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_061116.5	Gene:	TRPV6 / 55503	HGNCID:	14006	Length:	765	Species:	Homo sapiens

Alignment Length:	704	Identity:	181/704 - (25%)
Similarity:	301/704 - (42%)	Gaps:	127/704 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 KWEDHKACWQMQYRGALGESLLHVLIICDSKVHTKLARVLLRVFPNLALDVMEGEEYLGASALHL 179
            |:||.|    :..|||:||:.||:..:.|   :.:.|.||:...|.|..:.|..|.|.|.:|||:
Human   106 KYEDCK----VHQRGAMGETALHIAALYD---NLEAAMVLMEAAPELVFEPMTSELYEGQTALHI 163

  Fly   180 SIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANPAKSTDYEGLAYMGEYPLAWAACCANE 244
            ::...|..||..|:...|.:..||.|:.|      |.:|.      .|.|.||:||::|||..:|
Human   164 AVVNQNMNLVRALLARRASVSARATGTAF------RRSPC------NLIYFGEHPLSFAACVNSE 216

  Fly   245 SVYNLLVDCGSDPDAQDSFGNMILHMVVV-------CDKLDMFGYALRHPKTPAKNG-------- 294
            .:..||::.|:|..||||.||.:||::::       |   .|:...|.:.    ::|
Human   217 EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFAC---QMYNLLLSYD----RHGDHLQPLDL 274

  Fly   295 IVNQTGLTPLTLACKLGRAEVFREMLELSAREFWRYSNITCSGYPLNALDTLLPDGRTNWNSALF 359
            :.|..||||..||...|...:|:.:::......|.|..:|.:.|.|..:|:     ..:..|.|.
Human   275 VPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDS-----SGDEQSLLE 334

  Fly   360 IILNGTKPEHLDMLDGGIIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSV-SVY--LRPAHDGE 421
            :|:...|.|...:||...::.|:..|||.:.:..|.....|...:::|.:: .:|  |:|..:..
Human   335 LIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNR 399

  Fly   422 AEDEDSE--GSDASAAALLDIQSDEGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKN 484
            ....|:.  .......|.:..:.|              .|...|..|::|.:..::.:..| |..
Human   400 TSPRDNTLLQQKLLQEAYMTPKDD--------------IRLVGELVTVIGAIIILLVEVPD-IFR 449

  Fly   485 QGLSAFLKQ-LSHAPAKAIFLFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIR 548
            .|::.|..| :...|...:.:....::|..:..||| ....|...:.||:...|..:|:||...:
Human   450 MGVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLI-SASGEVVPMSFALVLGWCNVMYFARGFQ 513

  Fly   549 LTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLYKGHPQVQSTMFNTYTSTWMALFQT-- 611
            :.|||..||..||.||:..|..:..:|:.||:.|||.:::.....:...|..|.   ||||.|
Human   514 MLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYP---MALFSTFE 575

  Fly   612 ---TL--GDYNYPDLNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQ 671
               |:  |..||    ....|.:....:..|.|...:|:||:||||||:|:..|..:.::.|..|
Human   576 LFLTIIDGPANY----NVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQ 636

  Fly   672 WAKIVVTLERAVPQ---------ADAKGYLEAYSIPLGPSDD----------SGFEVRGV----- 712
            .....|.|||.:|:         ....|..:.:.:.:....|          ..|..||.
Human   637 IVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDK 701

  Fly   713 ---------------MVIKSKSKTRAKQRKGAVSNWKRVGRVTLTALKKRGMTG 751
                           :.:...|.:|:..|..|  ||:|:.:.||    :|.:.|
Human   702 DSVEKLELGCPFSPHLSLPMPSVSRSTSRSSA--NWERLRQGTL----RRDLRG 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	25/74 (34%)
		ANK repeat	132..164	CDD:293786	10/31 (32%)
		ANK	173..315	CDD:238125	49/156 (31%)
		ANK repeat	173..203	CDD:293786	9/29 (31%)
		Ank_2	177..261	CDD:289560	28/83 (34%)
		ANK repeat	230..261	CDD:293786	13/30 (43%)
		Ank_2	235..324	CDD:289560	30/103 (29%)
		ANK	258..414	CDD:238125	42/173 (24%)
		ANK repeat	299..329	CDD:293786	8/29 (28%)
		Ion_trans	501..665	CDD:278921	52/170 (31%)
TRPV6	NP_061116.5	trp	52..698	CDD:273311	170/645 (26%)
		ANK 1	84..114		4/11 (36%)
		ANK repeat	86..116	CDD:293786	4/13 (31%)
		ANK repeat	118..150	CDD:293786	10/34 (29%)
		ANK 2	118..147		10/31 (32%)
		ANK	119..242	CDD:238125	49/137 (36%)
		Interaction with calmodulin. /evidence=ECO:0000250	133..143		3/9 (33%)
		ANK repeat	156..187	CDD:293786	9/30 (30%)
		ANK 3	156..185		9/28 (32%)
		ANK	201..>303	CDD:238125	34/108 (31%)
		ANK repeat	202..233	CDD:293786	13/30 (43%)
		ANK 4	202..231		12/28 (43%)
		ANK 5	235..277		8/48 (17%)
		ANK 5	279..308		8/28 (29%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:29258289	581..585		1/3 (33%)
		Interaction with S100A10. /evidence=ECO:0000250	638..642		0/3 (0%)
		Interaction with calmodulin. /evidence=ECO:0000269\|PubMed:11248124, ECO:0000269\|PubMed:15184369	731..751		8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145079
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3588
Isobase	1	0.950	-	0	Normalized mean entropy	S5793
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	1	1.000	-	-		mtm8438
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.710