DRSC/TRiP Functional Genomics Resources

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Protein Alignment iav and TRPV6

DIOPT Version :10

Sequence 1:NP_572353.1 Gene:iav / 31621 FlyBaseID:FBgn0086693 Length:1123 Species:Drosophila melanogaster
Sequence 2:NP_061116.5 Gene:TRPV6 / 55503 HGNCID:14006 Length:765 Species:Homo sapiens


Alignment Length:704 Identity:181/704 - (25%)
Similarity:301/704 - (42%) Gaps:127/704 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 KWEDHKACWQMQYRGALGESLLHVLIICDSKVHTKLARVLLRVFPNLALDVMEGEEYLGASALHL 179
            |:||.|    :..|||:||:.||:..:.|   :.:.|.||:...|.|..:.|..|.|.|.:|||:
Human   106 KYEDCK----VHQRGAMGETALHIAALYD---NLEAAMVLMEAAPELVFEPMTSELYEGQTALHI 163

  Fly   180 SIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANPAKSTDYEGLAYMGEYPLAWAACCANE 244
            ::...|..||..|:...|.:..||.|:.|      |.:|.      .|.|.||:||::|||..:|
Human   164 AVVNQNMNLVRALLARRASVSARATGTAF------RRSPC------NLIYFGEHPLSFAACVNSE 216

  Fly   245 SVYNLLVDCGSDPDAQDSFGNMILHMVVV-------CDKLDMFGYALRHPKTPAKNG-------- 294
            .:..||::.|:|..||||.||.:||::::       |   .|:...|.:.    ::|        
Human   217 EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFAC---QMYNLLLSYD----RHGDHLQPLDL 274

  Fly   295 IVNQTGLTPLTLACKLGRAEVFREMLELSAREFWRYSNITCSGYPLNALDTLLPDGRTNWNSALF 359
            :.|..||||..||...|...:|:.:::......|.|..:|.:.|.|..:|:     ..:..|.|.
Human   275 VPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDS-----SGDEQSLLE 334

  Fly   360 IILNGTKPEHLDMLDGGIIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSV-SVY--LRPAHDGE 421
            :|:...|.|...:||...::.|:..|||.:.:..|.....|...:::|.:: .:|  |:|..:..
Human   335 LIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNR 399

  Fly   422 AEDEDSE--GSDASAAALLDIQSDEGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKN 484
            ....|:.  .......|.:..:.|              .|...|..|::|.:..::.:..| |..
Human   400 TSPRDNTLLQQKLLQEAYMTPKDD--------------IRLVGELVTVIGAIIILLVEVPD-IFR 449

  Fly   485 QGLSAFLKQ-LSHAPAKAIFLFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIR 548
            .|::.|..| :...|...:.:....::|..:..||| ....|...:.||:...|..:|:||...:
Human   450 MGVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLI-SASGEVVPMSFALVLGWCNVMYFARGFQ 513

  Fly   549 LTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLYKGHPQVQSTMFNTYTSTWMALFQT-- 611
            :.|||..||..||.||:..|..:..:|:.||:.|||.:::.....:...|..|.   ||||.|  
Human   514 MLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYP---MALFSTFE 575

  Fly   612 ---TL--GDYNYPDLNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQ 671
               |:  |..||    ....|.:....:..|.|...:|:||:||||||:|:..|..:.::.|..|
Human   576 LFLTIIDGPANY----NVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQ 636

  Fly   672 WAKIVVTLERAVPQ---------ADAKGYLEAYSIPLGPSDD----------SGFEVRGV----- 712
            .....|.|||.:|:         ....|..:.:.:.:....|          ..|..||.     
Human   637 IVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDK 701

  Fly   713 ---------------MVIKSKSKTRAKQRKGAVSNWKRVGRVTLTALKKRGMTG 751
                           :.:...|.:|:..|..|  ||:|:.:.||    :|.:.|
Human   702 DSVEKLELGCPFSPHLSLPMPSVSRSTSRSSA--NWERLRQGTL----RRDLRG 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
iavNP_572353.1 TRPV 126..757 CDD:454755 177/693 (26%)
ANK repeat 132..164 CDD:293786 10/31 (32%)
ANK repeat 173..203 CDD:293786 9/29 (31%)
ANK repeat 230..261 CDD:293786 13/30 (43%)
ANK repeat 299..329 CDD:293786 8/29 (28%)
TRPV6NP_061116.5 TRPV5-6 69..677 CDD:411976 166/624 (27%)
ANK 1. /evidence=ECO:0000255 84..114 4/11 (36%)
ANK repeat 86..116 CDD:293786 4/13 (31%)
ANK repeat 118..150 CDD:293786 10/34 (29%)
ANK 2. /evidence=ECO:0000255 118..147 10/31 (32%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q91WD2 133..143 3/9 (33%)
ANK repeat 156..187 CDD:293786 9/30 (30%)
ANK 3. /evidence=ECO:0000255 156..185 9/28 (32%)
ANK repeat 202..233 CDD:293786 13/30 (43%)
ANK 4. /evidence=ECO:0000255 202..231 12/28 (43%)
ANK 5. /evidence=ECO:0000255 235..277 8/48 (17%)
ANK 6. /evidence=ECO:0000255 279..308 8/28 (29%)
Selectivity filter. /evidence=ECO:0000305|PubMed:29258289 581..585 1/3 (33%)
Interaction with S100A10. /evidence=ECO:0000250|UniProtKB:Q91WD2 638..642 0/3 (0%)
Interaction with calmodulin. /evidence=ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:15184369 731..751 8/25 (32%)

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