DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and nan

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster

Alignment Length:	820	Identity:	260/820 - (31%)
Similarity:	404/820 - (49%)	Gaps:	131/820 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LYKLADYKRGGDLID----AINSGGLIAVEQLIREQFGVFMYNDGKGQV--INRAEFLRWKYRDH 96
            |||..:.|.||.|:|    |..:.....::..|:.:...|:||.|.|:.  |::...||.:.|..
  Fly    23 LYKFVNLKGGGLLVDMMKRACQTKQFAEIDHAIKTKVEPFLYNKGAGRYFPISKLVLLRNRDRPR 87

  Fly    97 TEVTIPIEA------SLSIHDPLGKWEDHK----------ACWQMQYRGALGESLLHVLIICDSK 145
            |.....|.|      ..:|||...:..:.:          .||.:..|||:||::||:.::..|.
  Fly    88 TRQLPEIRALENPDDDFNIHDYCPEVSEAEYISNPTAYRFVCWDLNMRGAVGETILHLCLLNASS 152

  Fly   146 VHTKLARVLLRVFPNLALDVMEGEEYLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLP 210
            :|..||:.||:.:|.|.||:...:||.|.|.||::|...:..:|..|::|.||:.:|..|:|...
  Fly   153 LHADLAKRLLKFYPKLILDIYMSDEYYGESVLHIAIVNEDPAMVKYLLDANADVQERCCGAFMSA 217

  Fly   211 RDQQRANP----------AKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCGSDPDAQDSFGN 265
            .|.:.:..          ...|:|:|..|.|||||::|||.:.|..:.|::..|:|||.||:.||
  Fly   218 EDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQEECFRLVLARGADPDFQDTNGN 282

  Fly   266 MILHMVVVCDKLDMF--GYALRHPKTPAKNGIVNQTGLTPLTLACKLGRAEVFREMLELSAREFW 328
            .:|||:|:.:|::||  ||     :......|.|...|||||||.||||.|:|..::.:....:|
  Fly   283 TVLHMLVIYEKIEMFDVGY-----EVGTNIHIKNIQNLTPLTLAAKLGRVEMFFHVMSIEREIYW 342

  Fly   329 RYSNITCSGYPLNALDTLLPD-GRTNWNSALFIILNGTKPEHLDMLDGGIIQRLLEEKWKTFAQN 392
            :..:|||:.|||..:||:..: |..|.:|.|..::.|.|.|||::|||.:|. ||:.||.||.::
  Fly   343 QLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGDKLEHLELLDGVVID-LLKTKWDTFCKS 406

  Fly   393 QFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQSDEGDSGGGD------ 451
            :|.|:..:.:.:.|....|..|||..|  |:|||.:|::::.|     :||.....|.|
  Fly   407 RFYKQFYMFALYFLISLFSFILRPGPD--AKDEDEDGANSTTA-----KSDLYRQNGSDSYHLHS 464

  Fly   452 -------------------YNAQTV------------------------ARYCAEFATLVGVLSY 473
                               |:...|                        .|..||....||.:.|
  Fly   465 KRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFVGAILY 529

  Fly   474 VIFQQGDEIKNQGLSAFLKQLSHAPAKAIFLFSNLLILACIPFRLIG---DTDTEEAILIFAVPG 535
            ::... .|.:..||..|::.|..||::.:||||..|::. ||:..:.   :.|....::|.....
  Fly   530 LLVAL-REARFLGLKMFIENLMTAPSRVMFLFSCALMMT-IPWLRVSCLTEIDDHVTVVIMLTTA 592

  Fly   536 SWFLLMFFAGAIRLTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLY-----KGHPQVQS 595
            .:||  ||....:..||||.|||.|:.||:..|..||.:.:.|||||||.::     ...|:.|.
  Fly   593 PYFL--FFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQD 655

  Fly   596 TMFNTYTS---TWMALF---QTTLGDYNYPDLNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMG 654
            ...|...|   :.:|:|   .|..||| |..:..|.:...:|.:|.:||:.|.:||:||||||||
  Fly   656 AESNPMPSPMESIVAMFLMSLTNFGDY-YGAMVSTQHEYEAKILFFLFMVIVSVLLVNMLIAMMG 719

  Fly   655 NTYVTVIEQSEKEWMKQWAKIVVTLERAVPQAD-AKGYLEAYSIPLGPSDDSGFEVRGVMVIKSK 718
            |||..:.| ...||.:|||:||:.:||:||.|: .|.::: ||       .|..:.|..:|::..
  Fly   720 NTYQKIAE-IRNEWQRQWARIVLVVERSVPPAERLKNFMQ-YS-------QSMSDGRRALVLRLN 775

  Fly   719 SKTRAKQRKGAVSNWKRVGRVTLTALKKRGMTGE--EMRR 756
            .....|:....|...||:.:   ...|||.|..|  .:||
  Fly   776 MTEEEKEEMKEVQEMKRIHQ---RFAKKRQMEREARALRR 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	29/74 (39%)
		ANK repeat	132..164	CDD:293786	12/31 (39%)
		ANK	173..315	CDD:238125	58/153 (38%)
		ANK repeat	173..203	CDD:293786	10/29 (34%)
		Ank_2	177..261	CDD:289560	30/93 (32%)
		ANK repeat	230..261	CDD:293786	14/30 (47%)
		Ank_2	235..324	CDD:289560	38/90 (42%)
		ANK	258..414	CDD:238125	61/158 (39%)
		ANK repeat	299..329	CDD:293786	13/29 (45%)
		Ion_trans	501..665	CDD:278921	64/177 (36%)
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	29/77 (38%)
		ANK	<131..200	CDD:238125	25/68 (37%)
		ANK repeat	138..174	CDD:293786	14/35 (40%)
		ANK	178..329	CDD:238125	59/155 (38%)
		ANK repeat	179..229	CDD:293786	14/49 (29%)
		Ank_2	184..311	CDD:289560	44/131 (34%)
		ANK repeat	231..278	CDD:293786	18/46 (39%)
		ANK repeat	280..311	CDD:293786	12/35 (34%)
		Ion_trans	519..727	CDD:278921	74/212 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445554
Domainoid	1	1.000	73	1.000	Domainoid score	I9182
eggNOG	1	0.900	-	-		E1_KOG3676
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4007
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14659at50557
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	1	1.000	-	-		mtm6594
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10582
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
	10	9.900