DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and Trpv2

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001257726.1	Gene:	Trpv2 / 29465	RGDID:	3965	Length:	761	Species:	Rattus norvegicus

Alignment Length:	785	Identity:	183/785 - (23%)
Similarity:	287/785 - (36%)	Gaps:	213/785 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 EFLRW--KY-------RDHTEVTIPIEASLSIHDPLGKWEDHKACWQMQYRGALGESLLHVLIIC 142
            |:|||  ||       ...|..|..::|.|::.|.:      .||
  Rat    97 EYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGV------NAC-------------------- 135

  Fly   143 DSKVHTKLARVLLRVFPNLALDVMEG------------EEYLGASALHLSIAYSNNELVADLIEA 195
                          :.|.|.:|...|            |.|.|.||||::|...:.:.|..|:|.
  Rat   136 --------------IMPLLQIDKDSGNPKPLVNAQCIDEFYQGHSALHIAIEKRSLQCVKLLVEN 186

  Fly   196 GADIHQRAIGSFFLPRDQQRANPAKSTDYEGLA-YMGEYPLAWAACCANESVYNLLVDCGSDP-- 257
            |||:|.||.|.||             ..::|.. |.||.||:.|||.....|...|::....|
  Rat   187 GADVHLRACGRFF-------------QKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPAS 238

  Fly   258 -DAQDSFGNMILH-MVVVCDK--------LDMFGYAL----RHPKTPAKNGIVNQTGLTPLTLAC 308
             :|.||.||.:|| :|::.|.        :.|:...|    |...|.....|.|..|||||.||.
  Rat   239 LEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAA 303

  Fly   309 KLGRAEVFREMLELSAREF-------------WRYSNITCSGYPLNALDTLLPDGRTNW--NSAL 358
            |.|:.|:||.:|:   |||             |.|..:..|.|.|:::|        :|  ||.|
  Rat   304 KEGKIEIFRHILQ---REFSGPYQPLSRKFTEWCYGPVRVSLYDLSSVD--------SWEKNSVL 357

  Fly   359 FIILNGTK-PEHLDMLDGGIIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEA 422
            .||....| |....|:....:.:||:|||.......|......| .::...:|..|.:|:.|..|
  Rat   358 EIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACYL-VYMFIFTVVAYHQPSLDQPA 421

  Fly   423 EDEDSEGSDASAAALLDIQSDEGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKNQGL 487
                             |.|.:                 |.|...:.:|.:::...|      |:
  Rat   422 -----------------IPSSK-----------------ATFGESMLLLGHILILLG------GI 446

  Fly   488 SAFLKQLSH--------------APAKAIFLFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWF 538
            ...|.||.:              :..:.:||...||.:.....|.: :|:....:|:.::...|.
  Rat   447 YLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQALLTVLSQVLRFM-ETEWYLPLLVLSLVLGWL 510

  Fly   539 LLMFFAGAIRLTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLYKGHPQVQSTMFNTYTS 603
            .|:::....:.||.:..||..:|..|:..|.::|.:.|.||:.|...|.:.....::...|..|.
  Rat   511 NLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDNNSTV 575

  Fly   604 T--------------------WMALFQTTLGDYNYPDLNQTTYPNLSKTVFVIFMIFVPILLLNM 648
            |                    .:.||:.|:|........|..:..:...:.:.:::...:|||||
  Rat   576 TEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNM 640

  Fly   649 LIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQADAKGYLEAYSIPLGPSDDSGFEVRGVM 713
            |||:|..|...|.:.|...|..|.|..|:.:|........|.:.|...:.:|...|...:.|...
  Rat   641 LIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGTRGDGTPDERWCF 705

  Fly   714 VIKSKSKTRAKQRKGAVSNWKRVGRVTLTALKK----RGMTGEEMRRLMW-GRASISSPVKVTKQ 773
            .::.             .||. ....||..|.:    .|:||.:...... |:.|.|....:..|
  Rat   706 RVEE-------------VNWV-AWEKTLPTLSEDPSGPGITGNKKNPTSKPGKNSASEEDHLPLQ 756

  Fly   774 KLKDP 778
            .|:.|
  Rat   757 VLQSP 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	19/86 (22%)
		ANK repeat	132..164	CDD:293786	2/31 (6%)
		ANK	173..315	CDD:238125	54/158 (34%)
		ANK repeat	173..203	CDD:293786	13/29 (45%)
		Ank_2	177..261	CDD:289560	28/87 (32%)
		ANK repeat	230..261	CDD:293786	11/33 (33%)
		Ank_2	235..324	CDD:289560	35/104 (34%)
		ANK	258..414	CDD:238125	54/184 (29%)
		ANK repeat	299..329	CDD:293786	16/42 (38%)
		Ion_trans	501..665	CDD:278921	41/183 (22%)
Trpv2	NP_001257726.1	Required for interaction with SLC50A1. /evidence=ECO:0000269\|PubMed:14991772	1..390		100/356 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..75
		TRPV2	71..710	CDD:411981	169/731 (23%)
		ANK repeat	164..194	CDD:293786	13/29 (45%)
		ANK repeat	209..243	CDD:293786	11/33 (33%)
		ANK repeat	245..279	CDD:293786	8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..587		3/22 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..761		9/40 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.710