DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and ocr-3

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_510520.4	Gene:	ocr-3 / 188364	WormBaseID:	WBGene00003840	Length:	818	Species:	Caenorhabditis elegans

Alignment Length:	793	Identity:	232/793 - (29%)
Similarity:	377/793 - (47%)	Gaps:	129/793 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LYKLADYKRGGDLID----AINSGGLIAVEQLIREQFGVFMYNDGKGQV--INRAEFLRWKYR-- 94
            ||.|.|.:.||.|..    |.:||....:|:.:......::||.|||::  |::...:|.|.|
Worm    12 LYSLVDEQGGGILSPWIKYARSSGDYSILEEYLDTAVKSYLYNGGKGKLVPISQLVTIRNKQRNA 76

  Fly    95 -------------------DHTEVTIPIEASLSIHDPL------------GK--WEDHKACWQMQ 126
                               :|.:     :.:||..|.|            |:  ::..:..|.|.
Worm    77 LLGALRRKKGRGKSGPNILEHID-----QDALSSGDFLKALKVLDGGMIKGRRSFKYRELVWDMD 136

  Fly   127 YRGALGESLLHVLIICDSKVHTKLARVLLRVFPNLALDVMEGEEYLGASALHLSIAYSNNELVAD 191
            .||.|||:||||.::.::....:|.:.:...||.:..|:...|||.|.|.||.:|...:.|:|..
Worm   137 QRGRLGENLLHVCMLLNTADMNELVKQMTYRFPKIVNDIFLSEEYYGLSPLHQAIVNEDLEMVYF 201

  Fly   192 LIEAGADIHQRAIGSFFLPRDQQRANP----------AKSTDYEGLAYMGEYPLAWAACCANESV 246
            |...|||:|||..||||...||:.:..          .:||.|.|..|.|||||::|||......
Worm   202 LCRKGADVHQRCYGSFFCADDQKASRTDSLEHEWVDLVQSTKYTGQMYWGEYPLSFAACTNQVDC 266

  Fly   247 YNLLVDCGSDPDAQDSFGNMILHMVVVCDKLDMFGYALRHPKTPAKNGIVNQTGLTPLTLACKLG 311
            :.||....:||:..|:.||.:||:.|:.|..:||..|:   :..|...:.|...||||.||.:|.
Worm   267 FRLLRAMKADPNMPDTNGNTVLHLTVIHDLPEMFMLAV---ELGANLHVRNNLKLTPLALAARLA 328

  Fly   312 RAEVFREMLELSAREFWRYSNITCSGYPLNALDTL-LPDGRTNWNSALFIILNGTKPEHLDMLDG 375
            :..::..:||......|||..:.|..||||.:||: ..||..|.||.:..::.|.|.:||:..|
Worm   329 KKHIYDLILECDMDISWRYGPVVCKAYPLNDVDTINESDGSLNPNSVIANVVYGDKVDHLEFFD- 392

  Fly   376 GIIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYL----RPAH---DGEAEDED------- 426
            |:|:.:||.||:||.:.|.   .:.|:.::..|:| .||    |.||   ..|.|:|.
Worm   393 GLIEEVLESKWETFGKKQL---FMSLAGYIYFLAV-FYLAFMTRDAHILPSDEDENEKFGMIELD 453

  Fly   427 --------SEG----SDASAAALLDIQSDEGDSGGGDYN--AQTVARYCAEFATLVGVLSYVIFQ 477
                    |||    ...:.|.:.:.::........||:  :|.: |..:|...|:.|:... |:
Worm   454 FSNFTNILSEGLSLREHLAIARMAEREALPAHCHLWDYSGPSQQI-RMISEILCLLAVVIRT-FK 516

  Fly   478 QGDEIKNQGLSAFLKQLSHAPAKAIFLFSNLLILACIPFRL---IGDT--DTEEAILIFAVPGSW 537
            ...:....|:|.:...:...|.|.:..|..:|:|..:|.|:   :.|:  ..|..:::..|..|.
Worm   517 DCIDAHRTGVSRWWNSIKAFPEKVLHKFCQILVLCTVPLRVGCYLDDSFLVIENLLVVCIVIMST 581

  Fly   538 FLLMFFAGAIRLTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLYKG--HPQVQSTMFNT 600
            ...:|:..:::..||||.|:|.:|..||..|.:||...|.||:|||:.::|.  ..::.....:.
Worm   582 LHFLFYCRSLKFVGPFVLMVYKIIVRDMLRFLLIYSFFLMGFAQAFFVIFKSCERAEIAYQKAHN 646

  Fly   601 YTST--------------W---MALFQTTLGDYN--YPDLNQ--TTYPNLSKTVFVIFMIFVPIL 644
            ||..              |   |.:|..::|::.  |.:||:  ::....||..|::|.:.|.::
Worm   647 YTEDDEYIEKFENIMEDGWEAVMRMFIMSVGEFGALYKNLNECKSSIAPQSKVFFILFELIVTVM 711

  Fly   645 LLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQADAKGYLEAYSIPLGPSDDSGFEV 709
            |||:|||||..||..:.| :||||.:|||::::.||::...::....|..|:.|: .||    :.
Worm   712 LLNLLIAMMTRTYEKIAE-TEKEWKRQWAQVILMLEQSSSASERLLSLYRYTRPI-RSD----KR 770

  Fly   710 RGVMVIKSKSKTR 722
            |...|:|.||..|
Worm   771 RRAFVVKVKSNDR 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	28/74 (38%)
		ANK repeat	132..164	CDD:293786	9/31 (29%)
		ANK	173..315	CDD:238125	56/151 (37%)
		ANK repeat	173..203	CDD:293786	13/29 (45%)
		Ank_2	177..261	CDD:289560	35/93 (38%)
		ANK repeat	230..261	CDD:293786	12/30 (40%)
		Ank_2	235..324	CDD:289560	29/88 (33%)
		ANK	258..414	CDD:238125	53/156 (34%)
		ANK repeat	299..329	CDD:293786	9/29 (31%)
		Ion_trans	501..665	CDD:278921	54/191 (28%)
ocr-3	NP_510520.4	trp	136..801	CDD:273311	204/664 (31%)
		ANK repeat	182..242	CDD:293786	20/59 (34%)
		ANK repeat	244..281	CDD:293786	15/36 (42%)
		ANK repeat	283..314	CDD:293786	10/33 (30%)
		ANK repeat	316..346	CDD:293786	9/29 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I5088
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820