DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and ocr-1

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_001335506.1	Gene:	ocr-1 / 185101	WormBaseID:	WBGene00003838	Length:	850	Species:	Caenorhabditis elegans

Alignment Length:	844	Identity:	236/844 - (27%)
Similarity:	389/844 - (46%)	Gaps:	138/844 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LLYKLADYKRGGDLI------DAINSGGLIAVEQLIREQFGVFMYNDGKGQVINRAEFLRWKYRD 95
            ::||:.|...||.||      ..:||  .:.::..:.::...:|||.|||:::..||.::.:.::
Worm    28 VIYKMVDMHGGGILIKLARKCKELNS--FVLLDAYLDQEVRKYMYNGGKGKLMPVAELVKARNKE 90

  Fly    96 ----------------------------HTEVTIPIEASLSIHDPLGKW-----EDHKACWQMQY 127
                                        ..|:...::.:|.:.|..||.     :..:..|.:..
Worm    91 RNAKLGAFSRKKGKGKSGPNILDEFDQGQAEMAGDLKKALKLLDGGGKGGKSESKYREMVWSVDE 155

  Fly   128 RGALGESLLHVLIICDSKVHTKLARVLLRVFPNLALDVMEGEEYLGASALHLSIAYSNNELVADL 192
            ||::||:||.:.::..|.:|..:||.|:..||.|..|:...|||.|.|.|||:|...:.:..:.|
Worm   156 RGSMGENLLAICLLQGSALHNLIARRLINFFPKLINDICVSEEYYGLSPLHLAIVNQDAQFTSLL 220

  Fly   193 IEAGADIHQRAIGSFFLPRDQQRANP----------AKSTDYEGLAYMGEYPLAWAACCANESVY 247
            :..|||::||..|:||...||:.:..          .|:|:|.|..|.|||||::|.|.....::
Worm   221 LRLGADLNQRCYGAFFCADDQKASRTDSLEHEFVELTKNTNYTGSMYFGEYPLSFAICMGQHDLF 285

  Fly   248 NLLVDCGSDPDAQDSFGNMILHMVVVCDKLDMFGYALRHPKTPAKNGIVNQTGLTPLTLACKLGR 312
            .:|:...::..|||:.||..||:.|:.||:||....|   :......:.|:..||.||||.:|.:
Worm   286 RMLLAKKANLSAQDTNGNTALHLCVIHDKMDMLDAVL---EAGGNIRLANKQNLTALTLAARLAK 347

  Fly   313 AEVFREMLELSAREFWRYSNITCSGYPLNALDTL-LPDGRTNWNSALFIILNGTKPEHLDMLDGG 376
            ..:|.::|:|...:.|.|.:..|..|||..:||: ...|..|..|||.:::.|...:||:::| |
Worm   348 KTMFNKILQLECEKVWTYGSSQCVAYPLTKIDTIDETTGEMNDTSALSLVVYGESIQHLELMD-G 411

  Fly   377 IIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPA-------------HDGEAEDEDS- 427
            :|:::|:||||.:.:..:|:.||.......|...:..|||:             .|||.|..:|
Worm   412 LIEQILDEKWKAYGRALWLRSLLGFIFFYCCFVCAYMLRPSSATTEHLTRGRINDDGETESTNST 476

  Fly   428 -----EGSDASAAALLDIQSDEGDSGGGDYNA----QTVARYCAEFATLVGVLSYVIFQQGDEIK 483
                 ...|.....:.             |:|    ....|...|..|::.:|..::...|| |:
Worm   477 NYLQWHAIDTQCHLMY-------------YSAWPWYHGWFRLGCEIMTIIVMLFQILLDFGD-IR 527

  Fly   484 NQGLSAFLKQLSHAPAKAIFLFSNLLILACIPFRLIGD-------TDTEEAILIFAVPGSWFLLM 541
            ..|...:...|...|||.:|..:.|.|:..||.||...       .|...||:...:....||
Worm   528 RIGFQKWFNFLKAFPAKLMFKGAFLFIIISIPCRLACSFHEFFLTIDNTMAIISILLVTQHFL-- 590

  Fly   542 FFAGAIRLTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLY----------KGHPQVQST 596
            ::..||...||||.|:|::|..|:..|.:||.|.|.||||:||.::          |....:.|.
Worm   591 YYMRAIPFVGPFVLMVYTIIATDLVRFAMIYSIFLVGFSQSFYLIFTSCERDSTAIKKIDPMGSE 655

  Fly   597 MFNTYTSTWMALFQT---TLGDYNYPDLNQTTYPN-----LSKTVFVIFMIFVPILLLNMLIAMM 653
            ..|...:...||.:|   |:|:::......:...|     :.|.:||||..||.||..|:|||||
Worm   656 FNNIMENPVDALLRTFIMTIGEFSVLYREMSACDNFWMKWIGKLIFVIFETFVSILQFNLLIAMM 720

  Fly   654 GNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQADAKGYLEAYSIPLGPSDDSGFEVRGVMVIK-- 716
            ..||.|:. .:.|||.:|||::::.||..:..|..|.:|..|:.|.|.:.    .||..:|:.
Worm   721 TRTYETIF-LTRKEWKRQWAQVILMLEMGLSPASRKMHLLRYTRPTGINK----RVRSYVVVSKG 780

  Fly   717 -----SKSKTRAKQRKGAVSNWKRVGRVTLTALKKRGMTGEEMRRLMWGRASISSPVKVTKQKL 775
                 .|::..|::.|   ...||..|..|...|:|   ..|::.......|....::|.|:::
Worm   781 EGERTEKNELAAREAK---EEQKREERRQLLKKKQR---EHEVKAKALAMMSAKLHIEVKKRRI 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	28/74 (38%)
		ANK repeat	132..164	CDD:293786	12/31 (39%)
		ANK	173..315	CDD:238125	51/151 (34%)
		ANK repeat	173..203	CDD:293786	11/29 (38%)
		Ank_2	177..261	CDD:289560	29/93 (31%)
		ANK repeat	230..261	CDD:293786	9/30 (30%)
		Ank_2	235..324	CDD:289560	28/88 (32%)
		ANK	258..414	CDD:238125	52/156 (33%)
		ANK repeat	299..329	CDD:293786	10/29 (34%)
		Ion_trans	501..665	CDD:278921	60/188 (32%)
ocr-1	NP_001335506.1	trp	154..756	CDD:273311	192/622 (31%)
		ANK repeat	200..266	CDD:293786	21/65 (32%)
		ANK repeat	268..299	CDD:293786	9/30 (30%)
		ANK repeat	301..332	CDD:293786	10/33 (30%)
		MAP7	<781..>849	CDD:368554	13/64 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I5088
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920