DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and ocr-4

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_501172.2	Gene:	ocr-4 / 177506	WormBaseID:	WBGene00003841	Length:	756	Species:	Caenorhabditis elegans

Alignment Length:	748	Identity:	219/748 - (29%)
Similarity:	366/748 - (48%)	Gaps:	73/748 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QSSATACKCLLYKLADYKRGGDL----IDAINSGGLIAVEQLIREQFGVFMYNDGKGQVINRAEF 88
            ::...|....:.||||....|.|    :||:.:|....:::.|.|:....:||:|:|::|..::.
Worm    13 KNQVNASNNAINKLADMSGRGFLADLAMDAVRTGNHEELDKQILEKVQPMLYNNGQGEMIPLSDL 77

  Fly    89 LRWKYRDHTEVTIPIEASLSIHDPLGKWEDHKACWQMQYRGALGESLLHVLIICDSKVHTK-LAR 152
            :..::::.|..|..:        |:...|....||::..|||:||:|||...:.....|.| ||.
Worm    78 IAQRHKERTGNTFAV--------PVPSTECRFICWKLNSRGAVGETLLHTCFLAGLPNHMKLLAE 134

  Fly   153 VLLRVFPNLALDVMEGEEYLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQ---- 213
            .|:.:||.:..|....:||.|.:.||:.|...|.|.|..|:::|||:|.|..|:||...||
Worm   135 RLIAIFPKIINDFYLSDEYYGETVLHMGIVSENAEFVRYLLKSGADVHARCSGNFFTCDDQKGSR 199

  Fly   214 ------QRANPAKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCGSDPDAQDSFGNMILHMVV 272
                  :.|..:|.|.|.|..|.|||||::|||.:......:||..|:|.:|.|:.||.|||:..
Worm   200 TDHPEVEHAIISKHTKYPGHIYWGEYPLSFAACLSQPECIRMLVAHGADVNAADTNGNTILHICT 264

  Fly   273 VCDKLDMFGYALRHPKTPAKNGIVNQTGLTPLTLACKLGRAEVFREMLELSAREFWRYSNITCSG 337
            :.:..:||..||   ...|...|.|:..|||||||..|.:.|:.:.::|......|.|.....:.
Worm   265 IHENYEMFKMAL---SLGADLHIQNRQNLTPLTLAAFLAKKEMMQRIVEEERTVNWTYGRTQSAA 326

  Fly   338 YPLNALDTLLP-DGRTNWNSALFIILNGTKPEHLDMLDGGIIQRLLEEKWKTFAQNQFLKRLLIL 401
            |||..:|::.| .|..|..|.|.|.:.|.|.|||.:|. .::::|:..||..:.:.....:|.:.
Worm   327 YPLEHVDSIEPTSGSINQKSVLTIAVYGEKVEHLSLLP-HLLEQLVHHKWIAYGRKTLFAQLSMF 390

  Fly   402 STHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQSDEGDSGGGDYNAQTVARYCAEFAT 466
            ..:.:|::....|||:   ..|.:....:|  .....|.::...:...    ..|:..:......
Worm   391 CIYFICVTSCFLLRPS---PFERQQHIAND--LICFYDFKTRRFNESA----VSTIIYHLLHLIC 446

  Fly   467 LVGVLSYVIFQQGDEIKNQGLSAFLKQLSHAPAKAIFLFSNLLILACIPFRLIGDTDTEEAILIF 531
            :.|...|:: |....|||.|...::..||..|||||||||.:|::.....|:....:.|:.:.|.
Worm   447 VTGATLYLV-QALLHIKNVGYHLYVLGLSGFPAKAIFLFSCILMVITFFLRIFCLDEAEDIVWIV 510

  Fly   532 AVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLYKGH------ 590
            .|..:....:||....:..||||.|:|.:|..|:..|.:||.:::.|||||||.::.|:
Worm   511 IVLLTSLKFLFFCRGFKSVGPFVLMLYKIIIRDLMRFFLIYLVIVVGFSQAFYVIFLGYKRSDSG 575

  Fly   591 ---PQVQSTMFNTYTSTWMALFQTTLGDYN--YPDLNQTTYPNLSKTVFVIFMIFVPILLLNMLI 650
               |.:.|.:..:|    :.:|..:|.::.  :..|.:..:..:.|..||::|:.|.:||:||||
Worm   576 NREPSIMSNVAESY----VRMFIMSLTEFTVFFEQLEECEHTVIGKITFVVYMLLVTLLLINMLI 636

  Fly   651 AMMGNTYVTVIEQSEKEWMKQWAKIVVTLERAVPQADAKGYLEAYSIPLGPSDDSGFEVRGVMVI 715
            |||.||| |.:..:..||::||:.|::.:|::...|....|...|.|..    |.|.::  |:::
Worm   637 AMMTNTY-TEVSGNSLEWLRQWSAIILMMEQSFDPATRLRYQRRYGIRF----DGGEKL--VLLL 694

  Fly   716 KSK-------------SKTRAKQRKGAVSNWKR 735
            |.|             .:.|.|.|:...:|.:|
Worm   695 KDKMTEEEFECQRKKMHEERRKFREELRTNQRR 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	30/75 (40%)
		ANK repeat	132..164	CDD:293786	12/32 (38%)
		ANK	173..315	CDD:238125	58/151 (38%)
		ANK repeat	173..203	CDD:293786	12/29 (41%)
		Ank_2	177..261	CDD:289560	36/93 (39%)
		ANK repeat	230..261	CDD:293786	13/30 (43%)
		Ank_2	235..324	CDD:289560	32/88 (36%)
		ANK	258..414	CDD:238125	47/156 (30%)
		ANK repeat	299..329	CDD:293786	10/29 (34%)
		Ion_trans	501..665	CDD:278921	56/174 (32%)
ocr-4	NP_501172.2	trp	105..668	CDD:273311	182/581 (31%)
		ANK repeat	154..194	CDD:293786	16/39 (41%)
		ANK repeat	196..253	CDD:293786	19/56 (34%)
		ANK repeat	255..286	CDD:293786	11/33 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5793
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.770