DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and osm-9

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_500372.1	Gene:	osm-9 / 177117	WormBaseID:	WBGene00003889	Length:	937	Species:	Caenorhabditis elegans

Alignment Length:	1001	Identity:	361/1001 - (36%)
Similarity:	538/1001 - (53%)	Gaps:	155/1001 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LYKLADYKRGGDLIDAINSGGLIAVEQLIREQFGVFMYNDGKG-QVINRAEFLRWKYRDHTEVTI 101
            |||....::||:||:.....|...|.:...|:....:|::|:. :::..:::::||...:.::.:
Worm    39 LYKWVAVRKGGELINIYERDGEEGVLKFAEEKLLTILYDEGQNPKLVTYSDYIKWKKGVNVQLGL 103

  Fly   102 PIEASLSIHDPLGKWEDHKACWQMQYRGALGESLLHVLIICDSKVHTKLARVLLRVFPNLALDVM 166
            ..|   |:.....::::|.|.|::..||..||:|:|:|:..:.:|..::||:||:.||.:|.|:.
Worm   104 SEE---SVDMQQSRFKEHYALWKLNKRGVEGENLIHLLLNREQQVCYEIARILLKRFPGMANDIY 165

  Fly   167 EGEEYLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANPAKSTDYEGLAYMG 231
            .|:|..|.|||||:|.:.:.|.|:.|:.:.||::.||.|:||||.|.:..|  |.|||:|.||.|
Worm   166 LGDEQFGQSALHLAIVHDDYETVSLLLNSKADVNARACGNFFLPEDFKLTN--KITDYQGYAYYG 228

  Fly   232 EYPLAWAACCANESVYNLLVDCGSDPDAQDSFGNMILHMVVVCDKLDMFGYALRHPKTPAKNGIV 296
            |||||:|||..|:.:|:||:..|::|:.||||||.||||.|:.....|:.||:||...||...:|
Worm   229 EYPLAFAACFGNKDIYDLLIQFGANPNLQDSFGNTILHMCVINYSSSMYSYAVRHWAKPADPHVV 293

  Fly   297 NQTGLTPLTLACKLGRAEVFREMLELSAREFWRYSNITCSGYPLNALDTLLPDGRTNWNSALFII 361
            |..|.||||||.||||.::|.||||:...||||:|::|||.||||.|||:.|||.||::|||..:
Worm   294 NHAGFTPLTLATKLGRKQIFEEMLEIMKVEFWRFSDMTCSAYPLNTLDTIQPDGSTNYDSALMTV 358

  Fly   362 LNGTKPEHLDMLDGGIIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDED 426
            :||:.||||||:...:|||||.:|||.|||.:.::||::|...|:.||:.||:||........||
Worm   359 INGSTPEHLDMIGSEVIQRLLADKWKAFAQRKLIERLVLLIVQLITLSIVVYIRPTELPRLYMED 423

  Fly   427 SEGSDASAAALLDIQSDEGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKNQGLSAFL 491
            .:..|                         ..|...|..|::..:.:|.:||..||:.||:..:|
Worm   424 PQWDD-------------------------YIRTACELLTILNCIFFVGYQQLGEIRTQGMRGYL 463

  Fly   492 KQLSHAPAKAIFLFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTM 556
            :.|..|||||:|..:||.:|.||||||:...:.|||:.:||:||||..|:|||.:.:||||||.|
Worm   464 RNLKTAPAKAVFCIANLFLLLCIPFRLMKKHEIEEALFVFALPGSWIFLLFFARSAKLTGPFVQM 528

  Fly   557 IYSMITGDMFTFGIIYCIVLCGFSQAFYFLYK---GHPQVQST-------------MFNTYTSTW 605
            |||||.|||..|.||..|.|..|||.|||:.|   ...:::.|             .:||:..|:
Worm   529 IYSMIAGDMIRFAIISAIFLVSFSQVFYFVGKDMDAKQKLEDTNPHACRISGYTIYTYNTFPETF 593

  Fly   606 MALFQTTLGDYNYPDLNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMK 670
            :.||:.::|.|:|.:.:...|..|:||:||::|..:||:::|:|||||||||.|||.|:||.|.:
Worm   594 ITLFRASMGGYDYEEFSCANYQALTKTLFVLYMFVMPIMMINILIAMMGNTYTTVIAQAEKAWRQ 658

  Fly   671 QWAKIVVTLERAV-PQADAKGYLEAYSIPLGPSDDSGFEVRGVMVIKSKSKTRAKQRKGAVSNWK 734
            |:|:||:.|||:| .:..|...|| |||.|.....||.||||:||||...||||:|||.|:.|||
Worm   659 QYAQIVMVLERSVGKERLAASQLE-YSIRLDQEGSSGMEVRGLMVIKQTKKTRARQRKQAIYNWK 722

  Fly   735 RVGRVTLTALKKRGMTGEEMRRLMWGRASIS-------SPVKVTKQKLKDPYNLHTDSDFTNAMD 792
            .:||..:..:.|.|.  |:...|:.|...:.       .|.||..:. :.|..:.|..:.:..:.
Worm   723 TIGRKVIHTIDKVGT--EQAVLLLHGHDRLDRVYEDHVQPEKVPSRS-RTPTRIGTTLNSSKRLK 784

  Fly   793 MLTFASNPASSNGVTLRS--------VTAPPPA---------PPAPDPFRELIMMSDQ--RPETH 838
            ..|.....|.:|...:|:        ::|||..         .|:..|..|......|  |.|..
Worm   785 TTTMVVGAAVTNTHEVRTDEAVNSMLLSAPPSLSGEGATMDWQPSITPVEERSESKSQEDRSEAS 849

  Fly   839 DPHYFAGLQQLANKAFDLVEQTMKTQPQAPVAKKVDPLPVASVAKASPAAPATQATATAAAASDL 903
            .|:  .|:.              :|.|:|.     .|:.|...::          |....||..:
Worm   850 TPN--LGIH--------------RTTPKAD-----SPIRVVEYSR----------TIRVRAADTI 883

  Fly   904 MAMPLPISNLSNLFQDPKDIVDPKKLEEFMAMLAEVETEESDSGGPILGKLSLAKRTHNALSKAE 968
            .::.||                            .:.|:::.|..|           |.|:| ..
Worm   884 PSIELP----------------------------NIPTKQTSSTPP-----------HRAVS-PR 908

  Fly   969 IRRDQQGFEGHSHGQFQPMSSVWAPP 994
            :|.|.  |..|.    ||.|...:||
Worm   909 LRADM--FRRHQ----QPASFDQSPP 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	30/74 (41%)
		ANK repeat	132..164	CDD:293786	13/31 (42%)
		ANK	173..315	CDD:238125	74/141 (52%)
		ANK repeat	173..203	CDD:293786	12/29 (41%)
		Ank_2	177..261	CDD:289560	40/83 (48%)
		ANK repeat	230..261	CDD:293786	15/30 (50%)
		Ank_2	235..324	CDD:289560	47/88 (53%)
		ANK	258..414	CDD:238125	85/155 (55%)
		ANK repeat	299..329	CDD:293786	18/29 (62%)
		Ion_trans	501..665	CDD:278921	83/179 (46%)
osm-9	NP_500372.1	trp	49..789	CDD:273311	318/773 (41%)
		ANK repeat	171..202	CDD:293786	12/30 (40%)
		ANK repeat	227..258	CDD:293786	15/30 (50%)
		ANK repeat	260..294	CDD:293786	15/33 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166898
Domainoid	1	1.000	156	1.000	Domainoid score	I2574
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71049
Inparanoid	1	1.050	597	1.000	Inparanoid score	I522
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	1	1.000	-	-		oto18445
orthoMCL	1	0.900	-	-		OOG6_113402
Panther	1	1.100	-	-	LDO	PTHR10582
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17096
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790