Protein Alignment iav and trpv4

DIOPT Version :10

• Sequence 1: NP_572353.1
• Gene: iav / 31621
• FlyBaseID: FBgn0086693
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_002932129.1
• Gene: trpv4 / 100496204
• XenbaseID: XB-GENE-998899
• Length: 868
• Species: Xenopus tropicalis
• Alignment Length: 618
• Identity: 155/618 - (25%)
• Similarity: 266/618 - (43%)
• Gaps: 139/618 - (22%)

  Fly   155 LRVFPNLAL-DVMEGEEYLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANP 218
            ||.|.|... ||.    |.|.:|||::|.......|..|:|.|||:|.:|.|.||.|:|:
 Frog   219 LREFINSPFRDVY----YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDE----- 274

  Fly   219 AKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCG---SDPDAQDSFGNMILH----------- 269
                  .|..|.||.||:.|||.....:.:.|.:..   :|...|||.||.:||
 Frog   275 ------GGYFYFGELPLSLAACTNQPDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRE 333

  Fly   270 -----------MVVVCDKLDMFGYALRHPKTPAKNGIVNQTGLTPLTLACKLGRAEVFREMLELS 323
                       :|:.|.||        :|.: :...|.|...::||.:|.|||:..:|:.::.|.
 Frog   334 NTKFVTKVYDLLVIKCVKL--------YPDS-SLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLE 389

  Fly   324 ---------AREF--WRYSNITCSGYPLNALDTLLPDGRTNWNSALFIILNGTKPEHL-DMLDGG 376
                     :|:|  |.|..:..|.|.|:.|||...:     .|.|.|::..:|.|:. :||...
 Frog   390 IKDEEARHLSRKFRDWAYGPVYSSLYDLSMLDTCGEE-----VSVLEILVYNSKVENRHEMLAVE 449

  Fly   377 IIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQ 441
            .|..||.:||:.|....|...::.....::..::..|.||.
 Frog   450 PINELLRDKWQKFGAVSFYISVVSYLIAMIIFTLIAYYRPM------------------------ 490

  Fly   442 SDEGDSGGGDYNAQTVARY---CAEFATLV-GVLSYVIFQQGDEIKNQGLSAFLKQLSHAPAKAI 502
                 .|...|..:|...|   ..|..||: ||:.::     ..||:    .|:|:.....:..|
 Frog   491 -----DGTPPYPYRTTMDYMRLAGEIVTLLTGVVFFI-----TNIKD----LFMKKCPGVNSLFI 541

  Fly   503 --------FLFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYS 559
                    |::|.|:|:..:.: |:| .::..|:::||:...|...::|...::|||.:..|:..
 Frog   542 DGSFQLLYFIYSVLVIITAVLY-LVG-IESYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMLQK 604

  Fly   560 MITGDMFTFGIIYCIVLCGFSQAFYFLYK------------------GHPQVQSTMFNTYTSTWM 606
            ::..|:|.|.::|.:.:.|::.|...|..                  .:|..:.:  :|::...:
 Frog   605 ILFKDLFRFLLVYLLFMIGYASALVSLLNPCTSQESCIETSSNCTVPEYPSCRDS--STFSKFLL 667

  Fly   607 ALFQTTLGDYNYPDLNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQ 671
            .||:.|:|..:...:|...||.:...:.|.::|...:||||||||:||.|...|.::|::.|..|
 Frog   668 DLFKLTIGMGDLEMINSAKYPAVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKLQ 732

  Fly   672 WAKIVVTLERAVPQADAKGYLEAYSIPLGPSDD 704
            ||..::.:||:.|....|.:.....:.:|.:.|
 Frog   733 WATTILDIERSFPVCMRKAFRSGEMVTVGKNLD 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	TRPV	126..757	CDD:454755	155/618 (25%)
		ANK repeat	132..164	CDD:293786	4/9 (44%)
		ANK repeat	173..203	CDD:293786	12/29 (41%)
		ANK repeat	230..261	CDD:293786	9/33 (27%)
		ANK repeat	299..329	CDD:293786	10/40 (25%)
trpv4	XP_002932129.1	TRPV4	98..830	CDD:411979	155/618 (25%)
		ANK repeat	187..227	CDD:293786	4/7 (57%)
		ANK repeat	233..264	CDD:293786	12/30 (40%)
		ANK repeat	280..314	CDD:293786	9/33 (27%)