DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and trpv4

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_002932129.1	Gene:	trpv4 / 100496204	XenbaseID:	XB-GENE-998899	Length:	868	Species:	Xenopus tropicalis

Alignment Length:	618	Identity:	155/618 - (25%)
Similarity:	266/618 - (43%)	Gaps:	139/618 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 LRVFPNLAL-DVMEGEEYLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANP 218
            ||.|.|... ||.    |.|.:|||::|.......|..|:|.|||:|.:|.|.||.|:|:
Frog   219 LREFINSPFRDVY----YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDE----- 274

  Fly   219 AKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCG---SDPDAQDSFGNMILH----------- 269
                  .|..|.||.||:.|||.....:.:.|.:..   :|...|||.||.:||
Frog   275 ------GGYFYFGELPLSLAACTNQPDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRE 333

  Fly   270 -----------MVVVCDKLDMFGYALRHPKTPAKNGIVNQTGLTPLTLACKLGRAEVFREMLELS 323
                       :|:.|.||        :|.: :...|.|...::||.:|.|||:..:|:.::.|.
Frog   334 NTKFVTKVYDLLVIKCVKL--------YPDS-SLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLE 389

  Fly   324 ---------AREF--WRYSNITCSGYPLNALDTLLPDGRTNWNSALFIILNGTKPEHL-DMLDGG 376
                     :|:|  |.|..:..|.|.|:.|||...:     .|.|.|::..:|.|:. :||...
Frog   390 IKDEEARHLSRKFRDWAYGPVYSSLYDLSMLDTCGEE-----VSVLEILVYNSKVENRHEMLAVE 449

  Fly   377 IIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQ 441
            .|..||.:||:.|....|...::.....::..::..|.||.
Frog   450 PINELLRDKWQKFGAVSFYISVVSYLIAMIIFTLIAYYRPM------------------------ 490

  Fly   442 SDEGDSGGGDYNAQTVARY---CAEFATLV-GVLSYVIFQQGDEIKNQGLSAFLKQLSHAPAKAI 502
                 .|...|..:|...|   ..|..||: ||:.::     ..||:    .|:|:.....:..|
Frog   491 -----DGTPPYPYRTTMDYMRLAGEIVTLLTGVVFFI-----TNIKD----LFMKKCPGVNSLFI 541

  Fly   503 --------FLFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYS 559
                    |::|.|:|:..:.: |:| .::..|:::||:...|...::|...::|||.:..|:..
Frog   542 DGSFQLLYFIYSVLVIITAVLY-LVG-IESYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMLQK 604

  Fly   560 MITGDMFTFGIIYCIVLCGFSQAFYFLYK------------------GHPQVQSTMFNTYTSTWM 606
            ::..|:|.|.::|.:.:.|::.|...|..                  .:|..:.:  :|::...:
Frog   605 ILFKDLFRFLLVYLLFMIGYASALVSLLNPCTSQESCIETSSNCTVPEYPSCRDS--STFSKFLL 667

  Fly   607 ALFQTTLGDYNYPDLNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQ 671
            .||:.|:|..:...:|...||.:...:.|.::|...:||||||||:||.|...|.::|::.|..|
Frog   668 DLFKLTIGMGDLEMINSAKYPAVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKQIWKLQ 732

  Fly   672 WAKIVVTLERAVPQADAKGYLEAYSIPLGPSDD 704
            ||..::.:||:.|....|.:.....:.:|.:.|
Frog   733 WATTILDIERSFPVCMRKAFRSGEMVTVGKNLD 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	19/47 (40%)
		ANK repeat	132..164	CDD:293786	4/9 (44%)
		ANK	173..315	CDD:238125	49/166 (30%)
		ANK repeat	173..203	CDD:293786	12/29 (41%)
		Ank_2	177..261	CDD:289560	27/86 (31%)
		ANK repeat	230..261	CDD:293786	9/33 (27%)
		Ank_2	235..324	CDD:289560	28/122 (23%)
		ANK	258..414	CDD:238125	46/189 (24%)
		ANK repeat	299..329	CDD:293786	10/40 (25%)
		Ion_trans	501..665	CDD:278921	46/189 (24%)
trpv4	XP_002932129.1	TRPV4	98..830	CDD:411979	155/618 (25%)
		ANK repeat	187..227	CDD:293786	4/7 (57%)
		ANK repeat	233..264	CDD:293786	12/30 (40%)
		ANK repeat	280..314	CDD:293786	9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9325
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920