Protein Alignment iav and trpv4l.1

DIOPT Version :9

• Sequence 1: NP_572353.1
• Gene: iav / 31621
• FlyBaseID: FBgn0086693
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: XP_017950397.2
• Gene: trpv4l.1 / 100494662
• XenbaseID: XB-GENE-22066240
• Length: 1014
• Species: Xenopus tropicalis
• Alignment Length: 736
• Identity: 170/736 - (23%)
• Similarity: 299/736 - (40%)
• Gaps: 177/736 - (24%)

  Fly    71 GVFMYNDGKGQVINRAEFLRWKYRDH-TEVT--IPIEASLSIHDPLGKWEDHKACWQMQYRGALG 132
            |:.::.....:::..:.:.....||: ||||  .|.......:..:.|.::|  .:.:..||:..
 Frog   268 GIEIFQTKSCEMVMDSRYHNVTERDYGTEVTPYDPRRGPYPDYPDIKKLKEH--LFDIVSRGSAA 330

  Fly   133 E--------SLLHVL-------IICDSKVHTKLARVLLRV-------------FPNLALDVMEG- 168
            |        .|||..       .:.||...|.|::.|:.:             ...:.::|.:.
 Frog   331 ELEELRLLPFLLHEKKQLTDEEFLEDSTGKTCLSKALMHLNNGKNDTIPILIYIATITINVPQFI 395

  Fly   169 -----EEYLGASALHLSIAYSNNELVADLIEAGADIHQRAIGSFFLPRDQQRANPAKSTDYEGLA 228
                 :.|.|.:|||::|.....:.|..|::.|||:|.:|.|.||.|:|:           .|..
 Frog   396 NSPFLKYYDGQTALHIAIERRCKDYVELLVQNGADVHAQAKGRFFQPKDE-----------GGYF 449

  Fly   229 YMGEYPLAWAACC--------ANESVYNLLVDCGSDPDAQDSFGNMIL----------------- 268
            |.||.||:.|||.        ..|:|||     .:|...:||.||.:|
 Frog   450 YFGELPLSLAACTNQPDIVDYLTENVYN-----KADLCRRDSRGNTVLHALVAIADNTPENTKFV 509

  Fly   269 -----HMVVVCDKLDMFGYALRHPKTPAKNGIVNQTGLTPLTLACKLGRAEVFREMLELS----- 323
                 |:|:.|.||:         |..:...:.|...::||.:|.:||:.::|:.:::|.
 Frog   510 TEMYDHLVIKCAKLN---------KESSLETVTNNDKMSPLMMAAQLGKIDIFQHIIQLEIKDEE 565

  Fly   324 ----AREF--WRYSNITCSGYPLNALDTLLPDGRTNWNSAL-FIILNGTKPEHLDMLDGGIIQRL 381
                :|:|  |.|..:..|.|.|..||| ..||    :|.| .::...|.....:||....|..|
 Frog   566 ARHLSRKFRDWTYGPVYSSLYDLTTLDT-YEDG----DSVLEILVYKSTAKNRHEMLAVEPINEL 625

  Fly   382 LEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSEGSDASAAALLDIQSDEGD 446
            |:||||.|....|..........::..::..|.||.
 Frog   626 LKEKWKKFGAVLFYLSFFAYLFLMIIFTLVAYYRPM----------------------------- 661

  Fly   447 SGGGDYNAQTVA---RYCAEFATLVGVLSYVIFQQGDEI--KNQGL-SAFLK---QLSHAPAKAI 502
            .|...|..:|..   |...|...|:..:.:.|....|.|  |..|: |.|.:   ||.:
 Frog   662 EGTPPYPYRTTTDHLRLVGEIVILLVGIVFFIANIKDLIMKKYPGVYSLFTEGCFQLLN------ 720

  Fly   503 FLFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGDMFT 567
            |::|.|::|..|.:  :...:...|:::.|:...|...::|...::|||.:..|:..::..|:|.
 Frog   721 FIYSVLVLLTAILY--LAGIEAYLAVMVIALVLGWINALYFTRGLKLTGMYSVMLQKVLFKDLFR 783

  Fly   568 FGIIYCIVLCGFSQAFYFLYK------------------GHPQVQSTMFNTYTSTWMALFQTTLG 614
            |.::|.:.:.|::.|...|..                  .:|..|.:  .|::...:.||..|:|
 Frog   784 FLLVYLLFMVGYASALVSLLNPCTNEMICNDGQENCTVPENPSCQHS--TTFSRLLLNLFTLTIG 846

  Fly   615 DYNYPDLNQTTYPNLSKTVFVIFMIFVPILLLNMLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTL 679
            ..:...::...||.:...:.|.::|...:||||||||:||.|...|.::|::.|..|||..::.:
 Frog   847 MGDLEVISHAKYPAVFIILLVTYLIITFVLLLNMLIALMGETVGEVSKESKQIWQLQWATTILDI 911

  Fly   680 ERAVPQADAKGYLEAYSIPLG 700
            ||.:|....|.:....::.:|
 Frog   912 ERYLPAFMRKAFRSGEAVIIG 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	24/108 (22%)
		ANK repeat	132..164	CDD:293786	9/59 (15%)
		ANK	173..315	CDD:238125	48/171 (28%)
		ANK repeat	173..203	CDD:293786	11/29 (38%)
		Ank_2	177..261	CDD:289560	29/91 (32%)
		ANK repeat	230..261	CDD:293786	12/38 (32%)
		Ank_2	235..324	CDD:289560	28/127 (22%)
		ANK	258..414	CDD:238125	45/189 (24%)
		ANK repeat	299..329	CDD:293786	9/40 (23%)
		Ion_trans	501..665	CDD:278921	43/181 (24%)
trpv4l.1	XP_017950397.2	TRPV	281..968	CDD:424068	169/723 (23%)
		ANK repeat	359..402	CDD:293786	4/42 (10%)
		ANK repeat	404..435	CDD:293786	11/30 (37%)
		ANK repeat	451..485	CDD:293786	12/38 (32%)
		ANK repeat	487..526	CDD:293786	8/47 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9325
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010