DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment iav and trpv1

DIOPT Version :9

Sequence 1:	NP_572353.1	Gene:	iav / 31621	FlyBaseID:	FBgn0086693	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_031751641.1	Gene:	trpv1 / 100487208	XenbaseID:	XB-GENE-991320	Length:	858	Species:	Xenopus tropicalis

Alignment Length:	942	Identity:	220/942 - (23%)
Similarity:	357/942 - (37%)	Gaps:	284/942 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 MKPGAILDAVISQSSA----TACKCLLYKLADYKRGGDLIDAINSGGLIAVEQLIREQFGVFMYN 76
            ::.|.:.:.::.|||:    |:||...:||.|.:|   :.||...|....::.|:     |::
Frog    96 LEKGKLCNQLVRQSSSLESTTSCKDRTFKLYDQRR---IFDAAAYGDCDELDDLL-----VYL-- 150

  Fly    77 DGKGQVINRAEFLRWKYRDHTEVTIPIEASLSIHDPLGKWEDHKACWQMQYRGALGESLLHVLII 141
                            .|.|.::|         ::...:.|..|.|            ||..::.
Frog   151 ----------------LRTHKKLT---------NEEFKEKETGKTC------------LLKAMLN 178

  Fly   142 CDSKVHTKLARVL--------LRVFPNLALDVMEGEEYLGASALHLSIAYSNNELVADLIEAGAD 198
            .::.:::.:...|        ::.|.|.|   .....|.|.:|||::|...|.:||..|::.|||
Frog   179 LENGMNSTIPLFLEIAEKTDNIKEFINSA---YRDNYYRGQTALHIAIERRNMDLVELLLQHGAD 240

  Fly   199 IHQRAIGSFFLPRDQQRANPAKSTDYEGLAYMGEYPLAWAACCANESVYNLLVDCGSDP---DAQ 260
            :|.||.|.||          .|:....|. |.||.||:.|||....::...|:.....|   .|:
Frog   241 VHARADGEFF----------RKAKGKAGF-YFGELPLSLAACTNQTAMVQYLLQNQYSPANMAAK 294

  Fly   261 DSFGNMILHMVV---------------VCDKLDMFGYALRHPKTPAKNGIVNQTGLTPLTLACKL 310
            |:|||.:||.:|               :.:::.:.|..:| |....:. |:|:.|||||:||.|.
Frog   295 DTFGNTVLHALVDIADNTQENTTFVTKMYNEILVLGAQIR-PSLKLEE-IMNKKGLTPLSLAAKT 357

  Fly   311 GRAEVFREMLELSAREF-----------WRYSNITCSGYPLNALDTLLPDGRTNWNSALFIILNG 364
            |:..||..:|....:.|           |.|..:..|.|.|:.:||.      ..||.|.||...
Frog   358 GKIGVFAYILRREIKNFECRHLSRKFTEWAYGPVHSSLYDLSGVDTY------EKNSVLEIIAYS 416

  Fly   365 TK-PEHLDMLDGGIIQRLLEEKWKTFAQNQFLKRLLILSTHLLCLSVSVYLRPAHDGEAEDEDSE 428
            :: |...:||....:.:||::||..|.:..|....|...|:::..:|:.|.||.          :
Frog   417 SETPNRHEMLLVEPLNKLLQDKWDRFVKRIFYFNFLAYITYVIIFTVAAYYRPV----------D 471

  Fly   429 GSDASAAALLDIQSDEGDSGGGDYNAQTVARYCAEFATLVGVLSYVIFQQGDEIKNQGLSAF--- 490
            ||..     ..:|.:            :..|.|.|..|::|.: |..|        :|:..|
Frog   472 GSPP-----FPVQPN------------SYLRTCGELITVIGGI-YFFF--------RGIQYFTQR 510

  Fly   491 ---LKQL---SHAP----AKAIFLFSNLLILACIPFRLIGDTDTEEAILIFAVPGSWFLLMFFAG 545
               ||.|   |:..    |::|||..:.::..|       ..:...|.|:..:..||..::::..
Frog   511 RPSLKALIADSYYEFLFFAQSIFLLLSTILYFC-------GRNEYVAFLVICLAMSWANVLYYTR 568

  Fly   546 AIRLTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLY---KGHPQVQST----------- 596
            ..:|.|.:..||..:|..||..|..:|.:.|.||:.|...|.   :|...:.||
Frog   569 GFQLMGIYSVMIEKLILSDMVRFMFVYLLFLFGFAAALVTLIEDGEGRTDLNSTCGRRCCKPEPA 633

  Fly   597 MFNTYTSTWMALFQTTLG--------DYNYPDLNQTTYPNLSKTVFVI----FMIFVPILLLNML 649
            .:|....|...||:..:|        :|.|            |.||:.    ::|...|||||||
Frog   634 SYNNLYYTCQELFKFAIGMGDLEFTDNYKY------------KPVFIFLLITYVILTYILLLNML 686

  Fly   650 IAMMGNTYVTVIEQSEKEWMKQWAKI----VVTLE-----RAVPQAD-AKGYLEAY--SIPLGPS 702
            ||:||.|...|.::|:..|..|...:    ||.|.     ||:...| .|.:|.::  :...|.|
Frog   687 IALMGETVSKVAQESKSIWKLQEQDMDHMAVVPLNTSCLWRAITILDIEKSFLNSFRDTFRSGKS 751

  Fly   703 DDSGFEVRGVMVIKSKSKTRAKQRKGAVSNWKRVGRVTLTALKKRGMTGEEMRRLMWGRASISSP 767
            ...||...|      |...|...|...| ||.:                       |     :|.
Frog   752 VLVGFTPDG------KEDYRWCFRVDEV-NWNK-----------------------W-----NSN 781

  Fly   768 VKVTKQKLKDPYNLHTDSDFTNAMDMLTFASNP-----------ASSNGVTLRSVTAPPPAPPAP 821
            :.:.|:   ||.|.|      .....|:.:..|           .....|.:.:.|.|...|...
Frog   782 LGIIKE---DPGNCH------GLKSTLSASFRPRGKRWKSLVPHVKETNVKIDNETVPEEIPLQQ 837

  Fly   822 DPFRELIMMSDQRPETHDPHYFAGLQQLANKA 853
            .|     .::||.....|       |::.:||
Frog   838 KP-----TLADQTVPEED-------QEVTSKA 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
iav	NP_572353.1	ANKYR	<127..>202	CDD:223738	20/82 (24%)
		ANK repeat	132..164	CDD:293786	6/39 (15%)
		ANK	173..315	CDD:238125	52/159 (33%)
		ANK repeat	173..203	CDD:293786	13/29 (45%)
		Ank_2	177..261	CDD:289560	29/86 (34%)
		ANK repeat	230..261	CDD:293786	10/33 (30%)
		Ank_2	235..324	CDD:289560	31/106 (29%)
		ANK	258..414	CDD:238125	50/182 (27%)
		ANK repeat	299..329	CDD:293786	13/40 (33%)
		Ion_trans	501..665	CDD:278921	49/189 (26%)
trpv1	XP_031751641.1	TRPV1	122..786	CDD:411980	195/822 (24%)
		ANK repeat	168..210	CDD:293786	8/56 (14%)
		ANK repeat	214..245	CDD:293786	13/30 (43%)
		ANK repeat	261..295	CDD:293786	10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010