DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pod1 and CRN1

DIOPT Version :9

Sequence 1:	NP_001245554.1	Gene:	pod1 / 31620	FlyBaseID:	FBgn0029903	Length:	1266	Species:	Drosophila melanogaster
Sequence 2:	NP_013533.1	Gene:	CRN1 / 851148	SGDID:	S000004421	Length:	651	Species:	Saccharomyces cerevisiae

Alignment Length:	698	Identity:	183/698 - (26%)
Similarity:	317/698 - (45%)	Gaps:	107/698 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAWRF-KASKYKNAAPIVPKAEACVREICVGSYQTYGNNIAASGAFMAFNWEHT-GSSVAVLPLD 63
            |:.:| :||||::......|.|....::.|.:.....|.:..:|.|:|.||..: |.:.||:|::
Yeast     1 MSGKFVRASKYRHVFGQAAKKELQYEKLKVTNNAWDSNLLKTNGKFIAVNWNASGGGAFAVIPIE 65

  Fly    64 DCGRKSKTMPLLHGHTDTVTDLKFSPFHDGLLATASQDCLVKIWHIPE--KGLEQSLSDPEAI-- 124
            :.|:....:||..|||..|.|..|.||:|..:|:.|.|..:.||.|||  |..:....|.|.|
Yeast    66 EVGKAPDQVPLFRGHTAQVLDTDFDPFNDHRIASGSDDSKIGIWDIPENYKFHDHVDEDGEPIDI 130

  Fly   125 -----FSHKQRRVETVGFHPTADGLMYSTAAG-CVALFDLSTQKEIFSNNEHPEVIQSASWREDG 183
                 .:...|:|..|.:||.|:.::.|::.. .|.|:::.|.|::.: .:||:::.|.|:..||
Yeast   131 KPVKFLTGHARKVGHVLYHPVAENVLASSSGDYTVKLWNVETGKDMIT-LKHPDMVTSMSFSYDG 194

  Fly   184 SVLATSCKDKNVRIFDPRAAGSPIQLTAESHQSIKDSRVVWLGNQHRILTTGFDAARLRQVIIRD 248
            :.|||..:||.:|:::.|.  ..|.....:|...|:.|||||||..|:.||||.....||:.|.|
Yeast   195 NYLATVARDKKLRVWNIRE--EKIVSEGPAHTGAKNQRVVWLGNSDRLATTGFSKLSDRQIGIWD 257

  Fly   249 VRNFNTPEKTL----ELDCSTGILMPLFDPDTNMLFLAGKGDTTINYLEITDKDPYLIEGLRHTG 309
            .  ||..:..|    .:|.|:|||||.:|....:|:|.||||..|.|.|..:.:.:.:...:.|
Yeast   258 A--FNIEKGDLGGFYTVDQSSGILMPFYDEGNKILYLVGKGDGNIRYYEFQNDELFELSEFQST- 319

  Fly   310 EQTKGACLVPKRALKVMEAEVNRVLQ-LTSNMVIPIMYQVPRKTYRDFHADLYPETTGYKTELVA 373
            |..:|..:.|||.:.|.|.||.:..: :....:.|:.:.|||:: .:|..|:||:....|..|.|
Yeast   320 EAQRGFAVAPKRMVNVKENEVLKGFKTVVDQRIEPVSFFVPRRS-EEFQEDIYPDAPSNKPALTA 383

  Fly   374 GEWLNGSNQAVPKM------------SLDPAKR------------EHGDEPIIIHRGNLSDFVKN 414
            .||.:|.:...|.:            |...|||            |..::|.:  ...:|:..|.
Yeast   384 EEWFSGKSVEGPILVSMRSIYDGSAPSFHEAKRPQQPTTQETALEEKKEQPKV--EKPISESEKE 446

  Fly   415 LENQRAKSNTTGKPNQQAK------RNDNEHFVMLNTGNNFEE-KNGNDNSNESNGKKSTPSQSQ 472
            ::.:..||.:..|....:.      :.||....:|...::.:: .|..|.|.:::|.:....:..
Yeast   447 VKQEAPKSPSPLKSASSSSTINHVLKEDNSINKLLKKSSDIDQVNNAEDPSRDTSGWEEADDEPA 511

  Fly   473 P---DGECSELIRKFEAKYKVDSEKE---KAHAYAQSHEDDKESPTEHEHSTGSSEEVSSSGGLD 531
            |   :...:....|.:...||:..||   :..:.|...:.::..|.|.:    |||:..|
Yeast   512 PIKIETPVTPTETKKDRTPKVEPSKELKPEPVSIATDRKQEQSLPQEEK----SSEKTKS----- 567

  Fly   532 NHSASGSHSPPKPMPRTSRSNSLPEASDSAGESSSTNTPRPRPRTTAASAYKPRLGPKPFSSTTG 596
                          |...:| :.|.:|.:|.:::.|.:.:..|  :||......||.|.
Yeast   568 --------------PEQEKS-ATPPSSITAAKTAITASSKEEP--SAARTSPKSLGLKK------ 609

  Fly   597 DVSFDKVFAVPLAPGSHENISNVGQDSGVEMTPAQGAKPDLIVEIEIK 644
              |.:|:..:.|..          :|...::|.|...|.:.::::|.|
Yeast   610 --SVEKLSTLVLQL----------EDVVDKLTKANLDKDERLLKLEQK 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pod1	NP_001245554.1	DUF1899	6..62	CDD:286094	16/56 (29%)
		WD40	<75..237	CDD:295369	59/171 (35%)
		WD40 repeat	83..127	CDD:293791	17/52 (33%)
		WD40 repeat	132..166	CDD:293791	10/34 (29%)
		WD40 repeat	174..210	CDD:293791	12/35 (34%)
		WD40 repeat	217..260	CDD:293791	20/46 (43%)
		WD40 repeat	267..294	CDD:293791	13/26 (50%)
		WD40_4	341..384	CDD:292916	14/42 (33%)
		DUF1899	808..866	CDD:286094
		WD40	843..1116	CDD:295369
		WD40 repeat	884..923	CDD:293791
		WD40 repeat	937..973	CDD:293791
		WD40 repeat	979..1016	CDD:293791
		WD40 repeat	1024..1064	CDD:293791
		WD40 repeat	1071..1094	CDD:293791
		WD40_4	1146..1189	CDD:292916
CRN1	NP_013533.1	WD40	9..424	CDD:421866	132/421 (31%)
		WD40 repeat	85..138	CDD:293791	17/52 (33%)
		WD40 repeat	143..179	CDD:293791	10/36 (28%)
		WD40 repeat	186..221	CDD:293791	12/36 (33%)
		WD40 repeat	228..270	CDD:293791	19/43 (44%)
		WD40 repeat	278..315	CDD:293791	14/36 (39%)
		pilus_FilE	428..>600	CDD:411258	36/199 (18%)
		Chlamy_inclu_1	521..>641	CDD:411607	31/163 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I2320
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870