DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pod1 and CORO7

DIOPT Version :9

Sequence 1:	NP_001245554.1	Gene:	pod1 / 31620	FlyBaseID:	FBgn0029903	Length:	1266	Species:	Drosophila melanogaster
Sequence 2:	NP_078811.3	Gene:	CORO7 / 79585	HGNCID:	26161	Length:	925	Species:	Homo sapiens

Alignment Length:	1267	Identity:	384/1267 - (30%)
Similarity:	567/1267 - (44%)	Gaps:	351/1267 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RFKASKYKNAAPIVPKAEACVREICVGSYQTYGNNIAASGAFMAFNWEHTGSSVAVLPLDDCGRK 68
            ||:.||:::.....|:.|:.:.:|..|:..:..|:|.:|.:.:|||.:..| .:.::||...|..
Human     3 RFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPG-VLGIVPLQGQGED 66

  Fly    69 SKTMPLLHGHTDTVTDLKFSPFHDGLLATASQDCLVKIWHIPEKGLEQSL-SDPEAIFSHKQRRV 132
            .:.:..|..|:|.||||.||||.|.||||.|.|..||:|.:|..|  |:| |.|..:...:...|
Human    67 KRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPG--QALPSAPGVVLGPEDLPV 129

  Fly   133 ETVGFHPTADGLMYSTAAGCVALFDLSTQKEIFSNNEHPEVIQSASWREDGSVLATSCKDKNVRI 197
            |.:.||||:||::.|.|...|.::|.:.|:.:.....|.:::|||.|..||:::.|:||||.:||
Human   130 EVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRI 194

  Fly   198 FDPRAAGSPIQLTAESHQSIKDSRVVWLGNQHRILTTGFDAARLRQVIIRDVRNFNTPEKTLELD 262
            ||||......|.| ::|::.:|||:.|:|....:::|||:..|.|:|.:.|.|.|::...:|.||
Human   195 FDPRTKPRASQST-QAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLD 258

  Fly   263 CSTGILMPLFDPDTNMLFLAGKGDTTINYLEITDKDPYLIEGLRHTGEQT-KGACLVPKRALKVM 326
            .|.|.|:||.|||:.:|.|||||:..:...|:..:.|.|....:...|.. :||.|||::||.||
Human   259 TSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPVTQCVLESVLRGAALVPRQALAVM 323

  Fly   327 EAEVNRVLQLTSNMVIPIMYQVPRKTYRDFHADLYPETTGYKTELVAGEWLNGSNQAVPKMSLDP 391
            ..||.|||||:...::||.|.||||.. :||.||:|:|.|.........|..|.||.|.|:||:|
Human   324 SCEVLRVLQLSDTAIVPIGYHVPRKAV-EFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNP 387

  Fly   392 AKREHGDEPIIIHRGNLSDFVKNLENQRAKSNTTGKPNQQAKRNDNEHFVMLNTGNNFEEKNGND 456
            |.|.|
Human   388 ACRPH------------------------------------------------------------ 392

  Fly   457 NSNESNGKKSTPSQSQPDGECSELIRKFEAKYKVDSEKEKAHAYAQSHEDDKESPTEHEHSTGSS 521
                       ||.:      |.|:
Human   393 -----------PSFT------SCLV---------------------------------------- 400

  Fly   522 EEVSSSGGLDNHSASGSHSPPKPMPRTSRSNSLPEASDSAGESSSTNTPRPRPRTTAASAYKPRL 586
                              .|.:|:|.|::
Human   401 ------------------PPAEPLPDTAQ------------------------------------ 411

  Fly   587 GPKPFSSTTGDVSFDKVFAVPLAPGSHENISNVGQDSGVEMTPAQGAKPDLIVEIEIKKKHEREP 651
             |....:..||....:.|:.|
Human   412 -PAVMETPVGDADASEGFSSP-------------------------------------------- 431

  Fly   652 AVSGNGVQKSLTTSERRKSSADDDESSDKIFEQNSESSENSTEGEDRTDADLRRNCTSRSSFAER 716
                   ..|||:
Human   432 -------PSSLTS---------------------------------------------------- 437

  Fly   717 RRIYENRSKSQVDEKPQSPVPLRREHSKVEPLKPNQQQQQQGNVIDTKRISVPEGKLMEEHRRGN 781
                           |.:|..|
Human   438 ---------------PSTPSSL------------------------------------------- 444

  Fly   782 GAGLKKSATEAAFSAASTKRTSTVFGKVSKFRHLKGTPGHKSTHIENLRNLSRQIPGECNGFHAN 846
              |...|:|....::.|.:...::.|..|||||.:||..|:.:||.||:.|:...|||.:||.||
Human   445 --GPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCAN 507

  Fly   847 QERVAVPLSGPGGKIAIFELSRPGRLPDGVIPSLVNGSNIMDFQWDPFDAQRLAVACDDGIVKIW 911
            :.||||||...||::|:.||.:||||||..:|:|.||:.:.|..|||||..|||||.:|..:::|
Human   508 KLRVAVPLLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLW 572

  Fly   912 HIEAGGLSEPTNTPAGELTAHLDKIYFIRFHPLAADVLLTASYDMTIKLWDLRTMTEKCSLSGHT 976
            .:.|.||.|...||...||.|.:||..:|||||||:||.::|||:|:::|||:...::..|.||.
Human   573 RVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQ 637

  Fly   977 DQIFDFAWSPCGRLGATVCKDGKIRVYNPRKSETPIREGNGPVGTRGARITWALEGHYIVCTGFD 1041
            ||||..||||.|:..|||||||::|||.||....|::||.||.|.|||||.|..:|..::.:|||
Human   638 DQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFD 702

  Fly  1042 KVSERQISVYNAQKLS-APLNTASLDVSPSILIPFYDEDSSTLFVTGKGDSTIYCYEITDEEPYI 1105
            ..||||:.:|.|:.|: .||....|||:||.|:|.||.|:..:.:|||||:.::.||:..|.|:.
Human   703 SQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFF 767

  Fly  1106 CPLSHHRCTSLHQGLSFLTKNHCDVASVEFSKAYRLTNTTIEPLSFTVPRIKSELFQDDLFPPTR 1170
            ...:.......|:||..|.|..|||..||..:..||..:::||::|.:||::.|.||||:||.|.
Human   768 LECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTA 832

  Fly  1171 ITWSATLSSEDWFASNDKAAPKVSLKPEGMETLSSIQQVPAQ-PVKK-PDHPQFGGQKSEYEINK 1233
            :.|...||:|.|....:.....:||:|..|   |.:.|.|.: |.:: |...|:..:||:.:  |
Human   833 VIWEPVLSAEAWLQGANGQPWLLSLQPPDM---SPVSQAPREAPARRAPSSAQYLEEKSDQQ--K 892

  Fly  1234 QQEIQKSVSARM-EFTTKLEQDDMEGVDENEW 1264
            ::|:..::.|:: .....|.||..|||||:||
Human   893 KEELLNAMVAKLGNREDPLPQDSFEGVDEDEW 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pod1	NP_001245554.1	DUF1899	6..62	CDD:286094	13/55 (24%)
		WD40	<75..237	CDD:295369	68/162 (42%)
		WD40 repeat	83..127	CDD:293791	23/44 (52%)
		WD40 repeat	132..166	CDD:293791	13/33 (39%)
		WD40 repeat	174..210	CDD:293791	18/35 (51%)
		WD40 repeat	217..260	CDD:293791	14/42 (33%)
		WD40 repeat	267..294	CDD:293791	12/26 (46%)
		WD40_4	341..384	CDD:292916	18/42 (43%)
		DUF1899	808..866	CDD:286094	29/57 (51%)
		WD40	843..1116	CDD:295369	132/273 (48%)
		WD40 repeat	884..923	CDD:293791	17/38 (45%)
		WD40 repeat	937..973	CDD:293791	16/35 (46%)
		WD40 repeat	979..1016	CDD:293791	21/36 (58%)
		WD40 repeat	1024..1064	CDD:293791	17/40 (43%)
		WD40 repeat	1071..1094	CDD:293791	10/22 (45%)
		WD40_4	1146..1189	CDD:292916	18/42 (43%)
CORO7	NP_078811.3	WD40_4	6..428	CDD:330497	165/598 (28%)
		WD 1	75..115		23/41 (56%)
		WD40 repeat	81..124	CDD:293791	23/44 (52%)
		WD 2	124..163		13/38 (34%)
		WD40 repeat	129..165	CDD:293791	13/35 (37%)
		WD 3	166..205		18/38 (47%)
		WD40 repeat	172..208	CDD:293791	19/36 (53%)
		WD 4	209..253		15/43 (35%)
		WD40 repeat	215..256	CDD:293791	14/40 (35%)
		WD40 repeat	263..302	CDD:293791	15/38 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..461		14/204 (7%)
		WD40_4	471..880	CDD:330497	188/411 (46%)
		WD40 repeat	504..540	CDD:293791	20/35 (57%)
		WD 5	542..582		18/39 (46%)
		WD40 repeat	547..591	CDD:293791	19/43 (44%)
		WD 6	592..632		19/39 (49%)
		WD40 repeat	598..634	CDD:293791	16/35 (46%)
		WD 7	635..674		24/38 (63%)
		WD40 repeat	640..677	CDD:293791	21/36 (58%)
		WD 8	728..768		18/39 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	858..925		23/72 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158267
Domainoid	1	1.000	122	1.000	Domainoid score	I5668
eggNOG	1	0.900	-	-		E1_KOG1445
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11573
Inparanoid	1	1.050	697	1.000	Inparanoid score	I682
Isobase	1	0.950	-	0	Normalized mean entropy	S3185
OMA	1	1.010	-	-		QHG55469
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	1	1.000	-	-		FOG0004080
OrthoInspector	1	1.000	-	-		oto88542
orthoMCL	1	0.900	-	-		OOG6_105739
Panther	1	1.100	-	-	LDO	PTHR10856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3200
SonicParanoid	1	1.000	-	-		X4043
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750