DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pod1 and coro

DIOPT Version :9

Sequence 1:	NP_001245554.1	Gene:	pod1 / 31620	FlyBaseID:	FBgn0029903	Length:	1266	Species:	Drosophila melanogaster
Sequence 2:	NP_001260743.1	Gene:	coro / 35596	FlyBaseID:	FBgn0265935	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	175/584 - (29%)
Similarity:	287/584 - (49%)	Gaps:	73/584 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAWR-FKASKYKNAAPIVPKAEACVREICVGSYQTYGNNIAASGAFMAFNWEHT-GSSVAVLPLD 63
            |::| .::||:::......|.|.|...|.|..........|.:..|:|...|.. |.:..|||.:
  Fly     1 MSFRVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHN 65

  Fly    64 DCGRKSKTMPLLHGHTDTVTDLKFSPFHDGLLATASQDCLVKIWHIPEKGLEQSLSDPEAIFSHK 128
            ..||.:...||:.||...|.|:.:.|.:|.::|:.|:||:||:|.||:.||.::|::|.......
  Fly    66 KVGRIAADHPLVGGHKGPVLDIAWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFH 130

  Fly   129 QRRVETVGFHPTA-DGLMYSTAAGCVALFDLSTQKEIFSNNEHPEVIQSASWREDGSVLATSCKD 192
            ||||..|.:||:| :.|:.:.:...|.::::.|.:.:...:.||:::.||.:..|||.|.|:|||
  Fly   131 QRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKD 195

  Fly   193 KNVRIFDPRAAGSPIQLTAESHQSIKDSRVVWLGNQH-RILTTGFDAARLRQVIIRDVRNFNTPE 256
            |.:||:|||.|  .::..|..|:..|.:|.::|  :| .|.||||:.:..||..:|.....|.|.
  Fly   196 KKIRIYDPRTA--ELESEAMCHEGSKATRAIFL--RHGLIFTTGFNRSSERQYSLRAPDALNEPI 256

  Fly   257 KTLELDCSTGILMPLFDPDTNMLFLAGKGDTTINYLEITDKDPYLIEGLRH------TGEQTKGA 315
            ..:|||.|.|::.||:|.||||::|.||||:.|.|.|:|.:.|::     |      |.|..:|.
  Fly   257 VMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFV-----HYINTFQTTEPQRGI 316

  Fly   316 CLVPKRALKVMEAEVNRVLQLTSNMVIPIM-YQVPRKTYRD-FHADLYPETTGYKTELVAGEWLN 378
            .|:|||...|...||.:..::.:|.:..:: ..||||:  | |..||||:|......:.|.||::
  Fly   317 GLMPKRGCDVTTCEVAKFYRMNNNGLCQVISMTVPRKS--DLFQEDLYPDTLAEDAAITAEEWID 379

  Fly   379 GSNQAVPKMSLDPAKREHGDEPIIIHRGNLSDFV-KNLENQRAKSNTTGKPNQQAKRNDNEHFVM 442
            |.:       .||......|...|:..|.:|..| |:|..::| .|...||     |.|:.....
  Fly   380 GKD-------ADPITFSLKDRVSIVQGGYVSSSVNKSLPAKKA-GNILNKP-----RGDSASSGA 431

  Fly   443 LNT---GNNFEEKNGNDNSNESNGKKSTPSQSQPDGECSELIRKFEAKYKVDSEKEKAHAYAQSH 504
            .::   |.||  .:||:|.....|..:.....:......:.|||.:|   :..::|......::.
  Fly   432 TSSSAGGGNF--ASGNNNEASEGGPPAAVLSEKDLRTIQDEIRKLKA---IIVKQENRIRALEAK 491

  Fly   505 EDDKESPTEHEHSTGSSEEVSSSGGLDNHSASGSHSPPKPMPRTSRSNSLPEASDSAGESSSTN 568
            ||.:       :..||....:|:|.                     :.|..:||:||.:.:||:
  Fly   492 EDAR-------NKNGSDAAPASAGA---------------------ATSDGKASESANDHASTS 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pod1	NP_001245554.1	DUF1899	6..62	CDD:286094	14/56 (25%)
		WD40	<75..237	CDD:295369	59/163 (36%)
		WD40 repeat	83..127	CDD:293791	16/43 (37%)
		WD40 repeat	132..166	CDD:293791	8/34 (24%)
		WD40 repeat	174..210	CDD:293791	17/35 (49%)
		WD40 repeat	217..260	CDD:293791	14/43 (33%)
		WD40 repeat	267..294	CDD:293791	14/26 (54%)
		WD40_4	341..384	CDD:292916	15/44 (34%)
		DUF1899	808..866	CDD:286094
		WD40	843..1116	CDD:295369
		WD40 repeat	884..923	CDD:293791
		WD40 repeat	937..973	CDD:293791
		WD40 repeat	979..1016	CDD:293791
		WD40 repeat	1024..1064	CDD:293791
		WD40 repeat	1071..1094	CDD:293791
		WD40_4	1146..1189	CDD:292916
coro	NP_001260743.1	DUF1899	7..64	CDD:286094	14/56 (25%)
		WD40 repeat	37..78	CDD:293791	12/40 (30%)
		WD40	79..294	CDD:295369	84/218 (39%)
		WD40 repeat	85..129	CDD:293791	16/43 (37%)
		WD40 repeat	134..171	CDD:293791	8/36 (22%)
		WD40 repeat	178..213	CDD:293791	17/36 (47%)
		WD40 repeat	220..260	CDD:293791	13/41 (32%)
		WD40 repeat	267..308	CDD:293791	18/45 (40%)
		WD40_4	343..385	CDD:292916	15/50 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460698
Domainoid	1	1.000	68	1.000	Domainoid score	I2320
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10856
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950