DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pod1 and crn1

DIOPT Version :9

Sequence 1:	NP_001245554.1	Gene:	pod1 / 31620	FlyBaseID:	FBgn0029903	Length:	1266	Species:	Drosophila melanogaster
Sequence 2:	NP_593175.1	Gene:	crn1 / 2541961	PomBaseID:	SPAC23C4.02	Length:	601	Species:	Schizosaccharomyces pombe

Alignment Length:	667	Identity:	178/667 - (26%)
Similarity:	277/667 - (41%)	Gaps:	141/667 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAWRF-KASKYKNAAPIVPKAEACVREICVGSYQTYGNNIAASGAFMAFNWE-HTGSSVAVLPLD 63
            |:.|| :||||::......|.|.|...|.:.:.....|.::.:..:::.||. ..|.::||:||:
pombe     1 MSGRFVRASKYRHIFGQTCKKELCYDNIKLSNNAWDSNLLSVNPFYLSVNWNAGAGGALAVIPLN 65

  Fly    64 DCGRKSKTMPLLHGHTDTVTDLKFSPFHDGLLATASQDCLVKIWHIPEK-GLEQSLSD--PEAIF 125
            :.|:....:.|..|||..|.|..::||||.:||:...|..:.||.:||. .:.:...|  |.|..
pombe    66 ERGKLPDQVNLFRGHTAAVLDTDWNPFHDQVLASGGDDSKIMIWKVPEDYTVMEPYEDVHPIAEL 130

  Fly   126 SHKQRRVETVGFHPTADGLMYSTAA-GCVALFD-------LSTQKEIFSNNEHPEVIQSASWRED 182
            ....|:|..|.:||||..::.|::| ..:.|:|       :|.:.::        :.||.|:..|
pombe   131 KGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKGVAHVSLKMDV--------MCQSMSFNAD 187

  Fly   183 GSVLATSCKDKNVRIFDPRAAGSPIQLTAESHQSIKDSRVVWLGNQHRILTTGFDAARLRQVIIR 247
            |:.|.|:.:||.||::||| ...|:.: ...|...|:.||||||:..|..||||.....||:.:.
pombe   188 GTRLVTTSRDKKVRVWDPR-TDKPVSV-GNGHAGAKNPRVVWLGSLDRFATTGFSKMSDRQIALW 250

  Fly   248 DVRNFNTP-EKTLELDCSTGILMPLFDPDTNMLFLAGKGDTTINYLEITDKDPYLIEGLRHTGEQ 311
            |..|.:.| .....||..:|||||.:|..|.:::||||||..|.|.|..:...:.:...:....|
pombe   251 DPTNLSEPIGGFTTLDTGSGILMPFWDDGTKVIYLAGKGDGNIRYYEYENDVFHYLSEFKSVDPQ 315

  Fly   312 TKGACLVPKRALKVMEAEVNRVLQLTSNMVI-PIMYQVPRKTYRDFHADLYPETTGYKTELVAGE 375
             :|...:|||.:.|.|.||.|..:..::.:| ||.:.|||:: ..|.:|:||.....|..|.|.|
pombe   316 -RGIAFLPKRGVNVSENEVMRAYKSVNDSIIEPISFIVPRRS-ESFQSDIYPPAPSGKPSLTAEE 378

  Fly   376 WLNGSNQAVPKMSLDPAKREHGDEPIIIHRGNLSDFVKNLENQRAKSNTTGKPNQQAKRNDNEHF 440
            |.:|.:.                :|.::....|.:....:|  :|.|.|......|.::::.|
pombe   379 WASGKDA----------------QPDLLDMSTLYESKGTVE--KAVSATVPSAGAQVQKHNEE-- 423

  Fly   441 VMLNTGNNFEEKNGNDNSNESNGKKSTPS-QSQPDGECSELIRKFEAKYKVDSEKEKAHAYAQSH 504
                                   |..||. ::||                |...||.|.....|.
pombe   424 -----------------------KVETPKPEAQP----------------VSKPKESAEEQKPSK 449

  Fly   505 EDDKESPTEHEHSTGSSEEVSSSGGLDNHSASGSHSPPKPMPRTSRSNSLPEASDSAGESSSTNT 569
            |.:.:..|.   |....||.|.....|||....:.:.|| ..:|....|.|:
pombe   450 EPEVKPTTP---SASKVEEPSKKRDEDNHQKEETVTQPK-REKTPVEKSFPK------------- 497

  Fly   570 PRPRPRTTAASAYKPRLGPKPFSSTTGDVSFDKVFAVPLAPGSHENISNVGQDSGVEMTPAQGAK 634
            |...|.|.:....|     :|......:||.:...|.|||
pombe   498 PASSPVTFSEDVKK-----EPSEEKKLEVSDEAPKAAPLA------------------------- 532

  Fly   635 PDLIVEIEIKKKHEREP 651
                   |.||..|:||
pombe   533 -------ESKKVEEKEP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pod1	NP_001245554.1	DUF1899	6..62	CDD:286094	14/56 (25%)
		WD40	<75..237	CDD:295369	58/172 (34%)
		WD40 repeat	83..127	CDD:293791	15/46 (33%)
		WD40 repeat	132..166	CDD:293791	11/41 (27%)
		WD40 repeat	174..210	CDD:293791	15/35 (43%)
		WD40 repeat	217..260	CDD:293791	17/43 (40%)
		WD40 repeat	267..294	CDD:293791	14/26 (54%)
		WD40_4	341..384	CDD:292916	16/43 (37%)
		DUF1899	808..866	CDD:286094
		WD40	843..1116	CDD:295369
		WD40 repeat	884..923	CDD:293791
		WD40 repeat	937..973	CDD:293791
		WD40 repeat	979..1016	CDD:293791
		WD40 repeat	1024..1064	CDD:293791
		WD40 repeat	1071..1094	CDD:293791
		WD40_4	1146..1189	CDD:292916
crn1	NP_593175.1	DUF1899	7..64	CDD:286094	14/56 (25%)
		WD40	77..>324	CDD:295369	85/257 (33%)
		WD40 repeat	85..132	CDD:293791	15/46 (33%)
		WD40 repeat	137..172	CDD:293791	10/34 (29%)
		WD40 repeat	180..215	CDD:293791	15/36 (42%)
		WD40 repeat	222..263	CDD:293791	16/40 (40%)
		WD40 repeat	271..308	CDD:293791	15/36 (42%)
		WD40_4	345..387	CDD:292916	16/58 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870